Human Gene DNAAF10 (ENST00000295121.11_7) from GENCODE V47lift37
  Description: dynein axonemal assembly factor 10, transcript variant 1 (from RefSeq NM_138458.4)
Gencode Transcript: ENST00000295121.11_7
Gencode Gene: ENSG00000243667.7_12
Transcript (Including UTRs)
   Position: hg19 chr2:68,356,937-68,384,659 Size: 27,723 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr2:68,358,370-68,384,575 Size: 26,206 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:68,356,937-68,384,659)mRNA (may differ from genome)Protein (357 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: WDR92_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 92; AltName: Full=WD repeat-containing protein Monad;
FUNCTION: Seems to act as a modulator of apoptosis.
TISSUE SPECIFICITY: Widely expressed with the highest expression in testis.
SIMILARITY: Contains 6 WD repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.57 RPKM in Spleen
Total median expression: 15.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.8084-0.319 Picture PostScript Text
3' UTR -431.201433-0.301 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3I2N - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96MX6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043130 ubiquitin binding

Biological Process:
GO:0006915 apoptotic process


-  Descriptions from all associated GenBank mRNAs
  AY183476 - Homo sapiens HZGJ (HZGJ) mRNA, complete cds.
AK058090 - Homo sapiens cDNA FLJ25361 fis, clone TST01713.
AK090527 - Homo sapiens cDNA FLJ33208 fis, clone ADRGL2008023.
AK056303 - Homo sapiens cDNA FLJ31741 fis, clone NT2RI2007148.
JD104774 - Sequence 85798 from Patent EP1572962.
JD517162 - Sequence 498186 from Patent EP1572962.
JD461265 - Sequence 442289 from Patent EP1572962.
JD537880 - Sequence 518904 from Patent EP1572962.
JD558949 - Sequence 539973 from Patent EP1572962.
JD135670 - Sequence 116694 from Patent EP1572962.
JD135669 - Sequence 116693 from Patent EP1572962.
JD181004 - Sequence 162028 from Patent EP1572962.
JD051335 - Sequence 32359 from Patent EP1572962.
JD217445 - Sequence 198469 from Patent EP1572962.
JD408504 - Sequence 389528 from Patent EP1572962.
JD195722 - Sequence 176746 from Patent EP1572962.
JD194614 - Sequence 175638 from Patent EP1572962.
JD542175 - Sequence 523199 from Patent EP1572962.
JD194613 - Sequence 175637 from Patent EP1572962.
JD144607 - Sequence 125631 from Patent EP1572962.
JD429612 - Sequence 410636 from Patent EP1572962.
JD275714 - Sequence 256738 from Patent EP1572962.
JD158877 - Sequence 139901 from Patent EP1572962.
JD076565 - Sequence 57589 from Patent EP1572962.
JD421701 - Sequence 402725 from Patent EP1572962.
JD432565 - Sequence 413589 from Patent EP1572962.
JD102091 - Sequence 83115 from Patent EP1572962.
JD119079 - Sequence 100103 from Patent EP1572962.
JD107682 - Sequence 88706 from Patent EP1572962.
JD046811 - Sequence 27835 from Patent EP1572962.
JD263104 - Sequence 244128 from Patent EP1572962.
JD485246 - Sequence 466270 from Patent EP1572962.
JD069678 - Sequence 50702 from Patent EP1572962.
AL834142 - Homo sapiens mRNA; cDNA DKFZp434B156 (from clone DKFZp434B156).
BC066657 - Homo sapiens WD repeat domain 92, mRNA (cDNA clone MGC:70422 IMAGE:6164689), complete cds.
BC020271 - Homo sapiens WD repeat domain 92, mRNA (cDNA clone IMAGE:4128840).
JD517575 - Sequence 498599 from Patent EP1572962.
JD366429 - Sequence 347453 from Patent EP1572962.
JD155864 - Sequence 136888 from Patent EP1572962.
JD517574 - Sequence 498598 from Patent EP1572962.
JD155865 - Sequence 136889 from Patent EP1572962.
JD105892 - Sequence 86916 from Patent EP1572962.
AY541587 - Homo sapiens unknown mRNA.
JD076596 - Sequence 57620 from Patent EP1572962.
JD180038 - Sequence 161062 from Patent EP1572962.
JD293986 - Sequence 275010 from Patent EP1572962.
HM005607 - Homo sapiens clone HTL-S-67 testicular secretory protein Li 67 mRNA, complete cds.
EU832799 - Synthetic construct Homo sapiens clone HAIB:100067828; DKFZo008D0633 WD repeat domain 92 protein (WDR92) gene, encodes complete protein.
GQ129363 - Synthetic construct Homo sapiens clone HAIB:100068488; DKFZo004D0634 WD repeat domain 92 protein (WDR92) gene, partial cds.
BC036904 - Homo sapiens monad, mRNA (cDNA clone IMAGE:4525667).
BC014022 - Homo sapiens WD repeat domain 92, mRNA (cDNA clone MGC:20583 IMAGE:4309224), complete cds.
KJ903664 - Synthetic construct Homo sapiens clone ccsbBroadEn_13058 WDR92 gene, encodes complete protein.
EU831464 - Synthetic construct Homo sapiens clone HAIB:100066493; DKFZo008F0617 WD repeat domain 92 protein (WDR92) gene, encodes complete protein.
EU831551 - Synthetic construct Homo sapiens clone HAIB:100066580; DKFZo004F0618 WD repeat domain 92 protein (WDR92) gene, encodes complete protein.
CU680746 - Synthetic construct Homo sapiens gateway clone IMAGE:100022403 5' read WDR92 mRNA.
JD021060 - Sequence 2084 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DAA10_HUMAN, DNAAF10 , ENST00000295121.1, ENST00000295121.10, ENST00000295121.2, ENST00000295121.3, ENST00000295121.4, ENST00000295121.5, ENST00000295121.6, ENST00000295121.7, ENST00000295121.8, ENST00000295121.9, NM_138458, Q96CR6, Q96MX6, uc317ljz.1, uc317ljz.2, WDR92
UCSC ID: ENST00000295121.11_7
RefSeq Accession: NM_138458.4
Protein: Q96MX6 (aka WDR92_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.