ID:WRIP1_HUMAN DESCRIPTION: RecName: Full=ATPase WRNIP1; AltName: Full=Werner helicase-interacting protein 1; FUNCTION: Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis. SUBUNIT: Homooligomer; most likely an octamer. Interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN. Interacts (via UBZ-type zinc finger) with polyubiquitin. INTERACTION: O95786:DDX58; NbExp=2; IntAct=EBI-2513471, EBI-995350; Q9H0E2:TOLLIP; NbExp=2; IntAct=EBI-2513471, EBI-74615; SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Colocalizes with WRN in granular structures in the nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Sumoylated with SUMO1 and SUMO2/3. SIMILARITY: Belongs to the AAA ATPase family. SIMILARITY: Contains 1 UBZ-type zinc finger. SEQUENCE CAUTION: Sequence=AAF80563.1; Type=Erroneous initiation; Sequence=BAB15383.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96S55
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000731 DNA synthesis involved in DNA repair GO:0002376 immune system process GO:0006260 DNA replication GO:0006281 DNA repair GO:0006974 cellular response to DNA damage stimulus GO:0030174 regulation of DNA-dependent DNA replication initiation GO:0045087 innate immune response
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
