ID:XPA_HUMAN DESCRIPTION: RecName: Full=DNA repair protein complementing XP-A cells; AltName: Full=Xeroderma pigmentosum group A-complementing protein; FUNCTION: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. SUBUNIT: Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. INTERACTION: P15927:RPA2; NbExp=3; IntAct=EBI-295222, EBI-621404; Q96EB6:SIRT1; NbExp=8; IntAct=EBI-295222, EBI-1802965; Q9HCS7:XAB2; NbExp=2; IntAct=EBI-295222, EBI-295232; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in various cell lines and in skin fibroblasts. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Ubiquitinated by HERC2 leading to degradation by the proteasome. DISEASE: Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders. SIMILARITY: Belongs to the XPA family. WEB RESOURCE: Name=Allelic variations of the XP genes; URL="http://www.xpmutations.org/"; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/XPAID104.html"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/XPA"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/xpa/"; WEB RESOURCE: Name=Protein Spotlight; Note=Nature's flaws - Issue 142 of September 2012; URL="http://www.expasy.org/spotlight/back_issues/sptlt142.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23025
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC014965 - Homo sapiens xeroderma pigmentosum, complementation group A, mRNA (cDNA clone MGC:23059 IMAGE:4878739), complete cds. LF383868 - JP 2014500723-A/191371: Polycomb-Associated Non-Coding RNAs. D14533 - Homo sapiens mRNA for XPAC protein, complete cds. JD182865 - Sequence 163889 from Patent EP1572962. JD148960 - Sequence 129984 from Patent EP1572962. JD279222 - Sequence 260246 from Patent EP1572962. JD145685 - Sequence 126709 from Patent EP1572962. JD450745 - Sequence 431769 from Patent EP1572962. JD170678 - Sequence 151702 from Patent EP1572962. KJ892389 - Synthetic construct Homo sapiens clone ccsbBroadEn_01783 XPA gene, encodes complete protein. BT019518 - Homo sapiens xeroderma pigmentosum, complementation group A mRNA, complete cds. DQ893624 - Synthetic construct clone IMAGE:100006254; FLH184267.01X; RZPDo839D12144D xeroderma pigmentosum, complementation group A (XPA) gene, encodes complete protein. DQ895423 - Synthetic construct Homo sapiens clone IMAGE:100009883; FLH184263.01L; RZPDo839D12143D xeroderma pigmentosum, complementation group A (XPA) gene, encodes complete protein. AB590398 - Synthetic construct DNA, clone: pFN21AE1316, Homo sapiens XPA gene for xeroderma pigmentosum, complementation group A, without stop codon, in Flexi system. LF354565 - JP 2014500723-A/162068: Polycomb-Associated Non-Coding RNAs. KC899693 - Homo sapiens mutant xeroderma pigmentosum complementation group A (XPA) mRNA, partial cds. LF354568 - JP 2014500723-A/162071: Polycomb-Associated Non-Coding RNAs. LF354569 - JP 2014500723-A/162072: Polycomb-Associated Non-Coding RNAs. S89853 - XPAC=XP group A complementing {exon 3, zinc finger motif} [human, mRNA Partial Mutant, 45 nt]. LF354570 - JP 2014500723-A/162073: Polycomb-Associated Non-Coding RNAs. JD444585 - Sequence 425609 from Patent EP1572962. MA619445 - JP 2018138019-A/191371: Polycomb-Associated Non-Coding RNAs. MA590142 - JP 2018138019-A/162068: Polycomb-Associated Non-Coding RNAs. MA590145 - JP 2018138019-A/162071: Polycomb-Associated Non-Coding RNAs. MA590146 - JP 2018138019-A/162072: Polycomb-Associated Non-Coding RNAs. MA590147 - JP 2018138019-A/162073: Polycomb-Associated Non-Coding RNAs. MB032888 - JP 2019097423-A/1: Antisense oligonucleotide inducing XPA exon3 skipping. MB032889 - JP 2019097423-A/2: Antisense oligonucleotide inducing XPA exon3 skipping. MB032892 - JP 2019097423-A/5: Antisense oligonucleotide inducing XPA exon3 skipping. MB032890 - JP 2019097423-A/3: Antisense oligonucleotide inducing XPA exon3 skipping. MB032894 - JP 2019097423-A/7: Antisense oligonucleotide inducing XPA exon3 skipping.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P23025 (Reactome details) participates in the following event(s):
R-HSA-5689861 Recruitment of XPA and release of CAK R-HSA-6782004 Assembly of the pre-incision complex in TC-NER R-HSA-5690988 3'-incision of DNA by ERCC5 (XPG) in GG-NER R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER R-HSA-5696670 CHD1L is recruited to GG-NER site R-HSA-5690213 DNA polymerases delta, epsilon or kappa bind the GG-NER site R-HSA-6790454 SUMOylation of XPC R-HSA-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA R-HSA-5690990 5'- incision of DNA by ERCC1:ERCC4 in GG-NER R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6 R-HSA-6782131 RNA Pol II backtracking in TC-NER R-HSA-6782138 ERCC5 and RPA bind TC-NER site R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER R-HSA-6790487 RNF111 ubiquitinates SUMOylated XPC R-HSA-5689317 Formation of the pre-incision complex in GG-NER R-HSA-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER R-HSA-5690991 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER R-HSA-5696395 Formation of Incision Complex in GG-NER R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-5696400 Dual Incision in GG-NER R-HSA-6782135 Dual incision in TC-NER R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-5696398 Nucleotide Excision Repair R-HSA-73894 DNA Repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
