ID:XRCC1_HUMAN DESCRIPTION: RecName: Full=DNA repair protein XRCC1; AltName: Full=X-ray repair cross-complementing protein 1; FUNCTION: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. SUBUNIT: Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. INTERACTION: Q8IW19:APLF; NbExp=7; IntAct=EBI-947466, EBI-1256044; Q7Z2E3:APTX; NbExp=8; IntAct=EBI-947466, EBI-847814; SUBCELLULAR LOCATION: Nucleus. Note=Accumulates at sites of DNA damage. PTM: Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF. PTM: Sumoylated. POLYMORPHISM: Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage. SIMILARITY: Contains 2 BRCT domains. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/xrcc1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18887
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003684 damaged DNA binding GO:0003909 DNA ligase activity GO:0005515 protein binding GO:0019899 enzyme binding GO:0032356 oxidized DNA binding GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity
Biological Process: GO:0000012 single strand break repair GO:0000724 double-strand break repair via homologous recombination GO:0001666 response to hypoxia GO:0006281 DNA repair GO:0006283 transcription-coupled nucleotide-excision repair GO:0006284 base-excision repair GO:0006288 base-excision repair, DNA ligation GO:0006297 nucleotide-excision repair, DNA gap filling GO:0006303 double-strand break repair via nonhomologous end joining GO:0006974 cellular response to DNA damage stimulus GO:0010033 response to organic substance GO:0010836 negative regulation of protein ADP-ribosylation GO:0021587 cerebellum morphogenesis GO:0021766 hippocampus development GO:0033194 response to hydroperoxide GO:0042493 response to drug GO:0050882 voluntary musculoskeletal movement GO:0061819 telomeric DNA-containing double minutes formation GO:1903518 positive regulation of single strand break repair GO:1904877 positive regulation of DNA ligase activity GO:1905765 negative regulation of protection from non-homologous end joining at telomere GO:1990414 replication-born double-strand break repair via sister chromatid exchange
M36089 - Human DNA-repair protein (XRCC1) mRNA, complete cds. BC023593 - Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1, mRNA (cDNA clone MGC:23349 IMAGE:4646806), complete cds. AB208781 - Homo sapiens mRNA for X-ray repair cross complementing protein 1 variant protein. AK300163 - Homo sapiens cDNA FLJ50209 complete cds, highly similar to DNA-repair protein XRCC1. LF384227 - JP 2014500723-A/191730: Polycomb-Associated Non-Coding RNAs. AK315332 - Homo sapiens cDNA, FLJ96373, highly similar to Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA. AB384718 - Synthetic construct DNA, clone: pF1KB3003, Homo sapiens XRCC1 gene for DNA-repair protein XRCC1, complete cds, without stop codon, in Flexi system. CR456728 - Homo sapiens full open reading frame cDNA clone RZPDo834H1014D for gene XRCC1, X-ray repair complementing defective repair in Chinese hamster cells 1; complete cds, incl. stopcodon. LF367056 - JP 2014500723-A/174559: Polycomb-Associated Non-Coding RNAs. LF367055 - JP 2014500723-A/174558: Polycomb-Associated Non-Coding RNAs. LF367054 - JP 2014500723-A/174557: Polycomb-Associated Non-Coding RNAs. AK293542 - Homo sapiens cDNA FLJ56491 complete cds, highly similar to DNA-repair protein XRCC1. LF367053 - JP 2014500723-A/174556: Polycomb-Associated Non-Coding RNAs. LF367052 - JP 2014500723-A/174555: Polycomb-Associated Non-Coding RNAs. LF367051 - JP 2014500723-A/174554: Polycomb-Associated Non-Coding RNAs. MA619804 - JP 2018138019-A/191730: Polycomb-Associated Non-Coding RNAs. MA602633 - JP 2018138019-A/174559: Polycomb-Associated Non-Coding RNAs. MA602632 - JP 2018138019-A/174558: Polycomb-Associated Non-Coding RNAs. MA602631 - JP 2018138019-A/174557: Polycomb-Associated Non-Coding RNAs. MA602630 - JP 2018138019-A/174556: Polycomb-Associated Non-Coding RNAs. MA602629 - JP 2018138019-A/174555: Polycomb-Associated Non-Coding RNAs. MA602628 - JP 2018138019-A/174554: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P18887 (Reactome details) participates in the following event(s):
R-HSA-110376 Recruitment of LIG3:XRCC1 complex to the site of repair by POLB R-HSA-5649726 LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA R-HSA-5687673 MRN recruits LIG3:XRCC1 to MMEJ sites R-HSA-110380 Dissociation of LIG3:XRCC1 complex from the BER site R-HSA-5649724 LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site R-HSA-5687675 LIG3 ligates remaining SSBs in MMEJ R-HSA-73932 Resynthesis of excised residue by POLB R-HSA-73931 LIG3-mediated DNA ligation via the single-nucleotide replacement pathway R-HSA-5649734 LIG3 ligates NEIL1,NEIL2-generated single strand break R-HSA-5649705 PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) R-HSA-5649723 POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution R-HSA-5690997 Ligation of newly synthesized repair patch to incised DNA in GG-NER R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5685939 HDR through MMEJ (alt-NHEJ) R-HSA-73933 Resolution of Abasic Sites (AP sites) R-HSA-5693538 Homology Directed Repair R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-73884 Base Excision Repair R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-73894 DNA Repair R-HSA-5696398 Nucleotide Excision Repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
