Human Gene YAE1 (ENST00000223273.7_6) from GENCODE V47lift37
  Description: YAE1 maturation factor of ABCE1, transcript variant 1 (from RefSeq NM_020192.5)
Gencode Transcript: ENST00000223273.7_6
Gencode Gene: ENSG00000241127.8_11
Transcript (Including UTRs)
   Position: hg19 chr7:39,606,003-39,612,480 Size: 6,478 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr7:39,606,018-39,612,305 Size: 6,288 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersGene AllelesRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:39,606,003-39,612,480)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.05 RPKM in Testis
Total median expression: 215.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -18.60175-0.106 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019191 - Essential_protein_Yae1_N

Pfam Domains:
PF09811 - Essential protein Yae1, N terminal

ModBase Predicted Comparative 3D Structure on Q9NRH1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006413 translational initiation
GO:0042273 ribosomal large subunit biogenesis


-  Descriptions from all associated GenBank mRNAs
  LP896449 - Sequence 1313 from Patent EP3253886.
AK314937 - Homo sapiens cDNA, FLJ95848.
AK293511 - Homo sapiens cDNA FLJ57706 complete cds.
BC022043 - Homo sapiens chromosome 7 open reading frame 36, mRNA (cDNA clone MGC:27139 IMAGE:4734433), complete cds.
AF226046 - Homo sapiens GK003 (GK003) mRNA, complete cds.
DQ896074 - Synthetic construct Homo sapiens clone IMAGE:100010534; FLH263677.01L; RZPDo839E0565D chromosome 7 open reading frame 36 (C7orf36) gene, encodes complete protein.
DQ896075 - Synthetic construct Homo sapiens clone IMAGE:100010535; FLH190089.01L; RZPDo839E0665D chromosome 7 open reading frame 36 (C7orf36) gene, encodes complete protein.
DQ892829 - Synthetic construct clone IMAGE:100005459; FLH190093.01X; RZPDo839E0675D chromosome 7 open reading frame 36 (C7orf36) gene, encodes complete protein.
KJ899288 - Synthetic construct Homo sapiens clone ccsbBroadEn_08682 YAE1D1 gene, encodes complete protein.
CR457198 - Homo sapiens full open reading frame cDNA clone RZPDo834F068D for gene C7orf36, chromosome 7 open reading frame 36; complete cds, incl. stopcodon.
BX648555 - Homo sapiens mRNA; cDNA DKFZp779B0135 (from clone DKFZp779B0135).
JD245657 - Sequence 226681 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D1W4, B4DE83, C7orf36, ENST00000223273.1, ENST00000223273.2, ENST00000223273.3, ENST00000223273.4, ENST00000223273.5, ENST00000223273.6, GK003, NM_020192, Q6IAF7, Q8WVZ5, Q9NRH1, uc317dha.1, uc317dha.2, YAE1 , YAE1D1 , YAE1_HUMAN
UCSC ID: ENST00000223273.7_6
RefSeq Accession: NM_020192.5
Protein: Q9NRH1 (aka YAED1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.