Human Gene YLPM1 (ENST00000325680.12_6) from GENCODE V47lift37

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Description: YLP motif containing 1 (from RefSeq NM_019589.3)
Gencode Transcript: ENST00000325680.12_6
Gencode Gene: ENSG00000119596.18_15
Transcript (Including UTRs)
Position: hg19 chr14:75,230,019-75,304,021 Size: 74,003 Total Exon Count: 21 Strand: +
Coding Region
Position: hg19 chr14:75,230,193-75,302,114 Size: 71,922 Coding Exon Count: 20

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:75,230,019-75,304,021)			mRNA (may differ from genome)		Protein (2146 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: YLPM1_HUMAN DESCRIPTION: RecName: Full=YLP motif-containing protein 1; AltName: Full=Nuclear protein ZAP3; AltName: Full=ZAP113; FUNCTION: Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation (By similarity). SUBUNIT: Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA (By similarity). INTERACTION: O00555:CACNA1A; NbExp=2; IntAct=EBI-712871, EBI-766279; SUBCELLULAR LOCATION: Nucleus. Nucleus speckle (By similarity). Note=Migrates to nucleolar caps upon blockage of transcription. TISSUE SPECIFICITY: Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level). SEQUENCE CAUTION: Sequence=AAC42008.1; Type=Frameshift; Positions=1723; Sequence=AAF61275.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: YLPM1 Diseases sorted by gene-association score: early-onset familial alzheimer disease (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene D002794 Choline D016572 Cyclosporine D005492 Folic Acid D008715 Methionine D010634 Phenobarbital D011285 Pregnenolone Carbonitrile D012643 Selenium D013749 Tetrachlorodibenzodioxin D014810 Vitamin E C006632 arsenic trioxide C018021 cobaltous chloride C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 17.71 RPKM in Testis Total median expression: 466.90 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-84.10	174	-0.483	Picture	PostScript	Text
3' UTR	-378.80	1580	-0.240	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026314 - YLP_motif_con_p1

Pfam Domains:
PF13671 - AAA domain

SCOP Domains:
46966 - Spectrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on P49750


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0005515 protein binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0008150 biological_process Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005829 cytosol GO:0016607 nuclear speck

Descriptions from all associated GenBank mRNAs


	LF209600 - JP 2014500723-A/17103: Polycomb-Associated Non-Coding RNAs. AK095760 - Homo sapiens cDNA FLJ38441 fis, clone FEBRA2017441, moderately similar to Mus musculus mRNA for nuclear protein ZAP. BC172585 - Synthetic construct Homo sapiens clone IMAGE:100069279, MGC:199290 YLP motif containing 1 (YLPM1) mRNA, encodes complete protein. BC044636 - Homo sapiens YLP motif containing 1, mRNA (cDNA clone IMAGE:3622526), partial cds. MA445177 - JP 2018138019-A/17103: Polycomb-Associated Non-Coding RNAs. LF329996 - JP 2014500723-A/137499: Polycomb-Associated Non-Coding RNAs. LF329997 - JP 2014500723-A/137500: Polycomb-Associated Non-Coding RNAs. LF330000 - JP 2014500723-A/137503: Polycomb-Associated Non-Coding RNAs. LF330002 - JP 2014500723-A/137505: Polycomb-Associated Non-Coding RNAs. LF330005 - JP 2014500723-A/137508: Polycomb-Associated Non-Coding RNAs. MA565573 - JP 2018138019-A/137499: Polycomb-Associated Non-Coding RNAs. MA565574 - JP 2018138019-A/137500: Polycomb-Associated Non-Coding RNAs. MA565577 - JP 2018138019-A/137503: Polycomb-Associated Non-Coding RNAs. MA565579 - JP 2018138019-A/137505: Polycomb-Associated Non-Coding RNAs. MA565582 - JP 2018138019-A/137508: Polycomb-Associated Non-Coding RNAs. AK090435 - Homo sapiens mRNA for FLJ00353 protein. LF330011 - JP 2014500723-A/137514: Polycomb-Associated Non-Coding RNAs. AK091050 - Homo sapiens cDNA FLJ33731 fis, clone BRAWH2017685. AX746751 - Sequence 276 from Patent EP1308459. AL832365 - Homo sapiens mRNA; cDNA DKFZp451P176 (from clone DKFZp451P176). LF330012 - JP 2014500723-A/137515: Polycomb-Associated Non-Coding RNAs. LF330013 - JP 2014500723-A/137516: Polycomb-Associated Non-Coding RNAs. LF330015 - JP 2014500723-A/137518: Polycomb-Associated Non-Coding RNAs. LF330017 - JP 2014500723-A/137520: Polycomb-Associated Non-Coding RNAs. JD290745 - Sequence 271769 from Patent EP1572962. L40400 - Homo sapiens (clone zap113) mRNA, 3' end of cds. LF330028 - JP 2014500723-A/137531: Polycomb-Associated Non-Coding RNAs. LF330029 - JP 2014500723-A/137532: Polycomb-Associated Non-Coding RNAs. LF330030 - JP 2014500723-A/137533: Polycomb-Associated Non-Coding RNAs. LF330031 - JP 2014500723-A/137534: Polycomb-Associated Non-Coding RNAs. LF330032 - JP 2014500723-A/137535: Polycomb-Associated Non-Coding RNAs. LF330033 - JP 2014500723-A/137536: Polycomb-Associated Non-Coding RNAs. LF330034 - JP 2014500723-A/137537: Polycomb-Associated Non-Coding RNAs. LF330035 - JP 2014500723-A/137538: Polycomb-Associated Non-Coding RNAs. LF330036 - JP 2014500723-A/137539: Polycomb-Associated Non-Coding RNAs. AK297582 - Homo sapiens cDNA FLJ58590 complete cds, highly similar to YLP motif-containing protein 1. LF330037 - JP 2014500723-A/137540: Polycomb-Associated Non-Coding RNAs. LF330040 - JP 2014500723-A/137543: Polycomb-Associated Non-Coding RNAs. LF330042 - JP 2014500723-A/137545: Polycomb-Associated Non-Coding RNAs. L40403 - Homo sapiens (clone zap3) mRNA, 3' end of cds. LF330044 - JP 2014500723-A/137547: Polycomb-Associated Non-Coding RNAs. LF330045 - JP 2014500723-A/137548: Polycomb-Associated Non-Coding RNAs. JD019630 - Sequence 654 from Patent EP1572962. JD030900 - Sequence 11924 from Patent EP1572962. BC007792 - Homo sapiens YLP motif containing 1, mRNA (cDNA clone IMAGE:4026352), partial cds. BC023570 - Homo sapiens YLP motif containing 1, mRNA (cDNA clone IMAGE:3835908), complete cds. LF330046 - JP 2014500723-A/137549: Polycomb-Associated Non-Coding RNAs. LF330047 - JP 2014500723-A/137550: Polycomb-Associated Non-Coding RNAs. LF330050 - JP 2014500723-A/137553: Polycomb-Associated Non-Coding RNAs. LF330063 - JP 2014500723-A/137566: Polycomb-Associated Non-Coding RNAs. L40396 - Homo sapiens (clone s22i71) mRNA fragment. LF330066 - JP 2014500723-A/137569: Polycomb-Associated Non-Coding RNAs. LF330067 - JP 2014500723-A/137570: Polycomb-Associated Non-Coding RNAs. LF330068 - JP 2014500723-A/137571: Polycomb-Associated Non-Coding RNAs. JD299246 - Sequence 280270 from Patent EP1572962. MA565588 - JP 2018138019-A/137514: Polycomb-Associated Non-Coding RNAs. MA565589 - JP 2018138019-A/137515: Polycomb-Associated Non-Coding RNAs. MA565590 - JP 2018138019-A/137516: Polycomb-Associated Non-Coding RNAs. MA565592 - JP 2018138019-A/137518: Polycomb-Associated Non-Coding RNAs. MA565594 - JP 2018138019-A/137520: Polycomb-Associated Non-Coding RNAs. MA565605 - JP 2018138019-A/137531: Polycomb-Associated Non-Coding RNAs. MA565606 - JP 2018138019-A/137532: Polycomb-Associated Non-Coding RNAs. MA565607 - JP 2018138019-A/137533: Polycomb-Associated Non-Coding RNAs. MA565608 - JP 2018138019-A/137534: Polycomb-Associated Non-Coding RNAs. MA565609 - JP 2018138019-A/137535: Polycomb-Associated Non-Coding RNAs. MA565610 - JP 2018138019-A/137536: Polycomb-Associated Non-Coding RNAs. MA565611 - JP 2018138019-A/137537: Polycomb-Associated Non-Coding RNAs. MA565612 - JP 2018138019-A/137538: Polycomb-Associated Non-Coding RNAs. MA565613 - JP 2018138019-A/137539: Polycomb-Associated Non-Coding RNAs. MA565614 - JP 2018138019-A/137540: Polycomb-Associated Non-Coding RNAs. MA565617 - JP 2018138019-A/137543: Polycomb-Associated Non-Coding RNAs. MA565619 - JP 2018138019-A/137545: Polycomb-Associated Non-Coding RNAs. MA565621 - JP 2018138019-A/137547: Polycomb-Associated Non-Coding RNAs. MA565622 - JP 2018138019-A/137548: Polycomb-Associated Non-Coding RNAs. MA565623 - JP 2018138019-A/137549: Polycomb-Associated Non-Coding RNAs. MA565624 - JP 2018138019-A/137550: Polycomb-Associated Non-Coding RNAs. MA565627 - JP 2018138019-A/137553: Polycomb-Associated Non-Coding RNAs. MA565640 - JP 2018138019-A/137566: Polycomb-Associated Non-Coding RNAs. MA565643 - JP 2018138019-A/137569: Polycomb-Associated Non-Coding RNAs. MA565644 - JP 2018138019-A/137570: Polycomb-Associated Non-Coding RNAs. MA565645 - JP 2018138019-A/137571: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: C14orf170, ENST00000325680.1, ENST00000325680.10, ENST00000325680.11, ENST00000325680.2, ENST00000325680.3, ENST00000325680.4, ENST00000325680.5, ENST00000325680.6, ENST00000325680.7, ENST00000325680.8, ENST00000325680.9, NM_019589, P49750, P49752, Q96I64, Q9P1V7, uc317rxn.1, uc317rxn.2, YLPM1_HUMAN, ZAP3 UCSC ID: ENST00000325680.12_6 RefSeq Accession: NM_019589.3 Protein: P49750 (aka YLPM1_HUMAN or ZAP3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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