ID:YMEL1_HUMAN DESCRIPTION: RecName: Full=ATP-dependent zinc metalloprotease YME1L1; EC=3.4.24.-; AltName: Full=ATP-dependent metalloprotease FtsH1; AltName: Full=Meg-4; AltName: Full=Presenilin-associated metalloprotease; Short=PAMP; AltName: Full=YME1-like protein 1; FUNCTION: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. COFACTOR: Binds 1 zinc ion per subunit (Potential). SUBUNIT: Exists in several complexes of 600-1100 kDa. SUBCELLULAR LOCATION: Mitochondrion inner membrane. TISSUE SPECIFICITY: High expression in cardiac and skeletal muscle mitochondria. SIMILARITY: In the N-terminal section; belongs to the AAA ATPase family. SIMILARITY: In the C-terminal section; belongs to the peptidase M41 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96TA2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006508 proteolysis GO:0006515 misfolded or incompletely synthesized protein catabolic process GO:0007005 mitochondrion organization GO:0008283 cell proliferation GO:0034214 protein hexamerization GO:0034982 mitochondrial protein processing GO:0035694 mitochondrial protein catabolic process GO:0043066 negative regulation of apoptotic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
