Human Gene YWHAB (ENST00000353703.9_5) from GENCODE V47lift37
  Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta, transcript variant 2 (from RefSeq NM_139323.4)
Gencode Transcript: ENST00000353703.9_5
Gencode Gene: ENSG00000166913.13_9
Transcript (Including UTRs)
   Position: hg19 chr20:43,514,346-43,537,173 Size: 22,828 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr20:43,530,175-43,535,079 Size: 4,905 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:43,514,346-43,537,173)mRNA (may differ from genome)Protein (246 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: YWHAB
Diseases sorted by gene-association score: gerstmann-straussler disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 129.32 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 3182.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.50185-0.381 Picture PostScript Text
3' UTR -510.902094-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  EU794580 - Homo sapiens epididymis secretory protein Li 1 (HEL-S-1) mRNA, complete cds.
AK292717 - Homo sapiens cDNA FLJ75977 complete cds, highly similar to Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB), transcript variant 1, mRNA.
BC001359 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, mRNA (cDNA clone MGC:1580 IMAGE:3051079), complete cds.
AF064847 - Homo sapiens map 20q13.3; 51cR from D20S173 repeat region, complete sequence.
AL834170 - Homo sapiens mRNA; cDNA DKFZp762B1113 (from clone DKFZp762B1113).
AB209759 - Homo sapiens mRNA for tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide variant protein.
X57346 - H.sapiens mRNA for HS1 protein.
AB451386 - Homo sapiens YWHAB mRNA for 14-3-3 protein beta/alpha, partial cds, clone: FLJ08074AAAF.
AB529201 - Synthetic construct DNA, clone: pF1KB5474, Homo sapiens YWHAB gene for tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, without stop codon, in Flexi system.
EU832334 - Synthetic construct Homo sapiens clone HAIB:100067363; DKFZo008F0827 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide protein (YWHAB) gene, encodes complete protein.
EU832419 - Synthetic construct Homo sapiens clone HAIB:100067448; DKFZo004F0828 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide protein (YWHAB) gene, encodes complete protein.
KJ892394 - Synthetic construct Homo sapiens clone ccsbBroadEn_01788 YWHAB gene, encodes complete protein.
AB451260 - Homo sapiens YWHAB mRNA for 14-3-3 protein beta/alpha, complete cds, clone: FLJ08074AAAN.
JD027351 - Sequence 8375 from Patent EP1572962.
JD032290 - Sequence 13314 from Patent EP1572962.
JD021494 - Sequence 2518 from Patent EP1572962.
JD036209 - Sequence 17233 from Patent EP1572962.
JD021725 - Sequence 2749 from Patent EP1572962.
JD024667 - Sequence 5691 from Patent EP1572962.
JD031985 - Sequence 13009 from Patent EP1572962.
AF107406 - Homo sapiens GW128 mRNA, complete cds.
JD369706 - Sequence 350730 from Patent EP1572962.
BC010352 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, mRNA (cDNA clone IMAGE:4292790).
JD357905 - Sequence 338929 from Patent EP1572962.
JD026962 - Sequence 7986 from Patent EP1572962.
JD034450 - Sequence 15474 from Patent EP1572962.
JD154742 - Sequence 135766 from Patent EP1572962.
BC000883 - Homo sapiens cDNA clone IMAGE:3462232, **** WARNING: chimeric clone ****.
KJ901829 - Synthetic construct Homo sapiens clone ccsbBroadEn_11223 YWHAB gene, encodes complete protein.
JD143946 - Sequence 124970 from Patent EP1572962.
JD243122 - Sequence 224146 from Patent EP1572962.
JD201457 - Sequence 182481 from Patent EP1572962.
JD558829 - Sequence 539853 from Patent EP1572962.
JD338698 - Sequence 319722 from Patent EP1572962.
JD099976 - Sequence 81000 from Patent EP1572962.
JD136648 - Sequence 117672 from Patent EP1572962.
JD162100 - Sequence 143124 from Patent EP1572962.
JD495133 - Sequence 476157 from Patent EP1572962.
JD366420 - Sequence 347444 from Patent EP1572962.
JD117094 - Sequence 98118 from Patent EP1572962.
JD374618 - Sequence 355642 from Patent EP1572962.
JD562718 - Sequence 543742 from Patent EP1572962.
JD284315 - Sequence 265339 from Patent EP1572962.
JD113695 - Sequence 94719 from Patent EP1572962.
JD412246 - Sequence 393270 from Patent EP1572962.
JD510306 - Sequence 491330 from Patent EP1572962.
JD488108 - Sequence 469132 from Patent EP1572962.
JD047818 - Sequence 28842 from Patent EP1572962.
JD459526 - Sequence 440550 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY66-14 - MAP kinase cascade

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000353703.1, ENST00000353703.2, ENST00000353703.3, ENST00000353703.4, ENST00000353703.5, ENST00000353703.6, ENST00000353703.7, ENST00000353703.8, HEL-S-1 , NM_139323, uc317yks.1, uc317yks.2, V9HWD6, V9HWD6_HUMAN
UCSC ID: ENST00000353703.9_5
RefSeq Accession: NM_139323.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.