ID:TYY1_HUMAN DESCRIPTION: RecName: Full=Transcriptional repressor protein YY1; AltName: Full=Delta transcription factor; AltName: Full=INO80 complex subunit S; AltName: Full=NF-E1; AltName: Full=Yin and yang 1; Short=YY-1; FUNCTION: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. SUBUNIT: Interacts with YAF2 through the region encompassing the first and second zinc fingers. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex. INTERACTION: O96019:ACTL6A; NbExp=5; IntAct=EBI-765538, EBI-355018; P49407:ARRB1; NbExp=4; IntAct=EBI-765538, EBI-743313; Q9ULG1:INO80; NbExp=5; IntAct=EBI-765538, EBI-769345; P78527:PRKDC; NbExp=2; IntAct=EBI-765538, EBI-352053; Q9Y265:RUVBL1; NbExp=4; IntAct=EBI-765538, EBI-353675; Q9Y230:RUVBL2; NbExp=5; IntAct=EBI-765538, EBI-352939; Q8CCI5:Rybp (xeno); NbExp=2; IntAct=EBI-765538, EBI-929290; SUBCELLULAR LOCATION: Nucleus matrix. Note=Associated with the nuclear matrix. PTM: Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites. SIMILARITY: Belongs to the YY transcription factor family. SIMILARITY: Contains 4 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25490
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000400 four-way junction DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001158 enhancer sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0003723 RNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046332 SMAD binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000724 double-strand break repair via homologous recombination GO:0006281 DNA repair GO:0006310 DNA recombination GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006403 RNA localization GO:0006974 cellular response to DNA damage stimulus GO:0007283 spermatogenesis GO:0009952 anterior/posterior pattern specification GO:0010225 response to UV-C GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0016579 protein deubiquitination GO:0030154 cell differentiation GO:0032688 negative regulation of interferon-beta production GO:0034644 cellular response to UV GO:0034696 response to prostaglandin F GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048593 camera-type eye morphogenesis GO:0051276 chromosome organization GO:0071347 cellular response to interleukin-1 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter
Z14077 - H.sapiens mRNA for YY1/NF-E1 protein. M77698 - Homo sapiens GLI-Krupple related protein (YY1) mRNA, complete cds. JD128842 - Sequence 109866 from Patent EP1572962. JD129771 - Sequence 110795 from Patent EP1572962. BC037308 - Homo sapiens YY1 transcription factor, mRNA (cDNA clone MGC:41844 IMAGE:5261384), complete cds. M76541 - Human DNA-binding protein (NF-E1) mRNA, complete cds. BC020324 - Homo sapiens YY1 transcription factor, mRNA (cDNA clone IMAGE:3859359). BC065366 - Homo sapiens YY1 transcription factor, mRNA (cDNA clone MGC:71152 IMAGE:5815774), complete cds. JD127963 - Sequence 108987 from Patent EP1572962. JD142424 - Sequence 123448 from Patent EP1572962. JD205789 - Sequence 186813 from Patent EP1572962. AB464361 - Synthetic construct DNA, clone: pF1KB7701, Homo sapiens YY1 gene for YY1 transcription factor, without stop codon, in Flexi system. DQ891638 - Synthetic construct clone IMAGE:100004268; FLH178874.01X; RZPDo839A03130D YY1 transcription factor (YY1) gene, encodes complete protein. EU176600 - Synthetic construct Homo sapiens clone IMAGE:100011424; FLH178873.01L; RZPDo839B04254D YY1 transcription factor (YY1) gene, encodes complete protein. CU691478 - Synthetic construct Homo sapiens gateway clone IMAGE:100019288 5' read YY1 mRNA. KJ897747 - Synthetic construct Homo sapiens clone ccsbBroadEn_07141 YY1 gene, encodes complete protein. JD364230 - Sequence 345254 from Patent EP1572962. JD110950 - Sequence 91974 from Patent EP1572962. BX647456 - Homo sapiens mRNA; cDNA DKFZp313L1711 (from clone DKFZp313L1711). JD237297 - Sequence 218321 from Patent EP1572962. JD057789 - Sequence 38813 from Patent EP1572962. JD276860 - Sequence 257884 from Patent EP1572962. JD438727 - Sequence 419751 from Patent EP1572962. JD271863 - Sequence 252887 from Patent EP1572962. JD501761 - Sequence 482785 from Patent EP1572962. JD042973 - Sequence 23997 from Patent EP1572962. JD501924 - Sequence 482948 from Patent EP1572962. AF147416 - Homo sapiens full length insert cDNA clone YP61F07. JD244983 - Sequence 226007 from Patent EP1572962. AK025731 - Homo sapiens cDNA: FLJ22078 fis, clone HEP13057. JD192747 - Sequence 173771 from Patent EP1572962. JD366883 - Sequence 347907 from Patent EP1572962. JD509046 - Sequence 490070 from Patent EP1572962. JD082137 - Sequence 63161 from Patent EP1572962. JD037327 - Sequence 18351 from Patent EP1572962. AK026497 - Homo sapiens cDNA: FLJ22844 fis, clone KAIA5181. JD485275 - Sequence 466299 from Patent EP1572962. JD159260 - Sequence 140284 from Patent EP1572962. JD539557 - Sequence 520581 from Patent EP1572962. JD315581 - Sequence 296605 from Patent EP1572962. JD257006 - Sequence 238030 from Patent EP1572962. JD421444 - Sequence 402468 from Patent EP1572962. BC051735 - Homo sapiens cDNA clone IMAGE:4797512. JD349265 - Sequence 330289 from Patent EP1572962. JD304798 - Sequence 285822 from Patent EP1572962. JD084602 - Sequence 65626 from Patent EP1572962. JD276713 - Sequence 257737 from Patent EP1572962. JD103050 - Sequence 84074 from Patent EP1572962. JD365391 - Sequence 346415 from Patent EP1572962. JD200934 - Sequence 181958 from Patent EP1572962. JD154983 - Sequence 136007 from Patent EP1572962. JD346212 - Sequence 327236 from Patent EP1572962. JD403214 - Sequence 384238 from Patent EP1572962. JD466962 - Sequence 447986 from Patent EP1572962. JD068801 - Sequence 49825 from Patent EP1572962. JD042243 - Sequence 23267 from Patent EP1572962. JD324713 - Sequence 305737 from Patent EP1572962. JD528440 - Sequence 509464 from Patent EP1572962. JD511174 - Sequence 492198 from Patent EP1572962. JD561603 - Sequence 542627 from Patent EP1572962. JD164168 - Sequence 145192 from Patent EP1572962. BC014138 - Homo sapiens cDNA clone IMAGE:4648861, partial cds. JD389303 - Sequence 370327 from Patent EP1572962. JD358504 - Sequence 339528 from Patent EP1572962. JD473041 - Sequence 454065 from Patent EP1572962. JD446001 - Sequence 427025 from Patent EP1572962. JD161970 - Sequence 142994 from Patent EP1572962. JD328531 - Sequence 309555 from Patent EP1572962. JD239358 - Sequence 220382 from Patent EP1572962. JD094845 - Sequence 75869 from Patent EP1572962. JD551373 - Sequence 532397 from Patent EP1572962. JD393240 - Sequence 374264 from Patent EP1572962. JD172374 - Sequence 153398 from Patent EP1572962. JD111609 - Sequence 92633 from Patent EP1572962. JD083396 - Sequence 64420 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_prc2Pathway - The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails
Reactome (by CSHL, EBI, and GO)
Protein P25490 (Reactome details) participates in the following event(s):
R-HSA-8864453 TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 R-HSA-9009065 FOXA1 and GATA3 bind to CCND1 promoter R-HSA-5689544 UCHL5 binds INO80 complex R-HSA-5689630 BAP1 binds BAP1-interacting complex R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-9018519 Estrogen-dependent gene expression R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5689603 UCH proteinases R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8939211 ESR-mediated signaling R-HSA-5619507 Activation of HOX genes during differentiation R-HSA-5688426 Deubiquitination R-HSA-212436 Generic Transcription Pathway R-HSA-9006931 Signaling by Nuclear Receptors R-HSA-1266738 Developmental Biology R-HSA-597592 Post-translational protein modification R-HSA-73857 RNA Polymerase II Transcription R-HSA-162582 Signal Transduction R-HSA-392499 Metabolism of proteins R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
