ID:ZBT16_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 16; AltName: Full=Promyelocytic leukemia zinc finger protein; AltName: Full=Zinc finger protein 145; AltName: Full=Zinc finger protein PLZF; FUNCTION: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Binds EPN1. Interacts with ZBTB32 and CUL3. INTERACTION: Self; NbExp=2; IntAct=EBI-711925, EBI-711925; P68104:EEF1A1; NbExp=4; IntAct=EBI-711925, EBI-352162; P29590:PML; NbExp=7; IntAct=EBI-711925, EBI-295890; P29590-5:PML; NbExp=2; IntAct=EBI-711925, EBI-304008; Q9NYJ8:TAB2; NbExp=3; IntAct=EBI-711925, EBI-358708; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung. INDUCTION: By retinoic acid. DISEASE: Defects in ZBTB16 are the cause of skeletal defects genital hypoplasia and mental retardation (SGYMR) [MIM:612447]. A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia. DISEASE: Note=A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 9 C2H2-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLZF37.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q05516
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0019904 protein domain specific binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001501 skeletal system development GO:0001823 mesonephros development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0007417 central nervous system development GO:0008285 negative regulation of cell proliferation GO:0009880 embryonic pattern specification GO:0009952 anterior/posterior pattern specification GO:0016567 protein ubiquitination GO:0030097 hemopoiesis GO:0030099 myeloid cell differentiation GO:0032332 positive regulation of chondrocyte differentiation GO:0034504 protein localization to nucleus GO:0035116 embryonic hindlimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0042733 embryonic digit morphogenesis GO:0043065 positive regulation of apoptotic process GO:0043687 post-translational protein modification GO:0045600 positive regulation of fat cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045778 positive regulation of ossification GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0048133 male germ-line stem cell asymmetric division GO:0051138 positive regulation of NK T cell differentiation GO:0051216 cartilage development GO:0061036 positive regulation of cartilage development
BX648973 - Homo sapiens mRNA; cDNA DKFZp686F2164 (from clone DKFZp686F2164). AB208916 - Homo sapiens mRNA for zinc finger and BTB domain containing 16 variant protein. BC029812 - Homo sapiens zinc finger and BTB domain containing 16, mRNA (cDNA clone MGC:35284 IMAGE:5175961), complete cds. BC026902 - Homo sapiens zinc finger and BTB domain containing 16, mRNA (cDNA clone MGC:24908 IMAGE:4944546), complete cds. Z19002 - H.sapiens of PLZF gene encoding kruppel-like zinc finger protein. EU446725 - Synthetic construct Homo sapiens clone IMAGE:100069857; IMAGE:100011934; FLH258581.01L zinc finger and BTB domain containing 16 (ZBTB16) gene, encodes complete protein. AB527720 - Synthetic construct DNA, clone: pF1KB6229, Homo sapiens ZBTB16 gene for zinc finger and BTB domain containing 16, without stop codon, in Flexi system. KJ897771 - Synthetic construct Homo sapiens clone ccsbBroadEn_07165 ZBTB16 gene, encodes complete protein. KU178400 - Homo sapiens zinc finger and BTB domain containing 16 isoform 1 (ZBTB16) mRNA, partial cds. KU178401 - Homo sapiens zinc finger and BTB domain containing 16 isoform 2 (ZBTB16) mRNA, partial cds, alternatively spliced. JD496268 - Sequence 477292 from Patent EP1572962. JD554717 - Sequence 535741 from Patent EP1572962. JD100322 - Sequence 81346 from Patent EP1572962. JD537982 - Sequence 519006 from Patent EP1572962. DM107525 - METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL. HW120529 - JP 2013049691-A/84: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL. LF858632 - JP 2015172074-A/84: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL. JD407412 - Sequence 388436 from Patent EP1572962. DQ596438 - Homo sapiens piRNA piR-34504, complete sequence. MA725982 - JP 2017114907-A/84: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_egfr_smrtePathway - Map Kinase Inactivation of SMRT Corepressor
Reactome (by CSHL, EBI, and GO)
Protein Q05516 (Reactome details) participates in the following event(s):
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-597592 Post-translational protein modification R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-392499 Metabolism of proteins R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
