Human Gene ZBTB2 (ENST00000325144.5_7) from GENCODE V47lift37
  Description: zinc finger and BTB domain containing 2 (from RefSeq NM_020861.3)
Gencode Transcript: ENST00000325144.5_7
Gencode Gene: ENSG00000181472.5_9
Transcript (Including UTRs)
   Position: hg19 chr6:151,685,250-151,712,694 Size: 27,445 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr6:151,686,656-151,694,772 Size: 8,117 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:151,685,250-151,712,694)mRNA (may differ from genome)Protein (514 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZBTB2_HUMAN
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 2;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 4 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.82 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 237.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.00152-0.447 Picture PostScript Text
3' UTR -298.301406-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on Q8N680
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC020172 - Homo sapiens zinc finger and BTB domain containing 2, mRNA (cDNA clone MGC:20189 IMAGE:4577244), complete cds.
AK092886 - Homo sapiens cDNA FLJ35567 fis, clone SPLEN2005560, moderately similar to ZINC FINGER PROTEIN 46.
AX747790 - Sequence 1315 from Patent EP1308459.
AJ420526 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2096173.
AB040916 - Homo sapiens mRNA for KIAA1483 protein, partial cds.
AL832957 - Homo sapiens mRNA; cDNA DKFZp666M0210 (from clone DKFZp666M0210).
JD339778 - Sequence 320802 from Patent EP1572962.
JD313509 - Sequence 294533 from Patent EP1572962.
JD501224 - Sequence 482248 from Patent EP1572962.
JD159986 - Sequence 141010 from Patent EP1572962.
JD285018 - Sequence 266042 from Patent EP1572962.
JD488695 - Sequence 469719 from Patent EP1572962.
JD352232 - Sequence 333256 from Patent EP1572962.
AK291942 - Homo sapiens cDNA FLJ77577 complete cds, highly similar to Homo sapiens zinc finger and BTB domain containing 2 (ZBTB2), mRNA.
JD043323 - Sequence 24347 from Patent EP1572962.
JD316131 - Sequence 297155 from Patent EP1572962.
EU446836 - Synthetic construct Homo sapiens clone IMAGE:100070165; IMAGE:100012045; FLH257428.01L zinc finger and BTB domain containing 2 (ZBTB2) gene, encodes complete protein.
AB464747 - Synthetic construct DNA, clone: pF1KB7051, Homo sapiens ZBTB2 gene for zinc finger and BTB domain containing protein 2, without stop codon, in Flexi system.
JD106299 - Sequence 87323 from Patent EP1572962.
JD068399 - Sequence 49423 from Patent EP1572962.
JD370498 - Sequence 351522 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7C7, ENST00000325144.1, ENST00000325144.2, ENST00000325144.3, ENST00000325144.4, KIAA1483, NM_020861, Q5SZ81, Q8N680, Q9P245, uc317ruu.1, uc317ruu.2, ZBTB2_HUMAN, ZNF437
UCSC ID: ENST00000325144.5_7
RefSeq Accession: NM_020861.3
Protein: Q8N680 (aka ZBTB2_HUMAN or ZBT2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.