Human Gene ZBTB39 (ENST00000300101.3_7) from GENCODE V47lift37

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Description: zinc finger and BTB domain containing 39 (from RefSeq NM_014830.3)
Gencode Transcript: ENST00000300101.3_7
Gencode Gene: ENSG00000166860.3_9
Transcript (Including UTRs)
Position: hg19 chr12:57,392,620-57,400,330 Size: 7,711 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr12:57,396,563-57,398,701 Size: 2,139 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:57,392,620-57,400,330)			mRNA (may differ from genome)		Protein (712 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZBT39_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 39; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 8 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAA20809.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D019256 Cadmium Chloride D018817 N-Methyl-3,4-methylenedioxyamphetamine D013749 Tetrachlorodibenzodioxin C069837 fullerene C60 C028007 nickel monoxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.83 RPKM in Testis Total median expression: 86.56 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-86.90	186	-0.467	Picture	PostScript	Text
3' UTR	-1261.10	3943	-0.320	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF12874 - Zinc-finger of C2H2 type

SCOP Domains:
54695 - POZ domain
82657 - BolA-like
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on O15060


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	KJ892870 - Synthetic construct Homo sapiens clone ccsbBroadEn_02264 ZBTB39 gene, encodes complete protein. AK311025 - Homo sapiens cDNA, FLJ18067. BC152461 - Homo sapiens zinc finger and BTB domain containing 39, mRNA (cDNA clone MGC:176718 IMAGE:8862597), complete cds. AB002350 - Homo sapiens mRNA for KIAA0352 gene. JD550804 - Sequence 531828 from Patent EP1572962. JD311329 - Sequence 292353 from Patent EP1572962. JD325300 - Sequence 306324 from Patent EP1572962. JD077992 - Sequence 59016 from Patent EP1572962. JD243882 - Sequence 224906 from Patent EP1572962. JD347158 - Sequence 328182 from Patent EP1572962. JD243851 - Sequence 224875 from Patent EP1572962. JD184960 - Sequence 165984 from Patent EP1572962. JD152648 - Sequence 133672 from Patent EP1572962. JD531138 - Sequence 512162 from Patent EP1572962. JD496156 - Sequence 477180 from Patent EP1572962. JD344122 - Sequence 325146 from Patent EP1572962. JD508824 - Sequence 489848 from Patent EP1572962. JD212113 - Sequence 193137 from Patent EP1572962. JD355663 - Sequence 336687 from Patent EP1572962. JD396423 - Sequence 377447 from Patent EP1572962. JD474322 - Sequence 455346 from Patent EP1572962. JD055335 - Sequence 36359 from Patent EP1572962. JD533233 - Sequence 514257 from Patent EP1572962. JD231717 - Sequence 212741 from Patent EP1572962. JD223336 - Sequence 204360 from Patent EP1572962. JD154003 - Sequence 135027 from Patent EP1572962. JD268651 - Sequence 249675 from Patent EP1572962. JD288695 - Sequence 269719 from Patent EP1572962. JD275046 - Sequence 256070 from Patent EP1572962. JD046608 - Sequence 27632 from Patent EP1572962. JD094042 - Sequence 75066 from Patent EP1572962. JD379572 - Sequence 360596 from Patent EP1572962. JD438794 - Sequence 419818 from Patent EP1572962. BC140890 - Homo sapiens zinc finger and BTB domain containing 39, mRNA (cDNA clone MGC:176567 IMAGE:9021758), complete cds. BC146867 - Homo sapiens zinc finger and BTB domain containing 39, mRNA (cDNA clone MGC:181970 IMAGE:9056795), complete cds. JD078054 - Sequence 59078 from Patent EP1572962. JD384857 - Sequence 365881 from Patent EP1572962. JD565029 - Sequence 546053 from Patent EP1572962. JD566921 - Sequence 547945 from Patent EP1572962. JD404266 - Sequence 385290 from Patent EP1572962. JD085180 - Sequence 66204 from Patent EP1572962. JD555977 - Sequence 537001 from Patent EP1572962. JD203291 - Sequence 184315 from Patent EP1572962. JD549003 - Sequence 530027 from Patent EP1572962. JD060603 - Sequence 41627 from Patent EP1572962. JD559375 - Sequence 540399 from Patent EP1572962. JD454229 - Sequence 435253 from Patent EP1572962. JD232559 - Sequence 213583 from Patent EP1572962. JD386151 - Sequence 367175 from Patent EP1572962. JD131657 - Sequence 112681 from Patent EP1572962. JD038557 - Sequence 19581 from Patent EP1572962. JD392396 - Sequence 373420 from Patent EP1572962. JD534333 - Sequence 515357 from Patent EP1572962. JD164207 - Sequence 145231 from Patent EP1572962. JD284300 - Sequence 265324 from Patent EP1572962. JD296122 - Sequence 277146 from Patent EP1572962. JD091586 - Sequence 72610 from Patent EP1572962. JD064688 - Sequence 45712 from Patent EP1572962. JD382403 - Sequence 363427 from Patent EP1572962. JD094669 - Sequence 75693 from Patent EP1572962. JD248495 - Sequence 229519 from Patent EP1572962. JD295204 - Sequence 276228 from Patent EP1572962. JD161757 - Sequence 142781 from Patent EP1572962. JD448796 - Sequence 429820 from Patent EP1572962. JD254961 - Sequence 235985 from Patent EP1572962. JD093555 - Sequence 74579 from Patent EP1572962. JD323338 - Sequence 304362 from Patent EP1572962. JD490874 - Sequence 471898 from Patent EP1572962. JD342978 - Sequence 324002 from Patent EP1572962. JD280603 - Sequence 261627 from Patent EP1572962. JD551323 - Sequence 532347 from Patent EP1572962. JD105519 - Sequence 86543 from Patent EP1572962. JD497046 - Sequence 478070 from Patent EP1572962. JD346963 - Sequence 327987 from Patent EP1572962. JD227188 - Sequence 208212 from Patent EP1572962. JD077704 - Sequence 58728 from Patent EP1572962. JD334588 - Sequence 315612 from Patent EP1572962. JD263142 - Sequence 244166 from Patent EP1572962. JD467849 - Sequence 448873 from Patent EP1572962. JD473133 - Sequence 454157 from Patent EP1572962. JD473132 - Sequence 454156 from Patent EP1572962. JD340418 - Sequence 321442 from Patent EP1572962. AK292468 - Homo sapiens cDNA FLJ76063 complete cds, highly similar to Homo sapiens zinc finger and BTB domain containing 39 (ZBTB39), mRNA. JD061436 - Sequence 42460 from Patent EP1572962. JD329382 - Sequence 310406 from Patent EP1572962. JD516581 - Sequence 497605 from Patent EP1572962. JD217916 - Sequence 198940 from Patent EP1572962. JD132402 - Sequence 113426 from Patent EP1572962. JD286267 - Sequence 267291 from Patent EP1572962. JD565151 - Sequence 546175 from Patent EP1572962. JD334772 - Sequence 315796 from Patent EP1572962. JD057889 - Sequence 38913 from Patent EP1572962. AB383856 - Synthetic construct DNA, clone: pF1KSDA0352, Homo sapiens ZBTB39 gene for zinc finger and BTB domain-containing protein 39, complete cds, without stop codon, in Flexi system. DQ600081 - Homo sapiens piRNA piR-38147, complete sequence. JD406013 - Sequence 387037 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A7MD38, ENST00000300101.1, ENST00000300101.2, KIAA0352, NM_014830, O15060, Q9UD98, uc317mnp.1, uc317mnp.2, ZBT39_HUMAN UCSC ID: ENST00000300101.3_7 RefSeq Accession: NM_014830.3 Protein: O15060 (aka ZBT39_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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