ID:ZBTB4_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 4; AltName: Full=KAISO-like zinc finger protein 1; Short=KAISO-L1; FUNCTION: May be involved in transcriptional regulation. SUBUNIT: Interacts with HIPK2. SUBCELLULAR LOCATION: Nucleus (Potential). PTM: Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAA96062.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P1Z0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0008327 methyl-CpG binding GO:0010428 methyl-CpNpG binding GO:0019901 protein kinase binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006974 cellular response to DNA damage stimulus GO:0045892 negative regulation of transcription, DNA-templated
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
