Human Gene ZC3H7A (ENST00000355758.9_7) from GENCODE V47lift37
  Description: zinc finger CCCH-type containing 7A (from RefSeq NM_014153.4)
Gencode Transcript: ENST00000355758.9_7
Gencode Gene: ENSG00000122299.12_14
Transcript (Including UTRs)
   Position: hg19 chr16:11,844,453-11,891,114 Size: 46,662 Total Exon Count: 23 Strand: -
Coding Region
   Position: hg19 chr16:11,845,173-11,876,210 Size: 31,038 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:11,844,453-11,891,114)mRNA (may differ from genome)Protein (971 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Z3H7A_HUMAN
DESCRIPTION: RecName: Full=Zinc finger CCCH domain-containing protein 7A;
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Contains 1 C2H2-type zinc finger.
SIMILARITY: Contains 3 C3H1-type zinc fingers.
SIMILARITY: Contains 3 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.27 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 549.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.20169-0.356 Picture PostScript Text
3' UTR -178.00720-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011990 - TPR-like_helical
IPR015880 - Znf_C2H2-like
IPR000571 - Znf_CCCH

Pfam Domains:
PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PF12874 - Zinc-finger of C2H2 type
PF14608 - RNA-binding, Nab2-type zinc finger

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
57667 - beta-beta-alpha zinc fingers
90229 - CCCH zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2D9M - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q8IWR0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0035198 miRNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0010608 posttranscriptional regulation of gene expression
GO:0035196 production of miRNAs involved in gene silencing by miRNA

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK026956 - Homo sapiens cDNA: FLJ23303 fis, clone HEP11157, highly similar to AF161540 Homo sapiens HSPC055 mRNA.
AY163807 - Homo sapiens zinc-finger protein mRNA, complete cds.
AK001869 - Homo sapiens cDNA FLJ11007 fis, clone PLACE1003092.
BX647154 - Homo sapiens mRNA; cDNA DKFZp686H18275 (from clone DKFZp686H18275).
AF161540 - Homo sapiens HSPC055 mRNA, complete cds.
AK026827 - Homo sapiens cDNA: FLJ23174 fis, clone LNG10049, highly similar to AF161540 Homo sapiens HSPC055 mRNA.
BC012575 - Homo sapiens zinc finger CCCH-type containing 7A, mRNA (cDNA clone IMAGE:4291095), complete cds.
BC046363 - Homo sapiens zinc finger CCCH-type containing 7A, mRNA (cDNA clone MGC:50782 IMAGE:5538820), complete cds.
AK000889 - Homo sapiens cDNA FLJ10027 fis, clone HEMBA1000727.
JD503401 - Sequence 484425 from Patent EP1572962.
JD562730 - Sequence 543754 from Patent EP1572962.
JD094238 - Sequence 75262 from Patent EP1572962.
JD559092 - Sequence 540116 from Patent EP1572962.
JD174557 - Sequence 155581 from Patent EP1572962.
JD524496 - Sequence 505520 from Patent EP1572962.
JD278567 - Sequence 259591 from Patent EP1572962.
JD029472 - Sequence 10496 from Patent EP1572962.
JD021016 - Sequence 2040 from Patent EP1572962.
JD254115 - Sequence 235139 from Patent EP1572962.
JD304191 - Sequence 285215 from Patent EP1572962.
KJ902500 - Synthetic construct Homo sapiens clone ccsbBroadEn_11894 ZC3H7A gene, encodes complete protein.
AK000325 - Homo sapiens cDNA FLJ20318 fis, clone HEP08704.
AK091803 - Homo sapiens cDNA FLJ34484 fis, clone HLUNG2004159, weakly similar to Ubiquitous tetratricopeptide containing protein RoXaN.
AX747194 - Sequence 719 from Patent EP1308459.
BC036857 - Homo sapiens zinc finger CCCH-type containing 7A, mRNA (cDNA clone IMAGE:5527491), partial cds.
JD458495 - Sequence 439519 from Patent EP1572962.
JD458496 - Sequence 439520 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DUG5, ENST00000355758.1, ENST00000355758.2, ENST00000355758.3, ENST00000355758.4, ENST00000355758.5, ENST00000355758.6, ENST00000355758.7, ENST00000355758.8, HSPC055, NM_014153, Q8IWR0, Q9NPE9, uc317zfw.1, uc317zfw.2, Z3H7A_HUMAN, ZC3H7, ZC3HDC7
UCSC ID: ENST00000355758.9_7
RefSeq Accession: NM_014153.4
Protein: Q8IWR0 (aka Z3H7A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.