Human Gene ZDHHC3 (ENST00000424952.7_7) from GENCODE V47lift37
  Description: zinc finger DHHC-type palmitoyltransferase 3, transcript variant 12 (from RefSeq NR_146162.2)
Gencode Transcript: ENST00000424952.7_7
Gencode Gene: ENSG00000163812.16_15
Transcript (Including UTRs)
   Position: hg19 chr3:44,956,753-45,017,666 Size: 60,914 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr3:44,968,181-45,000,928 Size: 32,748 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:44,956,753-45,017,666)mRNA (may differ from genome)Protein (299 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZDHC3_HUMAN
DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC3; EC=2.3.1.-; AltName: Full=Protein DHHC1; AltName: Full=Zinc finger DHHC domain-containing protein 3; Short=DHHC-3; AltName: Full=Zinc finger protein 373;
FUNCTION: Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity).
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein (By similarity).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
PTM: Autopalmitoylated (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.79 RPKM in Testis
Total median expression: 496.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -139.20266-0.523 Picture PostScript Text
3' UTR -3916.7011428-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q9NYG2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0006605 protein targeting
GO:0018345 protein palmitoylation

Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK000216 - Homo sapiens cDNA FLJ20209 fis, clone COLF1740.
AL832057 - Homo sapiens mRNA; cDNA DKFZp313D2314 (from clone DKFZp313D2314).
AK127837 - Homo sapiens cDNA FLJ45940 fis, clone PLACE7005840.
JD309965 - Sequence 290989 from Patent EP1572962.
JD528355 - Sequence 509379 from Patent EP1572962.
JD382791 - Sequence 363815 from Patent EP1572962.
JD488230 - Sequence 469254 from Patent EP1572962.
JD526956 - Sequence 507980 from Patent EP1572962.
JD055751 - Sequence 36775 from Patent EP1572962.
JD431435 - Sequence 412459 from Patent EP1572962.
JD299817 - Sequence 280841 from Patent EP1572962.
JD383432 - Sequence 364456 from Patent EP1572962.
JD154686 - Sequence 135710 from Patent EP1572962.
JD171544 - Sequence 152568 from Patent EP1572962.
JD227394 - Sequence 208418 from Patent EP1572962.
JD363826 - Sequence 344850 from Patent EP1572962.
JD468665 - Sequence 449689 from Patent EP1572962.
DQ578074 - Homo sapiens piRNA piR-46186, complete sequence.
JD320786 - Sequence 301810 from Patent EP1572962.
JD410515 - Sequence 391539 from Patent EP1572962.
JD113033 - Sequence 94057 from Patent EP1572962.
JD372039 - Sequence 353063 from Patent EP1572962.
JD328386 - Sequence 309410 from Patent EP1572962.
JD052221 - Sequence 33245 from Patent EP1572962.
JD101291 - Sequence 82315 from Patent EP1572962.
JD386564 - Sequence 367588 from Patent EP1572962.
JD177560 - Sequence 158584 from Patent EP1572962.
JD248277 - Sequence 229301 from Patent EP1572962.
JD195109 - Sequence 176133 from Patent EP1572962.
JD399828 - Sequence 380852 from Patent EP1572962.
JD041926 - Sequence 22950 from Patent EP1572962.
JD196955 - Sequence 177979 from Patent EP1572962.
JD191012 - Sequence 172036 from Patent EP1572962.
JD302909 - Sequence 283933 from Patent EP1572962.
JD339090 - Sequence 320114 from Patent EP1572962.
JD090380 - Sequence 71404 from Patent EP1572962.
JD497939 - Sequence 478963 from Patent EP1572962.
JD077114 - Sequence 58138 from Patent EP1572962.
BC113070 - Homo sapiens cDNA clone IMAGE:40024471.
BC101284 - Homo sapiens cDNA clone IMAGE:40024466.
BC101285 - Homo sapiens cDNA clone IMAGE:40024467.
BC101286 - Homo sapiens cDNA clone IMAGE:40024468.
BC101287 - Homo sapiens cDNA clone IMAGE:40024469.
JD437948 - Sequence 418972 from Patent EP1572962.
JD201625 - Sequence 182649 from Patent EP1572962.
JD085912 - Sequence 66936 from Patent EP1572962.
AK299782 - Homo sapiens cDNA FLJ57791 complete cds, highly similar to Palmitoyltransferase ZDHHC3 (EC 2.3.1.-).
JD345795 - Sequence 326819 from Patent EP1572962.
JD138714 - Sequence 119738 from Patent EP1572962.
JD084508 - Sequence 65532 from Patent EP1572962.
JD341172 - Sequence 322196 from Patent EP1572962.
JD127422 - Sequence 108446 from Patent EP1572962.
JD095145 - Sequence 76169 from Patent EP1572962.
JD427347 - Sequence 408371 from Patent EP1572962.
JD204754 - Sequence 185778 from Patent EP1572962.
JD451333 - Sequence 432357 from Patent EP1572962.
JD459725 - Sequence 440749 from Patent EP1572962.
JD550061 - Sequence 531085 from Patent EP1572962.
JD522517 - Sequence 503541 from Patent EP1572962.
JD414722 - Sequence 395746 from Patent EP1572962.
JD414721 - Sequence 395745 from Patent EP1572962.
JD069712 - Sequence 50736 from Patent EP1572962.
JD476688 - Sequence 457712 from Patent EP1572962.
JD069711 - Sequence 50735 from Patent EP1572962.
JD241877 - Sequence 222901 from Patent EP1572962.
JD513889 - Sequence 494913 from Patent EP1572962.
JD513890 - Sequence 494914 from Patent EP1572962.
BC020350 - Homo sapiens zinc finger, DHHC-type containing 3, mRNA (cDNA clone IMAGE:4177492).
BC020424 - Homo sapiens zinc finger, DHHC-type containing 3, mRNA (cDNA clone IMAGE:4177512).
BC038436 - Homo sapiens zinc finger, DHHC-type containing 3, mRNA (cDNA clone IMAGE:4177435).
AF247703 - Homo sapiens DHHC1 protein mRNA, complete cds.
AF052182 - Homo sapiens clone 24590 mRNA sequence.
JD156894 - Sequence 137918 from Patent EP1572962.
JD237604 - Sequence 218628 from Patent EP1572962.
JD344874 - Sequence 325898 from Patent EP1572962.
JD166221 - Sequence 147245 from Patent EP1572962.
JD515841 - Sequence 496865 from Patent EP1572962.
JD499120 - Sequence 480144 from Patent EP1572962.
JD264274 - Sequence 245298 from Patent EP1572962.
JD528519 - Sequence 509543 from Patent EP1572962.
JD555620 - Sequence 536644 from Patent EP1572962.
JD248024 - Sequence 229048 from Patent EP1572962.
JD133999 - Sequence 115023 from Patent EP1572962.
JD391762 - Sequence 372786 from Patent EP1572962.
JD471750 - Sequence 452774 from Patent EP1572962.
JD118416 - Sequence 99440 from Patent EP1572962.
JD334765 - Sequence 315789 from Patent EP1572962.
JD484253 - Sequence 465277 from Patent EP1572962.
JD323187 - Sequence 304211 from Patent EP1572962.
JD467269 - Sequence 448293 from Patent EP1572962.
JD368577 - Sequence 349601 from Patent EP1572962.
JD562557 - Sequence 543581 from Patent EP1572962.
BC015467 - Homo sapiens zinc finger, DHHC-type containing 3, mRNA (cDNA clone MGC:8765 IMAGE:3852521), complete cds.
EU831964 - Synthetic construct Homo sapiens clone HAIB:100066993; DKFZo008F0523 zinc finger, DHHC-type containing 3 protein (ZDHHC3) gene, encodes complete protein.
GQ129399 - Synthetic construct Homo sapiens clone HAIB:100068609; DKFZo008F0835 zinc finger, DHHC-type containing 3 protein (ZDHHC3) gene, complete cds.
AF441791 - Homo sapiens DHHC1 protein mRNA, complete cds.
EU832057 - Synthetic construct Homo sapiens clone HAIB:100067086; DKFZo004F0524 zinc finger, DHHC-type containing 3 protein (ZDHHC3) gene, encodes complete protein.
GQ129398 - Synthetic construct Homo sapiens clone HAIB:100068706; DKFZo004F0836 zinc finger, DHHC-type containing 3 protein (ZDHHC3) gene, partial cds.
AB527464 - Synthetic construct DNA, clone: pF1KB7643, Homo sapiens ZDHHC3 gene for zinc finger, DHHC-type containing 3, without stop codon, in Flexi system.
AY605661 - Homo sapiens HSD49 mRNA, partial cds.
JD215424 - Sequence 196448 from Patent EP1572962.
JD535893 - Sequence 516917 from Patent EP1572962.
JD159364 - Sequence 140388 from Patent EP1572962.
JD128195 - Sequence 109219 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000424952.1, ENST00000424952.2, ENST00000424952.3, ENST00000424952.4, ENST00000424952.5, ENST00000424952.6, HSD49 , NR_146162, Q53A17, Q96BL0, Q9NYG2, uc319uer.1, uc319uer.2, ZDHC3_HUMAN, ZDHHC3
UCSC ID: ENST00000424952.7_7
RefSeq Accession: NM_001135179.2
Protein: Q9NYG2 (aka ZDHC3_HUMAN or ZDH3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.