ID:ZFHX3_HUMAN DESCRIPTION: RecName: Full=Zinc finger homeobox protein 3; AltName: Full=AT motif-binding factor; AltName: Full=AT-binding transcription factor 1; AltName: Full=Alpha-fetoprotein enhancer-binding protein; AltName: Full=Zinc finger homeodomain protein 3; Short=ZFH-3; FUNCTION: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer. SUBUNIT: Interacts with FNBP3 (By similarity). Interacts with PIAS3. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. POLYMORPHISM: Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry. SIMILARITY: Contains 22 C2H2-type zinc fingers. SIMILARITY: Contains 4 homeobox DNA-binding domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ATBF1ID357.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15911
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0019899 enzyme binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007517 muscle organ development GO:0032922 circadian regulation of gene expression GO:0045662 negative regulation of myoblast differentiation GO:0045663 positive regulation of myoblast differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0071559 response to transforming growth factor beta GO:1904059 regulation of locomotor rhythm
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
