ID:TISD_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 36, C3H1 type-like 2; Short=ZFP36-like 2; AltName: Full=Butyrate response factor 2; AltName: Full=EGF-response factor 2; Short=ERF-2; AltName: Full=Protein TIS11D; FUNCTION: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Contains 2 C3H1-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P47974
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003723 RNA binding GO:0005515 protein binding GO:0017091 AU-rich element binding GO:0035925 mRNA 3'-UTR AU-rich region binding GO:0046872 metal ion binding
Biological Process: GO:0000165 MAPK cascade GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006402 mRNA catabolic process GO:0007275 multicellular organism development GO:0008283 cell proliferation GO:0009611 response to wounding GO:0030097 hemopoiesis GO:0033077 T cell differentiation in thymus GO:0035019 somatic stem cell population maintenance GO:0043488 regulation of mRNA stability GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045577 regulation of B cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0048103 somatic stem cell division GO:0060216 definitive hemopoiesis GO:0061158 3'-UTR-mediated mRNA destabilization GO:0070371 ERK1 and ERK2 cascade GO:0071356 cellular response to tumor necrosis factor GO:0071364 cellular response to epidermal growth factor stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071560 cellular response to transforming growth factor beta stimulus GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1901991 negative regulation of mitotic cell cycle phase transition GO:2000737 negative regulation of stem cell differentiation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
