Human Gene ZFP41 (ENST00000330701.7_8) from GENCODE V47lift37
  Description: ZFP41 zinc finger protein, transcript variant 1 (from RefSeq NM_173832.6)
Gencode Transcript: ENST00000330701.7_8
Gencode Gene: ENSG00000181638.20_11
Transcript (Including UTRs)
   Position: hg19 chr8:144,329,109-144,344,875 Size: 15,767 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr8:144,332,014-144,332,610 Size: 597 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:144,329,109-144,344,875)mRNA (may differ from genome)Protein (198 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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-  Comments and Description Text from UniProtKB
  ID: ZFP41_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 41 homolog; Short=Zfp-41;
FUNCTION: A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 4 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.99 RPKM in Testis
Total median expression: 115.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -183.70358-0.513 Picture PostScript Text
3' UTR -1597.303831-0.417 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
55681 - Class II aaRS and biotin synthetases
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q8N8Y5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC034608 - Homo sapiens zinc finger protein 41 homolog (mouse), mRNA (cDNA clone MGC:42732 IMAGE:4827717), complete cds.
AK096024 - Homo sapiens cDNA FLJ38705 fis, clone KIDNE2002725, highly similar to ZINC FINGER PROTEIN 41.
JD483852 - Sequence 464876 from Patent EP1572962.
JD215261 - Sequence 196285 from Patent EP1572962.
JD389847 - Sequence 370871 from Patent EP1572962.
AL831951 - Homo sapiens mRNA; cDNA DKFZp761O1618 (from clone DKFZp761O1618).
JD418700 - Sequence 399724 from Patent EP1572962.
JD456291 - Sequence 437315 from Patent EP1572962.
JD074004 - Sequence 55028 from Patent EP1572962.
KJ900595 - Synthetic construct Homo sapiens clone ccsbBroadEn_09989 ZFP41 gene, encodes complete protein.
JD144093 - Sequence 125117 from Patent EP1572962.
JD307622 - Sequence 288646 from Patent EP1572962.
JD418854 - Sequence 399878 from Patent EP1572962.
JD375682 - Sequence 356706 from Patent EP1572962.
DQ574953 - Homo sapiens piRNA piR-43065, complete sequence.
JD067949 - Sequence 48973 from Patent EP1572962.
JD422400 - Sequence 403424 from Patent EP1572962.
JD219589 - Sequence 200613 from Patent EP1572962.
JD270936 - Sequence 251960 from Patent EP1572962.
JD254393 - Sequence 235417 from Patent EP1572962.
JD213759 - Sequence 194783 from Patent EP1572962.
JD201109 - Sequence 182133 from Patent EP1572962.
JD259291 - Sequence 240315 from Patent EP1572962.
JD230462 - Sequence 211486 from Patent EP1572962.
JD211556 - Sequence 192580 from Patent EP1572962.
JD190716 - Sequence 171740 from Patent EP1572962.
AK021976 - Homo sapiens cDNA FLJ11914 fis, clone HEMBB1000175.
DQ583762 - Homo sapiens piRNA piR-50874, complete sequence.
DQ571006 - Homo sapiens piRNA piR-31118, complete sequence.
AK024438 - Homo sapiens mRNA for FLJ00028 protein, partial cds.
JD515702 - Sequence 496726 from Patent EP1572962.
JD387400 - Sequence 368424 from Patent EP1572962.
JD444327 - Sequence 425351 from Patent EP1572962.
JD555826 - Sequence 536850 from Patent EP1572962.
JD191591 - Sequence 172615 from Patent EP1572962.
JD051050 - Sequence 32074 from Patent EP1572962.
JD134609 - Sequence 115633 from Patent EP1572962.
JD474726 - Sequence 455750 from Patent EP1572962.
JD269084 - Sequence 250108 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DWJ5, ENST00000330701.1, ENST00000330701.2, ENST00000330701.3, ENST00000330701.4, ENST00000330701.5, ENST00000330701.6, NM_173832, Q8N8Y5, uc317tan.1, uc317tan.2, ZFP41_HUMAN
UCSC ID: ENST00000330701.7_8
RefSeq Accession: NM_173832.6
Protein: Q8N8Y5 (aka ZFP41_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.