Human Gene ZFX (ENST00000304543.10_7) from GENCODE V47lift37
  Description: zinc finger protein X-linked, transcript variant 1 (from RefSeq NM_003410.4)
Gencode Transcript: ENST00000304543.10_7
Gencode Gene: ENSG00000005889.16_10
Transcript (Including UTRs)
   Position: hg19 chrX:24,167,846-24,234,372 Size: 66,527 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chrX:24,190,860-24,229,493 Size: 38,634 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:24,167,846-24,234,372)mRNA (may differ from genome)Protein (805 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZFX_HUMAN
DESCRIPTION: RecName: Full=Zinc finger X-chromosomal protein;
FUNCTION: Probable transcriptional activator.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
SIMILARITY: Contains 13 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZFX
Diseases sorted by gene-association score: gallbladder cancer (4), x-linked disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.87 RPKM in Uterus
Total median expression: 207.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.60315-0.288 Picture PostScript Text
3' UTR -1215.304879-0.249 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006794 - Transcrp_activ_Zfx/Zfy-dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF04704 - Zfx / Zfy transcription activation region
PF13894 - C2H2-type zinc finger
PF13909 - C2H2-type zinc-finger domain

SCOP Domains:
54171 - DNA-binding domain
57667 - beta-beta-alpha zinc fingers
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on P17010
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  LF211572 - JP 2014500723-A/19075: Polycomb-Associated Non-Coding RNAs.
AB209892 - Homo sapiens mRNA for X-linked zinc finger protein variant protein.
LP895636 - Sequence 500 from Patent EP3253886.
X59738 - Human ZFX mRNA for put. transcription activator, isoform 1.
LF385335 - JP 2014500723-A/192838: Polycomb-Associated Non-Coding RNAs.
X59740 - Human ZFX mRNA for put. transcription activator, isoform 3.
X59739 - Human ZFX mRNA for put. transcription activator, isoform 2.
JD489720 - Sequence 470744 from Patent EP1572962.
M30608 - Human zinc finger protein X-linked (ZFX) mRNA, complete cds.
JD556769 - Sequence 537793 from Patent EP1572962.
JD255768 - Sequence 236792 from Patent EP1572962.
JD415436 - Sequence 396460 from Patent EP1572962.
BC136308 - Homo sapiens zinc finger protein, X-linked, mRNA (cDNA clone MGC:167918 IMAGE:9020295), complete cds.
BC136309 - Homo sapiens zinc finger protein, X-linked, mRNA (cDNA clone MGC:167919 IMAGE:9020296), complete cds.
JD240376 - Sequence 221400 from Patent EP1572962.
LF381413 - JP 2014500723-A/188916: Polycomb-Associated Non-Coding RNAs.
JD063407 - Sequence 44431 from Patent EP1572962.
AB463353 - Synthetic construct DNA, clone: pF1KB9566, Homo sapiens ZFX gene for X-linked zinc finger protein, without stop codon, in Flexi system.
AF505616 - Homo sapiens X-linked zinc finger protein (ZFX) mRNA, partial cds.
AF505615 - Homo sapiens X-linked zinc finger protein (ZFX) mRNA, partial cds.
AF505618 - Homo sapiens X-linked zinc finger protein (ZFX) mRNA, partial cds.
AF505619 - Homo sapiens X-linked zinc finger protein isoform 5 (ZFX) mRNA, partial cds; alternatively spliced.
KX404987 - Homo sapiens isolate ZFX_exon_inclusion_T7 circular RNA circRNA, complete sequence.
LF381394 - JP 2014500723-A/188897: Polycomb-Associated Non-Coding RNAs.
AF505617 - Homo sapiens X-linked zinc finger protein (ZFX) mRNA, partial cds.
LF381383 - JP 2014500723-A/188886: Polycomb-Associated Non-Coding RNAs.
AF454950 - Homo sapiens X-linked zinc finger protein (ZFX) mRNA, partial cds.
AY072770 - Homo sapiens zinc finger protein ZFX isoform 4 (ZFX) mRNA, partial cds; alternatively spliced.
LF381381 - JP 2014500723-A/188884: Polycomb-Associated Non-Coding RNAs.
LF381380 - JP 2014500723-A/188883: Polycomb-Associated Non-Coding RNAs.
LF381379 - JP 2014500723-A/188882: Polycomb-Associated Non-Coding RNAs.
LF381378 - JP 2014500723-A/188881: Polycomb-Associated Non-Coding RNAs.
LF381377 - JP 2014500723-A/188880: Polycomb-Associated Non-Coding RNAs.
LF381376 - JP 2014500723-A/188879: Polycomb-Associated Non-Coding RNAs.
JD046251 - Sequence 27275 from Patent EP1572962.
JD299607 - Sequence 280631 from Patent EP1572962.
JD550302 - Sequence 531326 from Patent EP1572962.
JD234157 - Sequence 215181 from Patent EP1572962.
JD293257 - Sequence 274281 from Patent EP1572962.
JD270510 - Sequence 251534 from Patent EP1572962.
JD405614 - Sequence 386638 from Patent EP1572962.
JD457393 - Sequence 438417 from Patent EP1572962.
JD457394 - Sequence 438418 from Patent EP1572962.
JD457396 - Sequence 438420 from Patent EP1572962.
JD388805 - Sequence 369829 from Patent EP1572962.
JD388807 - Sequence 369831 from Patent EP1572962.
JD489033 - Sequence 470057 from Patent EP1572962.
JD514195 - Sequence 495219 from Patent EP1572962.
JD514196 - Sequence 495220 from Patent EP1572962.
JD514197 - Sequence 495221 from Patent EP1572962.
JD070733 - Sequence 51757 from Patent EP1572962.
JD070734 - Sequence 51758 from Patent EP1572962.
JD070735 - Sequence 51759 from Patent EP1572962.
BC030756 - Homo sapiens cDNA clone IMAGE:4797449.
LF381375 - JP 2014500723-A/188878: Polycomb-Associated Non-Coding RNAs.
LF381374 - JP 2014500723-A/188877: Polycomb-Associated Non-Coding RNAs.
LF381373 - JP 2014500723-A/188876: Polycomb-Associated Non-Coding RNAs.
MA620912 - JP 2018138019-A/192838: Polycomb-Associated Non-Coding RNAs.
MA447149 - JP 2018138019-A/19075: Polycomb-Associated Non-Coding RNAs.
MA616990 - JP 2018138019-A/188916: Polycomb-Associated Non-Coding RNAs.
MA616971 - JP 2018138019-A/188897: Polycomb-Associated Non-Coding RNAs.
MA616960 - JP 2018138019-A/188886: Polycomb-Associated Non-Coding RNAs.
MA616958 - JP 2018138019-A/188884: Polycomb-Associated Non-Coding RNAs.
MA616957 - JP 2018138019-A/188883: Polycomb-Associated Non-Coding RNAs.
MA616956 - JP 2018138019-A/188882: Polycomb-Associated Non-Coding RNAs.
MA616955 - JP 2018138019-A/188881: Polycomb-Associated Non-Coding RNAs.
MA616954 - JP 2018138019-A/188880: Polycomb-Associated Non-Coding RNAs.
MA616953 - JP 2018138019-A/188879: Polycomb-Associated Non-Coding RNAs.
MA616952 - JP 2018138019-A/188878: Polycomb-Associated Non-Coding RNAs.
MA616951 - JP 2018138019-A/188877: Polycomb-Associated Non-Coding RNAs.
MA616950 - JP 2018138019-A/188876: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B9EG97, ENST00000304543.1, ENST00000304543.2, ENST00000304543.3, ENST00000304543.4, ENST00000304543.5, ENST00000304543.6, ENST00000304543.7, ENST00000304543.8, ENST00000304543.9, NM_003410, O43668, P17010, Q8WYJ8, uc317nlo.1, uc317nlo.2, ZFX_HUMAN
UCSC ID: ENST00000304543.10_7
RefSeq Accession: NM_003410.4
Protein: P17010 (aka ZFX_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.