ID:ZFYV9_HUMAN DESCRIPTION: RecName: Full=Zinc finger FYVE domain-containing protein 9; AltName: Full=Mothers against decapentaplegic homolog-interacting protein; Short=Madh-interacting protein; AltName: Full=Novel serine protease; Short=NSP; AltName: Full=Receptor activation anchor; Short=hSARA; AltName: Full=Smad anchor for receptor activation; FUNCTION: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. SUBUNIT: Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML. INTERACTION: Q9Y561:LRP12; NbExp=2; IntAct=EBI-296817, EBI-296693; P08100:RHO; NbExp=2; IntAct=EBI-296817, EBI-1394177; Q13277:STX3; NbExp=3; IntAct=EBI-296817, EBI-1394295; SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane. TISSUE SPECIFICITY: Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes. DOMAIN: The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3. DOMAIN: The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P. SIMILARITY: Contains 1 FYVE-type zinc finger. SEQUENCE CAUTION: Sequence=AAC99462.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD31694.1; Type=Frameshift; Positions=1243;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95405
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0005545 1-phosphatidylinositol binding GO:0008236 serine-type peptidase activity GO:0019904 protein domain specific binding GO:0046872 metal ion binding
AF130420 - Homo sapiens serine protease-like protein isoform (NSP) mRNA, alternatively spliced, complete cds. AF130419 - Homo sapiens serine protease-like protein isoform (NSP) mRNA, alternatively spliced, complete cds. AF104304 - Homo sapiens Smad anchor for receptor activation (SARA) mRNA, complete cds. JD127676 - Sequence 108700 from Patent EP1572962. JD555439 - Sequence 536463 from Patent EP1572962. BC032680 - Homo sapiens zinc finger, FYVE domain containing 9, mRNA (cDNA clone MGC:45259 IMAGE:5585817), complete cds. CU689478 - Synthetic construct Homo sapiens gateway clone IMAGE:100020565 5' read ZFYVE9 mRNA. EU176568 - Synthetic construct Homo sapiens clone IMAGE:100011385; FLH170642.01L; RZPDo839A12253D zinc finger, FYVE domain containing 9 (ZFYVE9) gene, encodes complete protein. KJ892759 - Synthetic construct Homo sapiens clone ccsbBroadEn_02153 ZFYVE9 gene, encodes complete protein. JD186018 - Sequence 167042 from Patent EP1572962. JD322884 - Sequence 303908 from Patent EP1572962. JD214845 - Sequence 195869 from Patent EP1572962. JD371506 - Sequence 352530 from Patent EP1572962. AB209125 - Homo sapiens mRNA for zinc finger, FYVE domain containing 9 isoform 3 variant protein. AB384409 - Synthetic construct DNA, clone: pF1KSDB3800, Homo sapiens ZFYVE9 gene for zinc finger FYVE domain-containing protein 9, complete cds, without stop codon, in Flexi system. JD530193 - Sequence 511217 from Patent EP1572962. JD292914 - Sequence 273938 from Patent EP1572962. JD326724 - Sequence 307748 from Patent EP1572962. JD303630 - Sequence 284654 from Patent EP1572962. JD040401 - Sequence 21425 from Patent EP1572962. JD040014 - Sequence 21038 from Patent EP1572962. JD083706 - Sequence 64730 from Patent EP1572962. JD349370 - Sequence 330394 from Patent EP1572962. JD277383 - Sequence 258407 from Patent EP1572962. JD053603 - Sequence 34627 from Patent EP1572962. JD425528 - Sequence 406552 from Patent EP1572962. JD351160 - Sequence 332184 from Patent EP1572962. JD351159 - Sequence 332183 from Patent EP1572962. JD364079 - Sequence 345103 from Patent EP1572962. JD362228 - Sequence 343252 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_tgfbPathway - TGF beta signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein O95405 (Reactome details) participates in the following event(s):
R-HSA-170835 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 R-HSA-178189 SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR R-NUL-2167890 Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex R-HSA-3702153 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 MH2 domain mutants R-HSA-3713560 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 phosphorylation motif mutants R-HSA-178178 PP1 dephosphorylates TGFBR1 R-NUL-2167872 PP1CC dephosphorylates TGFBR1 R-HSA-170850 Phosphorylated SMAD2/3 dissociates from TGFBR R-HSA-3702186 Phosphorylated SMAD2/3 MH2 domain mutants dissociate from TGFBR R-HSA-170868 Activated type I receptor phosphorylates SMAD2/3 directly R-HSA-3702184 Activated type I receptor phosphorylates SMAD2/3 MH2 domain mutants directly R-HSA-2173789 TGF-beta receptor signaling activates SMADs R-HSA-2173788 Downregulation of TGF-beta receptor signaling R-HSA-3656532 TGFBR1 KD Mutants in Cancer R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-3656534 Loss of Function of TGFBR1 in Cancer R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer R-HSA-9006936 Signaling by TGF-beta family members R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
