Human Gene ZMAT3 (ENST00000311417.7_11) from GENCODE V47lift37

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Description: zinc finger matrin-type 3, transcript variant 10 (from RefSeq NR_164721.1)
Gencode Transcript: ENST00000311417.7_11
Gencode Gene: ENSG00000172667.11_14
Transcript (Including UTRs)
Position: hg19 chr3:178,735,011-178,789,597 Size: 54,587 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr3:178,742,805-178,785,540 Size: 42,736 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:178,735,011-178,789,597)			mRNA (may differ from genome)		Protein (289 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZMAT3_HUMAN DESCRIPTION: RecName: Full=Zinc finger matrin-type protein 3; AltName: Full=Zinc finger protein WIG-1; AltName: Full=p53-activated gene 608 protein; FUNCTION: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. SUBUNIT: Interacts with dsRNA. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. TISSUE SPECIFICITY: Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine. INDUCTION: By DNA damage in a p53/TP53-dependent manner. Up- regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines. SIMILARITY: Contains 3 matrin-type zinc fingers.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D015073 2-Acetylaminofluorene D000082 Acetaminophen D001564 Benzo(a)pyrene D002945 Cisplatin D008694 Methamphetamine C012277 1,2-diamino-4-nitrobenzene C035314 1-nitropropane C010914 2,4-diaminotoluene C016403 2,4-dinitrotoluene C025235 2,6-diaminotoluene C014706 2-nitro-4-phenylenediamine C019499 2-nitrofluorene C016617 2-nitropropane C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone C028676 4-acetylaminofluorene C027576 4-hydroxy-2-nonenal D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000643 Ammonium Chloride D001554 Benzene D002251 Carbon Tetrachloride D004052 Diethylnitrosamine D004054 Diethylstilbestrol D004128 Dimethylnitrosamine D004317 Doxorubicin D004997 Ethinyl Estradiol D005419 Flavonoids D005472 Fluorouracil C500810 GW8510 D008701 Methapyrilene D008748 Methylcholanthrene D010634 Phenobarbital D010882 Piperonyl Butoxide D010894 Piroxicam D011285 Pregnenolone Carbonitrile D011794 Quercetin D012822 Silicon Dioxide D013749 Tetrachlorodibenzodioxin D014415 Tunicamycin D014635 Valproic Acid C053541 bicalutamide C018021 cobaltous chloride C024352 fludarabine C045463 leflunomide C014707 nitrosobenzylmethylamine C482205 nutlin 3 C025589 ochratoxin A C027579 periodate-oxidized adenosine C006253 pirinixic acid C010327 salinomycin C402769 tipifarnib C009495 titanium dioxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 23.02 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 229.47 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-130.20	272	-0.479	Picture	PostScript	Text
3' UTR	-1945.40	7794	-0.250	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR015880 - Znf_C2H2-like
IPR022755 - Znf_C2H2_jaz
IPR003604 - Znf_U1

Pfam Domains:
PF12171 - Zinc-finger double-stranded RNA-binding
PF12874 - Zinc-finger of C2H2 type

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
82919 - Zn-finger domain of Sec23/24
57845 - B-box zinc-binding domain

ModBase Predicted Comparative 3D Structure on Q9HA38


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0002039 p53 binding GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0046872 metal ion binding Biological Process: GO:0006915 apoptotic process GO:0006974 cellular response to DNA damage stimulus GO:0015031 protein transport GO:0040008 regulation of growth GO:0043065 positive regulation of apoptotic process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005730 nucleolus GO:0005886 plasma membrane

Descriptions from all associated GenBank mRNAs


	BC002896 - Homo sapiens zinc finger, matrin type 3, mRNA (cDNA clone MGC:10613 IMAGE:3943641), complete cds. AK122768 - Homo sapiens cDNA FLJ16307 fis, clone PUAEN2004875, highly similar to Homo sapiens p53 target zinc finger protein (WIG1), transcript variant 2, mRNA. AK022358 - Homo sapiens cDNA FLJ12296 fis, clone MAMMA1001820, moderately similar to Rattus norvegicus mRNA for PAG608 gene. AF355465 - Homo sapiens WIG-1/PAG608 protein mRNA, complete cds. AY037945 - Homo sapiens zinc finger protein WIG1 mRNA, complete cds. HQ447424 - Synthetic construct Homo sapiens clone IMAGE:100070747; CCSB004413_02 zinc finger, matrin type 3 (ZMAT3) gene, encodes complete protein. KJ894548 - Synthetic construct Homo sapiens clone ccsbBroadEn_03942 ZMAT3 gene, encodes complete protein. CU678276 - Synthetic construct Homo sapiens gateway clone IMAGE:100018749 5' read ZMAT3 mRNA. BC036485 - Homo sapiens cDNA clone IMAGE:5261213. AK056245 - Homo sapiens cDNA FLJ31683 fis, clone NT2RI2005353. JD411926 - Sequence 392950 from Patent EP1572962. JD417681 - Sequence 398705 from Patent EP1572962. JD376752 - Sequence 357776 from Patent EP1572962. JD522516 - Sequence 503540 from Patent EP1572962. JD561332 - Sequence 542356 from Patent EP1572962. JD179675 - Sequence 160699 from Patent EP1572962. JD481334 - Sequence 462358 from Patent EP1572962. JD310174 - Sequence 291198 from Patent EP1572962. JD557771 - Sequence 538795 from Patent EP1572962. JD261691 - Sequence 242715 from Patent EP1572962. JD301344 - Sequence 282368 from Patent EP1572962. JD315366 - Sequence 296390 from Patent EP1572962. JD301345 - Sequence 282369 from Patent EP1572962. JD261896 - Sequence 242920 from Patent EP1572962. JD224403 - Sequence 205427 from Patent EP1572962. JD051810 - Sequence 32834 from Patent EP1572962. JD239269 - Sequence 220293 from Patent EP1572962. JD562399 - Sequence 543423 from Patent EP1572962. JD433192 - Sequence 414216 from Patent EP1572962. JD248963 - Sequence 229987 from Patent EP1572962. LF211889 - JP 2014500723-A/19392: Polycomb-Associated Non-Coding RNAs. JD271687 - Sequence 252711 from Patent EP1572962. MA447466 - JP 2018138019-A/19392: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B3KVA6, D3DNR1, ENST00000311417.1, ENST00000311417.2, ENST00000311417.3, ENST00000311417.4, ENST00000311417.5, ENST00000311417.6, NR_164721, PAG608 , Q96A21, Q9HA38, uc317ozn.1, uc317ozn.2, WIG1 , ZMAT3 , ZMAT3_HUMAN UCSC ID: ENST00000311417.7_11 RefSeq Accession: NM_022470.4 Protein: Q9HA38 (aka ZMAT3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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