Human Gene ZMIZ1 (ENST00000334512.10_4) from GENCODE V47lift37
  Description: zinc finger MIZ-type containing 1 (from RefSeq NM_020338.4)
Gencode Transcript: ENST00000334512.10_4
Gencode Gene: ENSG00000108175.19_9
Transcript (Including UTRs)
   Position: hg19 chr10:80,828,723-81,076,276 Size: 247,554 Total Exon Count: 25 Strand: +
Coding Region
   Position: hg19 chr10:80,961,390-81,072,506 Size: 111,117 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:80,828,723-81,076,276)mRNA (may differ from genome)Protein (1067 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZMIZ1_HUMAN
DESCRIPTION: RecName: Full=Zinc finger MIZ domain-containing protein 1; AltName: Full=PIAS-like protein Zimp10; AltName: Full=Retinoic acid-induced protein 17;
FUNCTION: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.
SUBUNIT: Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.
SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm.
TISSUE SPECIFICITY: Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
DOMAIN: The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.
SIMILARITY: Contains 1 SP-RING-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.91 RPKM in Cervix - Endocervix
Total median expression: 744.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -300.90641-0.469 Picture PostScript Text
3' UTR -1324.003770-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004181 - Znf_MIZ
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF02891 - MIZ/SP-RING zinc finger
PF18028 - Zmiz1 N-terminal tetratricopeptide repeat domain

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q9ULJ6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0003007 heart morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007296 vitellogenesis
GO:0007569 cell aging
GO:0045582 positive regulation of T cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048589 developmental growth
GO:0048844 artery morphogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC007288 - Homo sapiens zinc finger, MIZ-type containing 1, mRNA (cDNA clone IMAGE:3347864), partial cds.
AY235683 - Homo sapiens PIAS-like protein hZimp10 mRNA, complete cds.
BC117687 - Homo sapiens zinc finger, MIZ-type containing 1, mRNA (cDNA clone IMAGE:40071403), complete cds.
BC172361 - Synthetic construct Homo sapiens clone IMAGE:100069055, MGC:199066 zinc finger, MIZ-type containing 1 (ZMIZ1) mRNA, encodes complete protein.
JD395727 - Sequence 376751 from Patent EP1572962.
JD184393 - Sequence 165417 from Patent EP1572962.
JD058956 - Sequence 39980 from Patent EP1572962.
JD145273 - Sequence 126297 from Patent EP1572962.
JD057434 - Sequence 38458 from Patent EP1572962.
JD532012 - Sequence 513036 from Patent EP1572962.
JD068583 - Sequence 49607 from Patent EP1572962.
AK025812 - Homo sapiens cDNA: FLJ22159 fis, clone HRC00251.
JD309718 - Sequence 290742 from Patent EP1572962.
JD452865 - Sequence 433889 from Patent EP1572962.
JD540695 - Sequence 521719 from Patent EP1572962.
AB033050 - Homo sapiens mRNA for KIAA1224 protein, partial cds.
AK024490 - Homo sapiens mRNA for FLJ00092 protein, partial cds.
AF357909 - Homo sapiens TRAFIP10 (TRAFIP10) mRNA, complete cds.
AK299728 - Homo sapiens cDNA FLJ57189 complete cds, highly similar to Retinoic acid-induced protein 17.
BC025342 - Homo sapiens cDNA clone IMAGE:3622865, partial cds.
BC068072 - Homo sapiens zinc finger, MIZ-type containing 1, mRNA (cDNA clone IMAGE:3623644), **** WARNING: chimeric clone ****.
BC035890 - Homo sapiens, clone IMAGE:5192508, mRNA.
BC049845 - Homo sapiens retinoic acid induced 17, mRNA (cDNA clone IMAGE:5191750), partial cds.
JD228711 - Sequence 209735 from Patent EP1572962.
JD215900 - Sequence 196924 from Patent EP1572962.
JD056015 - Sequence 37039 from Patent EP1572962.
JD386319 - Sequence 367343 from Patent EP1572962.
JD164494 - Sequence 145518 from Patent EP1572962.
JD289649 - Sequence 270673 from Patent EP1572962.
JD205450 - Sequence 186474 from Patent EP1572962.
JD303361 - Sequence 284385 from Patent EP1572962.
JD215442 - Sequence 196466 from Patent EP1572962.
JD214494 - Sequence 195518 from Patent EP1572962.
JD064174 - Sequence 45198 from Patent EP1572962.
JD470801 - Sequence 451825 from Patent EP1572962.
JD164462 - Sequence 145486 from Patent EP1572962.
JD551392 - Sequence 532416 from Patent EP1572962.
JD243326 - Sequence 224350 from Patent EP1572962.
JD519495 - Sequence 500519 from Patent EP1572962.
JD449744 - Sequence 430768 from Patent EP1572962.
JD343662 - Sequence 324686 from Patent EP1572962.
JD483458 - Sequence 464482 from Patent EP1572962.
JD103958 - Sequence 84982 from Patent EP1572962.
JD314128 - Sequence 295152 from Patent EP1572962.
JD338745 - Sequence 319769 from Patent EP1572962.
JD191075 - Sequence 172099 from Patent EP1572962.
JD479635 - Sequence 460659 from Patent EP1572962.
JD199981 - Sequence 181005 from Patent EP1572962.
JD281789 - Sequence 262813 from Patent EP1572962.
AL049432 - Homo sapiens mRNA; cDNA DKFZp586J231 (from clone DKFZp586J231).
JD271195 - Sequence 252219 from Patent EP1572962.
JD543726 - Sequence 524750 from Patent EP1572962.
JD069488 - Sequence 50512 from Patent EP1572962.
JD055753 - Sequence 36777 from Patent EP1572962.
JD534911 - Sequence 515935 from Patent EP1572962.
JD255287 - Sequence 236311 from Patent EP1572962.
AK023603 - Homo sapiens cDNA FLJ13541 fis, clone PLACE1006760.
JD102170 - Sequence 83194 from Patent EP1572962.
JD162394 - Sequence 143418 from Patent EP1572962.
JD086631 - Sequence 67655 from Patent EP1572962.
JD395226 - Sequence 376250 from Patent EP1572962.
JD407853 - Sequence 388877 from Patent EP1572962.
JD520488 - Sequence 501512 from Patent EP1572962.
JD387804 - Sequence 368828 from Patent EP1572962.
JD150650 - Sequence 131674 from Patent EP1572962.
JD387871 - Sequence 368895 from Patent EP1572962.
JD293605 - Sequence 274629 from Patent EP1572962.
JD036572 - Sequence 17596 from Patent EP1572962.
JD219868 - Sequence 200892 from Patent EP1572962.
JD507440 - Sequence 488464 from Patent EP1572962.
JD131898 - Sequence 112922 from Patent EP1572962.
JD209167 - Sequence 190191 from Patent EP1572962.
JD457740 - Sequence 438764 from Patent EP1572962.
JD385328 - Sequence 366352 from Patent EP1572962.
JD158483 - Sequence 139507 from Patent EP1572962.
JD429950 - Sequence 410974 from Patent EP1572962.
JD559089 - Sequence 540113 from Patent EP1572962.
JD376888 - Sequence 357912 from Patent EP1572962.
JD297941 - Sequence 278965 from Patent EP1572962.
JD369851 - Sequence 350875 from Patent EP1572962.
JD277166 - Sequence 258190 from Patent EP1572962.
AF070622 - Homo sapiens clone 24800 mRNA sequence.
JD318557 - Sequence 299581 from Patent EP1572962.
JD036450 - Sequence 17474 from Patent EP1572962.
JD260602 - Sequence 241626 from Patent EP1572962.
JD299963 - Sequence 280987 from Patent EP1572962.
JD325069 - Sequence 306093 from Patent EP1572962.
JD343720 - Sequence 324744 from Patent EP1572962.
JD564137 - Sequence 545161 from Patent EP1572962.
JD447906 - Sequence 428930 from Patent EP1572962.
JD416217 - Sequence 397241 from Patent EP1572962.
JD257140 - Sequence 238164 from Patent EP1572962.
JD143630 - Sequence 124654 from Patent EP1572962.
JD088600 - Sequence 69624 from Patent EP1572962.
JD183470 - Sequence 164494 from Patent EP1572962.
JD187299 - Sequence 168323 from Patent EP1572962.
JD268718 - Sequence 249742 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000334512.1, ENST00000334512.2, ENST00000334512.3, ENST00000334512.4, ENST00000334512.5, ENST00000334512.6, ENST00000334512.7, ENST00000334512.8, ENST00000334512.9, KIAA1224, NM_020338, Q5JSH9, Q7Z7E6, Q9ULJ6, RAI17, uc317tzk.1, uc317tzk.2, ZIMP10, ZMIZ1 , ZMIZ1_HUMAN
UCSC ID: ENST00000334512.10_4
RefSeq Accession: NM_020338.4
Protein: Q9ULJ6 (aka ZMIZ1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.