Human Gene ZNF100 (ENST00000358296.11_10) from GENCODE V47lift37
  Description: zinc finger protein 100, transcript variant 1 (from RefSeq NM_173531.4)
Gencode Transcript: ENST00000358296.11_10
Gencode Gene: ENSG00000197020.12_17
Transcript (Including UTRs)
   Position: hg19 chr19:21,905,573-21,950,381 Size: 44,809 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:21,909,485-21,950,231 Size: 40,747 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:21,905,573-21,950,381)mRNA (may differ from genome)Protein (542 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN100_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 100;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 12 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.90 RPKM in Testis
Total median expression: 62.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.30150-0.309 Picture PostScript Text
3' UTR -884.803912-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
82919 - Zn-finger domain of Sec23/24
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q8IYN0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  JD301472 - Sequence 282496 from Patent EP1572962.
JD110189 - Sequence 91213 from Patent EP1572962.
JD082742 - Sequence 63766 from Patent EP1572962.
JD110023 - Sequence 91047 from Patent EP1572962.
JD091487 - Sequence 72511 from Patent EP1572962.
JD415029 - Sequence 396053 from Patent EP1572962.
JD397154 - Sequence 378178 from Patent EP1572962.
JD069796 - Sequence 50820 from Patent EP1572962.
JD094159 - Sequence 75183 from Patent EP1572962.
JD256592 - Sequence 237616 from Patent EP1572962.
JD476818 - Sequence 457842 from Patent EP1572962.
JD513972 - Sequence 494996 from Patent EP1572962.
JD120610 - Sequence 101634 from Patent EP1572962.
JD379779 - Sequence 360803 from Patent EP1572962.
JD536578 - Sequence 517602 from Patent EP1572962.
JD342492 - Sequence 323516 from Patent EP1572962.
JD209742 - Sequence 190766 from Patent EP1572962.
JD270144 - Sequence 251168 from Patent EP1572962.
JD405467 - Sequence 386491 from Patent EP1572962.
JD239653 - Sequence 220677 from Patent EP1572962.
JD365192 - Sequence 346216 from Patent EP1572962.
JD330942 - Sequence 311966 from Patent EP1572962.
JD295424 - Sequence 276448 from Patent EP1572962.
JD384748 - Sequence 365772 from Patent EP1572962.
JD384747 - Sequence 365771 from Patent EP1572962.
JD489032 - Sequence 470056 from Patent EP1572962.
JD489031 - Sequence 470055 from Patent EP1572962.
JD374507 - Sequence 355531 from Patent EP1572962.
JD322279 - Sequence 303303 from Patent EP1572962.
JD367511 - Sequence 348535 from Patent EP1572962.
JD213143 - Sequence 194167 from Patent EP1572962.
JD217961 - Sequence 198985 from Patent EP1572962.
JD278413 - Sequence 259437 from Patent EP1572962.
JD498555 - Sequence 479579 from Patent EP1572962.
JD283034 - Sequence 264058 from Patent EP1572962.
JD090564 - Sequence 71588 from Patent EP1572962.
JD361620 - Sequence 342644 from Patent EP1572962.
JD428570 - Sequence 409594 from Patent EP1572962.
JD553459 - Sequence 534483 from Patent EP1572962.
JD314755 - Sequence 295779 from Patent EP1572962.
JD554211 - Sequence 535235 from Patent EP1572962.
JD349575 - Sequence 330599 from Patent EP1572962.
JD177878 - Sequence 158902 from Patent EP1572962.
BX640982 - Homo sapiens mRNA; cDNA DKFZp686M04222 (from clone DKFZp686M04222).
JD552720 - Sequence 533744 from Patent EP1572962.
JD155426 - Sequence 136450 from Patent EP1572962.
JD237687 - Sequence 218711 from Patent EP1572962.
JD524004 - Sequence 505028 from Patent EP1572962.
JD256918 - Sequence 237942 from Patent EP1572962.
JD137197 - Sequence 118221 from Patent EP1572962.
JD325194 - Sequence 306218 from Patent EP1572962.
JD308171 - Sequence 289195 from Patent EP1572962.
JD310953 - Sequence 291977 from Patent EP1572962.
JD552330 - Sequence 533354 from Patent EP1572962.
JD426779 - Sequence 407803 from Patent EP1572962.
JD255998 - Sequence 237022 from Patent EP1572962.
JD321755 - Sequence 302779 from Patent EP1572962.
JD531338 - Sequence 512362 from Patent EP1572962.
JD296699 - Sequence 277723 from Patent EP1572962.
JD240702 - Sequence 221726 from Patent EP1572962.
JD299682 - Sequence 280706 from Patent EP1572962.
JD512321 - Sequence 493345 from Patent EP1572962.
JD037249 - Sequence 18273 from Patent EP1572962.
AK126551 - Homo sapiens cDNA FLJ44587 fis, clone ASTRO2016114, moderately similar to Zinc finger protein 85.
JD530273 - Sequence 511297 from Patent EP1572962.
BC031248 - Homo sapiens zinc finger protein 100, mRNA (cDNA clone IMAGE:5268612), partial cds.
JD052791 - Sequence 33815 from Patent EP1572962.
JD083600 - Sequence 64624 from Patent EP1572962.
JD313416 - Sequence 294440 from Patent EP1572962.
JD225679 - Sequence 206703 from Patent EP1572962.
JD314370 - Sequence 295394 from Patent EP1572962.
JD330508 - Sequence 311532 from Patent EP1572962.
KJ905632 - Synthetic construct Homo sapiens clone ccsbBroadEn_15273 ZNF100 gene, encodes complete protein.
JD314376 - Sequence 295400 from Patent EP1572962.
JD066994 - Sequence 48018 from Patent EP1572962.
JD330516 - Sequence 311540 from Patent EP1572962.
JD330513 - Sequence 311537 from Patent EP1572962.
JD330514 - Sequence 311538 from Patent EP1572962.
JD330515 - Sequence 311539 from Patent EP1572962.
CU690114 - Synthetic construct Homo sapiens gateway clone IMAGE:100019825 5' read ZNF100 mRNA.
AK308798 - Homo sapiens cDNA, FLJ98839.
JD328851 - Sequence 309875 from Patent EP1572962.
JD259380 - Sequence 240404 from Patent EP1572962.
JD259381 - Sequence 240405 from Patent EP1572962.
JD259382 - Sequence 240406 from Patent EP1572962.
BC035579 - Homo sapiens zinc finger protein 100, mRNA (cDNA clone MGC:45410 IMAGE:5576923), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IYN0 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000358296.1, ENST00000358296.10, ENST00000358296.2, ENST00000358296.3, ENST00000358296.4, ENST00000358296.5, ENST00000358296.6, ENST00000358296.7, ENST00000358296.8, ENST00000358296.9, NM_173531, Q7M4M0, Q8IYN0, uc318amb.1, uc318amb.2, ZN100_HUMAN
UCSC ID: ENST00000358296.11_10
RefSeq Accession: NM_173531.4
Protein: Q8IYN0 (aka ZN100_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.