Human Gene ZNF19 (ENST00000288177.10_7) from GENCODE V47lift37
  Description: zinc finger protein 19 (from RefSeq NM_006961.4)
Gencode Transcript: ENST00000288177.10_7
Gencode Gene: ENSG00000157429.16_15
Transcript (Including UTRs)
   Position: hg19 chr16:71,507,486-71,523,227 Size: 15,742 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr16:71,509,073-71,516,017 Size: 6,945 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:71,507,486-71,523,227)mRNA (may differ from genome)Protein (458 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNF19_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 19; AltName: Full=Zinc finger protein KOX12;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 10 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=AAA36814.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.41 RPKM in Testis
Total median expression: 30.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.80242-0.359 Picture PostScript Text
3' UTR -457.601587-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
55550 - SH2 domain
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on P17023
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC030658 - Homo sapiens cDNA clone IMAGE:4837152, **** WARNING: chimeric clone ****.
AY500362 - Homo sapiens zinc finger protein 36 (HZF36) mRNA, partial cds.
JD443416 - Sequence 424440 from Patent EP1572962.
JD410133 - Sequence 391157 from Patent EP1572962.
JD411979 - Sequence 393003 from Patent EP1572962.
JD417707 - Sequence 398731 from Patent EP1572962.
JD417708 - Sequence 398732 from Patent EP1572962.
JD376774 - Sequence 357798 from Patent EP1572962.
JD548128 - Sequence 529152 from Patent EP1572962.
AL834237 - Homo sapiens mRNA; cDNA DKFZp547H042 (from clone DKFZp547H042).
AK057330 - Homo sapiens cDNA FLJ32768 fis, clone TESTI2001879, weakly similar to ZINC FINGER PROTEIN 157.
JD364456 - Sequence 345480 from Patent EP1572962.
JD344526 - Sequence 325550 from Patent EP1572962.
JD557749 - Sequence 538773 from Patent EP1572962.
JD235847 - Sequence 216871 from Patent EP1572962.
BC047091 - Homo sapiens zinc finger protein 19, mRNA (cDNA clone MGC:51021 IMAGE:5270853), complete cds.
AK055567 - Homo sapiens cDNA FLJ31005 fis, clone HLUNG2000068, weakly similar to ZINC FINGER PROTEIN 157.
JD023001 - Sequence 4025 from Patent EP1572962.
JD027722 - Sequence 8746 from Patent EP1572962.
AK292260 - Homo sapiens cDNA FLJ77592 complete cds, highly similar to Homo sapiens zinc finger protein 19, mRNA.
JD063494 - Sequence 44518 from Patent EP1572962.
JD440971 - Sequence 421995 from Patent EP1572962.
JD145604 - Sequence 126628 from Patent EP1572962.
JD086099 - Sequence 67123 from Patent EP1572962.
JD155133 - Sequence 136157 from Patent EP1572962.
JD224733 - Sequence 205757 from Patent EP1572962.
JD051530 - Sequence 32554 from Patent EP1572962.
HQ448475 - Synthetic construct Homo sapiens clone IMAGE:100071906; CCSB010699_01 zinc finger protein 19 (ZNF19) gene, encodes complete protein.
KJ897758 - Synthetic construct Homo sapiens clone ccsbBroadEn_07152 ZNF19 gene, encodes complete protein.
AB528051 - Synthetic construct DNA, clone: pF1KB7787, Homo sapiens ZNF19 gene for zinc finger protein 19, without stop codon, in Flexi system.
JD047452 - Sequence 28476 from Patent EP1572962.
CU690372 - Synthetic construct Homo sapiens gateway clone IMAGE:100020905 5' read ZNF19 mRNA.
X52343 - Human Kox12 mRNA for zinc finger protein, partial.
AK311003 - Homo sapiens cDNA, FLJ18045.
JD399990 - Sequence 381014 from Patent EP1572962.
JD507376 - Sequence 488400 from Patent EP1572962.
JD318857 - Sequence 299881 from Patent EP1572962.
JD416443 - Sequence 397467 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P17023 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K895, ENST00000288177.1, ENST00000288177.2, ENST00000288177.3, ENST00000288177.4, ENST00000288177.5, ENST00000288177.6, ENST00000288177.7, ENST00000288177.8, ENST00000288177.9, KOX12, NM_006961, P17023, Q86Y66, Q8NDE2, Q96M79, Q96NE5, uc317kpe.1, uc317kpe.2, ZNF19_HUMAN
UCSC ID: ENST00000288177.10_7
RefSeq Accession: NM_006961.4
Protein: P17023 (aka ZNF19_HUMAN or ZN19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.