Human Gene ZNF22 (ENST00000298299.4_4) from GENCODE V47lift37
  Description: zinc finger protein 22 (from RefSeq NM_006963.5)
Gencode Transcript: ENST00000298299.4_4
Gencode Gene: ENSG00000165512.5_7
Transcript (Including UTRs)
   Position: hg19 chr10:45,496,371-45,500,774 Size: 4,404 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr10:45,498,817-45,499,491 Size: 675 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:45,496,371-45,500,774)mRNA (may differ from genome)Protein (224 aa)
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-  Comments and Description Text from UniProtKB
  ID: ZNF22_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 22; AltName: Full=Zinc finger protein KOX15; AltName: Full=Zinc finger protein Krox-26;
FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF22
Diseases sorted by gene-association score: tooth agenesis (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.79 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 605.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.50145-0.307 Picture PostScript Text
3' UTR -266.301283-0.208 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
55550 - SH2 domain
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on P17026
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0042476 odontogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  HQ447131 - Synthetic construct Homo sapiens clone IMAGE:100070419; CCSB002959_02 zinc finger protein 22 (KOX 15) (ZNF22) gene, encodes complete protein.
KJ892401 - Synthetic construct Homo sapiens clone ccsbBroadEn_01795 ZNF22 gene, encodes complete protein.
BC041139 - Homo sapiens zinc finger protein 22 (KOX 15), mRNA (cDNA clone MGC:47687 IMAGE:5751460), complete cds.
AK312278 - Homo sapiens cDNA, FLJ92577.
AK291508 - Homo sapiens cDNA FLJ75698 complete cds, highly similar to Homo sapiens zinc finger protein 22 (KOX 15) (ZNF22), mRNA.
BC053687 - Homo sapiens zinc finger protein 22 (KOX 15), mRNA (cDNA clone MGC:61583 IMAGE:5214077), complete cds.
BC010642 - Homo sapiens zinc finger protein 22 (KOX 15), mRNA (cDNA clone MGC:9735 IMAGE:3852749), complete cds.
S50223 - HKR-T1=Kruppel-like zinc finger protein [human, MOLT 4 T-cells, mRNA, 798 nt].
JD153758 - Sequence 134782 from Patent EP1572962.
AB464754 - Synthetic construct DNA, clone: pF1KB9663, Homo sapiens ZNF22 gene for zinc finger protein 22, without stop codon, in Flexi system.
CU679775 - Synthetic construct Homo sapiens gateway clone IMAGE:100016809 5' read ZNF22 mRNA.
BT009806 - Homo sapiens zinc finger protein 22 (KOX 15) mRNA, complete cds.
JD314875 - Sequence 295899 from Patent EP1572962.
X52346 - Human Kox15 mRNA for zinc finger protein, partial.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000298299.1, ENST00000298299.2, ENST00000298299.3, KOX15, KROX26, NM_006963, P17026, Q5T741, Q96FM4, uc317mea.1, uc317mea.2, ZNF22_HUMAN
UCSC ID: ENST00000298299.4_4
RefSeq Accession: NM_006963.5
Protein: P17026 (aka ZNF22_HUMAN or ZN22_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.