ID:ZN224_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 224; AltName: Full=Bone marrow zinc finger 2; Short=BMZF-2; AltName: Full=Zinc finger protein 233; AltName: Full=Zinc finger protein 255; AltName: Full=Zinc finger protein 27; AltName: Full=Zinc finger protein KOX22; FUNCTION: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. SUBUNIT: Interacts with WT1. Interacts with DEPDC1A. SUBCELLULAR LOCATION: Nucleus. Note=Co-localizes with DEPDC1A at the nucleus. TISSUE SPECIFICITY: Ubiquitous. Mainly expressed in fetal tissues. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 18 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZL3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045892 negative regulation of transcription, DNA-templated
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
