Human Gene ZNF280A (ENST00000302097.3_7) from GENCODE V47lift37
  Description: zinc finger protein 280A (from RefSeq NM_080740.5)
Gencode Transcript: ENST00000302097.3_7
Gencode Gene: ENSG00000169548.3_10
Transcript (Including UTRs)
   Position: hg19 chr22:22,868,060-22,874,613 Size: 6,554 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr22:22,868,326-22,869,954 Size: 1,629 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:22,868,060-22,874,613)mRNA (may differ from genome)Protein (532 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Z280A_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 280A; AltName: Full=3'OY11.1; AltName: Full=Suppressor of hairy wing homolog 1; AltName: Full=Zinc finger protein 636;
FUNCTION: May function as a transcription factor.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 4 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.05 RPKM in Adrenal Gland
Total median expression: 1.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.40252-0.291 Picture PostScript Text
3' UTR -59.40265-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025243 - DUF4195
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF13836 - Domain of unknown function (DUF4195)

ModBase Predicted Comparative 3D Structure on P59817
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC053901 - Homo sapiens zinc finger protein 280A, mRNA (cDNA clone MGC:61573 IMAGE:6166804), complete cds.
AK093108 - Homo sapiens cDNA FLJ35789 fis, clone TESTI2005703, highly similar to Suppressor of hairy wing homolog 1.
HQ258003 - Synthetic construct Homo sapiens clone IMAGE:100072312 zinc finger protein 280A (ZNF280A) gene, encodes complete protein.
KJ900125 - Synthetic construct Homo sapiens clone ccsbBroadEn_09519 ZNF280A gene, encodes complete protein.
AB489187 - Synthetic construct DNA, clone: pF1KB9876, Homo sapiens ZNF280A gene for zinc finger protein 280A, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000302097.1, ENST00000302097.2, NM_080740, P59817, SUHW1, uc317myp.1, uc317myp.2, Z280A_HUMAN, ZNF280, ZNF636
UCSC ID: ENST00000302097.3_7
RefSeq Accession: NM_080740.5
Protein: P59817 (aka Z280A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.