Human Gene ZNF280D (ENST00000267807.12_12) from GENCODE V47lift37
  Description: zinc finger protein 280D, transcript variant 1 (from RefSeq NM_017661.4)
Gencode Transcript: ENST00000267807.12_12
Gencode Gene: ENSG00000137871.21_15
Transcript (Including UTRs)
   Position: hg19 chr15:56,922,374-57,025,707 Size: 103,334 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr15:56,923,696-56,999,307 Size: 75,612 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:56,922,374-57,025,707)mRNA (may differ from genome)Protein (979 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Z280D_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 280D; AltName: Full=Suppressor of hairy wing homolog 4; AltName: Full=Zinc finger protein 634;
FUNCTION: May function as a transcription factor.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAB13410.1; Type=Erroneous initiation; Sequence=CAE46003.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF280D
Diseases sorted by gene-association score: reading disorder (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.38 RPKM in Cervix - Endocervix
Total median expression: 158.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.50137-0.288 Picture PostScript Text
3' UTR -284.001322-0.215 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025243 - DUF4195
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF13836 - Domain of unknown function (DUF4195)
PF13912 - C2H2-type zinc finger

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q6N043
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF208550 - JP 2014500723-A/16053: Polycomb-Associated Non-Coding RNAs.
BC040532 - Homo sapiens zinc finger protein 280D, mRNA (cDNA clone IMAGE:5261474).
BX641000 - Homo sapiens mRNA; cDNA DKFZp686H13148 (from clone DKFZp686H13148); complete cds.
AB046804 - Homo sapiens KIAA1584 mRNA for KIAA1584 protein.
BC130451 - Homo sapiens zinc finger protein 280D, mRNA (cDNA clone MGC:163323 IMAGE:40146482), complete cds.
BC136412 - Homo sapiens zinc finger protein 280D, mRNA (cDNA clone MGC:168023 IMAGE:9020400), complete cds.
BX640707 - Homo sapiens mRNA; cDNA DKFZp686F11161 (from clone DKFZp686F11161); complete cds.
AK295159 - Homo sapiens cDNA FLJ56078 complete cds, highly similar to Suppressor of hairy wing homolog 4.
AK289739 - Homo sapiens cDNA FLJ76213 complete cds, highly similar to Homo sapiens suppressor of hairy wing homolog 4 (Drosophila) (SUHW4), transcript variant 2, mRNA.
AM392650 - Synthetic construct Homo sapiens clone IMAGE:100002534 for hypothetical protein (SUHW4 gene).
AM393745 - Synthetic construct Homo sapiens clone IMAGE:100002533 for hypothetical protein (SUHW4 gene).
BX640637 - Homo sapiens mRNA; cDNA DKFZp779P138 (from clone DKFZp779P138); complete cds.
BC036541 - Homo sapiens cDNA clone IMAGE:4829311.
AK310882 - Homo sapiens cDNA, FLJ17924.
BC064359 - Homo sapiens zinc finger protein 280D, mRNA (cDNA clone IMAGE:5531919), complete cds.
BC053649 - Homo sapiens zinc finger protein 280D, mRNA (cDNA clone IMAGE:5538785), complete cds.
MA444127 - JP 2018138019-A/16053: Polycomb-Associated Non-Coding RNAs.
LF377638 - JP 2014500723-A/185141: Polycomb-Associated Non-Coding RNAs.
AL136634 - Homo sapiens mRNA; cDNA DKFZp564H102 (from clone DKFZp564H102); complete cds.
AK000093 - Homo sapiens cDNA FLJ20086 fis, clone COL03629.
JD160480 - Sequence 141504 from Patent EP1572962.
JD506801 - Sequence 487825 from Patent EP1572962.
LF377637 - JP 2014500723-A/185140: Polycomb-Associated Non-Coding RNAs.
JD347838 - Sequence 328862 from Patent EP1572962.
JD509098 - Sequence 490122 from Patent EP1572962.
JD285954 - Sequence 266978 from Patent EP1572962.
AB385484 - Synthetic construct DNA, clone: pF1KA1584, Homo sapiens SUHW4 gene for suppressor of hairy wing homolog 4, complete cds, without stop codon, in Flexi system.
LF377636 - JP 2014500723-A/185139: Polycomb-Associated Non-Coding RNAs.
LF377635 - JP 2014500723-A/185138: Polycomb-Associated Non-Coding RNAs.
JD378852 - Sequence 359876 from Patent EP1572962.
LF377634 - JP 2014500723-A/185137: Polycomb-Associated Non-Coding RNAs.
JD073517 - Sequence 54541 from Patent EP1572962.
JD049286 - Sequence 30310 from Patent EP1572962.
JD357787 - Sequence 338811 from Patent EP1572962.
AK025073 - Homo sapiens cDNA: FLJ21420 fis, clone COL04105.
LF377622 - JP 2014500723-A/185125: Polycomb-Associated Non-Coding RNAs.
JD082130 - Sequence 63154 from Patent EP1572962.
BC015382 - Homo sapiens zinc finger protein 280D, mRNA (cDNA clone IMAGE:4413086), complete cds.
LF377617 - JP 2014500723-A/185120: Polycomb-Associated Non-Coding RNAs.
MA613215 - JP 2018138019-A/185141: Polycomb-Associated Non-Coding RNAs.
MA613214 - JP 2018138019-A/185140: Polycomb-Associated Non-Coding RNAs.
MA613213 - JP 2018138019-A/185139: Polycomb-Associated Non-Coding RNAs.
MA613212 - JP 2018138019-A/185138: Polycomb-Associated Non-Coding RNAs.
MA613211 - JP 2018138019-A/185137: Polycomb-Associated Non-Coding RNAs.
MA613199 - JP 2018138019-A/185125: Polycomb-Associated Non-Coding RNAs.
MA613194 - JP 2018138019-A/185120: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A1L495, B2RMT6, ENST00000267807.1, ENST00000267807.10, ENST00000267807.11, ENST00000267807.2, ENST00000267807.3, ENST00000267807.4, ENST00000267807.5, ENST00000267807.6, ENST00000267807.7, ENST00000267807.8, ENST00000267807.9, KIAA1584, NM_017661, Q6MZM6, Q6N043, Q6N085, Q6P2R6, Q7Z6J5, Q9H0U5, Q9HCI8, Q9NXS0, SUHW4, uc317ili.1, uc317ili.2, Z280D_HUMAN, ZNF634
UCSC ID: ENST00000267807.12_12
RefSeq Accession: NM_017661.4
Protein: Q6N043 (aka Z280D_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.