Human Gene ZNF302 (ENST00000423823.6_5) from GENCODE V47lift37
  Description: zinc finger protein 302, transcript variant 1 (from RefSeq NM_018443.4)
Gencode Transcript: ENST00000423823.6_5
Gencode Gene: ENSG00000089335.22_16
Transcript (Including UTRs)
   Position: hg19 chr19:35,168,594-35,177,296 Size: 8,703 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr19:35,169,710-35,176,142 Size: 6,433 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:35,168,594-35,177,296)mRNA (may differ from genome)Protein (399 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN302_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 302; AltName: Full=Zinc finger protein 135-like; AltName: Full=Zinc finger protein 140-like; AltName: Full=Zinc finger protein 327;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 7 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.94 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 675.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.20236-0.425 Picture PostScript Text
3' UTR -257.801154-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q9NR11
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AL834318 - Homo sapiens mRNA; cDNA DKFZp434M147 (from clone DKFZp434M147).
AK074901 - Homo sapiens cDNA FLJ90420 fis, clone NT2RP3000232, weakly similar to ZINC FINGER PROTEIN 184.
JD556007 - Sequence 537031 from Patent EP1572962.
AF155656 - Homo sapiens zinc finger protein ZNF140-like protein mRNA, complete cds.
AK315241 - Homo sapiens cDNA, FLJ96243.
AF190157 - Homo sapiens MSTP154 (MST154) mRNA, complete cds.
AK297551 - Homo sapiens cDNA FLJ61137 complete cds, highly similar to Zinc finger protein 302.
AK131278 - Homo sapiens cDNA FLJ16225 fis, clone DFNES2011192, highly similar to Homo sapiens zinc finger protein 302 (ZNF302), transcript variant 1, mRNA.
JD458612 - Sequence 439636 from Patent EP1572962.
JD194003 - Sequence 175027 from Patent EP1572962.
BC024176 - Homo sapiens zinc finger protein 302, mRNA (cDNA clone MGC:26095 IMAGE:4822400), complete cds.
AF265236 - Homo sapiens ZNF135-like protein mRNA, complete cds.
AF326206 - Homo sapiens ZNF140-like transcription factor mRNA, complete cds.
JD174348 - Sequence 155372 from Patent EP1572962.
AY251166 - Homo sapiens HSD16 mRNA, complete cds.
AB209226 - Homo sapiens mRNA for PREDICTED: similar to regulator of sex-limitation candidate 11 variant protein.
AK122855 - Homo sapiens cDNA FLJ16476 fis, clone BRSSN2017530, highly similar to Homo sapiens zinc finger protein 302 (ZNF302), transcript variant 1, mRNA.
AL359947 - Homo sapiens mRNA; cDNA DKFZp547C146 (from clone DKFZp547C146).
CU692860 - Synthetic construct Homo sapiens gateway clone IMAGE:100018217 5' read ZNF302 mRNA.
AB587359 - Synthetic construct DNA, clone: pF1KB0946, Homo sapiens ZNF302 gene for zinc finger protein 302, without stop codon, in Flexi system.
HQ447231 - Synthetic construct Homo sapiens clone IMAGE:100070534; CCSB001339_01 zinc finger protein 302 (ZNF302) gene, encodes complete protein.
KJ894284 - Synthetic construct Homo sapiens clone ccsbBroadEn_03678 ZNF302 gene, encodes complete protein.
JD229140 - Sequence 210164 from Patent EP1572962.
AL833690 - Homo sapiens mRNA; cDNA DKFZp667K228 (from clone DKFZp667K228).
AY500357 - Homo sapiens zinc finger protein 17 (HZF17) mRNA, partial cds.
JD052236 - Sequence 33260 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
AL162002 - Homo sapiens mRNA; cDNA DKFZp434I0114 (from clone DKFZp434I0114).
JD103622 - Sequence 84646 from Patent EP1572962.
JD314876 - Sequence 295900 from Patent EP1572962.
JD563814 - Sequence 544838 from Patent EP1572962.
JD326466 - Sequence 307490 from Patent EP1572962.
JD110372 - Sequence 91396 from Patent EP1572962.
JD244459 - Sequence 225483 from Patent EP1572962.
JD239272 - Sequence 220296 from Patent EP1572962.
JD150163 - Sequence 131187 from Patent EP1572962.
JD385392 - Sequence 366416 from Patent EP1572962.
JD345995 - Sequence 327019 from Patent EP1572962.
JD046898 - Sequence 27922 from Patent EP1572962.
JD093505 - Sequence 74529 from Patent EP1572962.
JD551476 - Sequence 532500 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NR11 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000423823.1, ENST00000423823.2, ENST00000423823.3, ENST00000423823.4, ENST00000423823.5, NM_018443, Q658J3, Q9BZD8, Q9NR11, Q9P0J4, uc319tcm.1, ZN302_HUMAN, ZNF135L, ZNF140L, ZNF327
UCSC ID: ENST00000423823.6_5
RefSeq Accession: NM_018443.4
Protein: Q9NR11 (aka ZN302_HUMAN or Z302_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.