Human Gene ZNF318 (ENST00000361428.3_11) from GENCODE V47lift37
  Description: zinc finger protein 318 (from RefSeq NM_014345.3)
Gencode Transcript: ENST00000361428.3_11
Gencode Gene: ENSG00000171467.16_12
Transcript (Including UTRs)
   Position: hg19 chr6:43,303,808-43,337,385 Size: 33,578 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr6:43,304,896-43,337,103 Size: 32,208 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:43,303,808-43,337,385)mRNA (may differ from genome)Protein (2279 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN318_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 318; AltName: Full=Endocrine regulatory protein;
FUNCTION: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).
SUBUNIT: Interacts with the N-terminal domain of AR (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in endocrine tissue.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 2 matrin-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAD17298.1; Type=Erroneous initiation; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D019327 Copper Sulfate
  • C045037 testosterone-3-carboxymethyloxime-bovine serum albumin conjugate

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.22 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 301.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -183.00282-0.649 Picture PostScript Text
3' UTR -256.701088-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015880 - Znf_C2H2-like
IPR003604 - Znf_U1

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q5VUA4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051321 meiotic cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC030687 - Homo sapiens zinc finger protein 318, mRNA (cDNA clone IMAGE:4824620).
AK027061 - Homo sapiens cDNA: FLJ23408 fis, clone HEP19631, highly similar to AF090114 Homo sapiens unknown mRNA.
AF121141 - Homo sapiens endocrine regulator mRNA, complete cds.
AF090114 - Homo sapiens unknown mRNA.
AK001200 - Homo sapiens cDNA FLJ10338 fis, clone NT2RM2000718, highly similar to Homo sapiens HRIHFB2436 mRNA.
JD510422 - Sequence 491446 from Patent EP1572962.
JD281013 - Sequence 262037 from Patent EP1572962.
JD244074 - Sequence 225098 from Patent EP1572962.
JD199125 - Sequence 180149 from Patent EP1572962.
AB015342 - Homo sapiens HRIHFB2436 mRNA, partial cds.
JD453825 - Sequence 434849 from Patent EP1572962.
JD130226 - Sequence 111250 from Patent EP1572962.
JD251018 - Sequence 232042 from Patent EP1572962.
JD347667 - Sequence 328691 from Patent EP1572962.
JD171539 - Sequence 152563 from Patent EP1572962.
AK025505 - Homo sapiens cDNA: FLJ21852 fis, clone HEP02238, highly similar to AF121141 Homo sapiens endocrine regulator mRNA.
BC098434 - Homo sapiens zinc finger protein 318, mRNA (cDNA clone IMAGE:5920355), partial cds.
JD369050 - Sequence 350074 from Patent EP1572962.
JD467684 - Sequence 448708 from Patent EP1572962.
JD494284 - Sequence 475308 from Patent EP1572962.
JD475986 - Sequence 457010 from Patent EP1572962.
JD106384 - Sequence 87408 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000361428.1, ENST00000361428.2, HRIHFB2436, NM_014345, O94796, Q4G0E4, Q5VUA4, Q8NEM6, Q9UNU8, Q9Y2W9, uc318cbn.1, uc318cbn.2, ZN318_HUMAN
UCSC ID: ENST00000361428.3_11
RefSeq Accession: NM_014345.3
Protein: Q5VUA4 (aka ZN318_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.