Human Gene ZNF35 (ENST00000396056.7_4) from GENCODE V47lift37
  Description: zinc finger protein 35 (from RefSeq NM_003420.4)
Gencode Transcript: ENST00000396056.7_4
Gencode Gene: ENSG00000169981.11_14
Transcript (Including UTRs)
   Position: hg19 chr3:44,690,224-44,702,283 Size: 12,060 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr3:44,692,560-44,701,439 Size: 8,880 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:44,690,224-44,702,283)mRNA (may differ from genome)Protein (527 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNF35_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 35; AltName: Full=Zinc finger protein HF.10;
FUNCTION: May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAA85451.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37343.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA30268.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.77 RPKM in Testis
Total median expression: 115.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.00230-0.326 Picture PostScript Text
3' UTR -241.60844-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on P13682
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0071300 cellular response to retinoic acid

Cellular Component:
GO:0005623 cell
GO:0005634 nucleus
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  KJ892404 - Synthetic construct Homo sapiens clone ccsbBroadEn_01798 ZNF35 gene, encodes complete protein.
AK314821 - Homo sapiens cDNA, FLJ95699, Homo sapiens zinc finger protein 35 (clone HF.10) (ZNF35), mRNA.
AK300581 - Homo sapiens cDNA FLJ50867 complete cds, highly similar to Zinc finger protein 35.
BC013597 - Homo sapiens zinc finger protein 35, mRNA (cDNA clone MGC:17095 IMAGE:4186299), complete cds.
BC015892 - Homo sapiens cDNA clone IMAGE:3910805.
X07289 - Human HF.10 gene mRNA.
AB528014 - Synthetic construct DNA, clone: pF1KB7809, Homo sapiens ZNF35 gene for zinc finger protein 35, without stop codon, in Flexi system.
BT006962 - Homo sapiens zinc finger protein 35 (clone HF.10) mRNA, complete cds.
JD400140 - Sequence 381164 from Patent EP1572962.
JD475342 - Sequence 456366 from Patent EP1572962.
JD320179 - Sequence 301203 from Patent EP1572962.
JD362464 - Sequence 343488 from Patent EP1572962.
JD073719 - Sequence 54743 from Patent EP1572962.
JD445020 - Sequence 426044 from Patent EP1572962.
JD172879 - Sequence 153903 from Patent EP1572962.
JD383260 - Sequence 364284 from Patent EP1572962.
JD133562 - Sequence 114586 from Patent EP1572962.
JD250294 - Sequence 231318 from Patent EP1572962.
JD074262 - Sequence 55286 from Patent EP1572962.
JD050293 - Sequence 31317 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RBU6, ENST00000396056.1, ENST00000396056.2, ENST00000396056.3, ENST00000396056.4, ENST00000396056.5, ENST00000396056.6, NM_003420, P13682, Q53Y54, Q96D01, uc318xym.1, uc318xym.2, ZNF35_HUMAN
UCSC ID: ENST00000396056.7_4
RefSeq Accession: NM_003420.4
Protein: P13682 (aka ZNF35_HUMAN or ZN35_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.