Human Gene ZNF445 (ENST00000396077.8_7) from GENCODE V47lift37
  Description: zinc finger protein 445, transcript variant 1 (from RefSeq NM_181489.6)
Gencode Transcript: ENST00000396077.8_7
Gencode Gene: ENSG00000185219.18_10
Transcript (Including UTRs)
   Position: hg19 chr3:44,473,197-44,519,162 Size: 45,966 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr3:44,488,067-44,497,041 Size: 8,975 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:44,473,197-44,519,162)mRNA (may differ from genome)Protein (1031 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN445_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 445; AltName: Full=Zinc finger protein 168; AltName: Full=Zinc finger protein with KRAB and SCAN domains 15;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 14 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SIMILARITY: Contains 1 SCAN box domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.36 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 175.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -142.70348-0.410 Picture PostScript Text
3' UTR -5565.2014870-0.374 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF02023 - SCAN domain
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
47353 - Retrovirus capsid dimerization domain-like
57184 - Growth factor receptor domain
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on P59923
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  JD434966 - Sequence 415990 from Patent EP1572962.
JD529740 - Sequence 510764 from Patent EP1572962.
JD516212 - Sequence 497236 from Patent EP1572962.
DQ596202 - Homo sapiens piRNA piR-34268, complete sequence.
JD311840 - Sequence 292864 from Patent EP1572962.
JD076475 - Sequence 57499 from Patent EP1572962.
JD096823 - Sequence 77847 from Patent EP1572962.
AK026891 - Homo sapiens cDNA: FLJ23238 fis, clone COL00947.
AY295873 - Homo sapiens zinc finger protein mRNA, complete cds.
JD125812 - Sequence 106836 from Patent EP1572962.
JD055309 - Sequence 36333 from Patent EP1572962.
JD306444 - Sequence 287468 from Patent EP1572962.
JD169810 - Sequence 150834 from Patent EP1572962.
JD529504 - Sequence 510528 from Patent EP1572962.
BC052953 - Homo sapiens zinc finger protein 445, mRNA (cDNA clone IMAGE:5302566).
AL832553 - Homo sapiens mRNA; cDNA DKFZp547L0917 (from clone DKFZp547L0917).
JD358484 - Sequence 339508 from Patent EP1572962.
JD229326 - Sequence 210350 from Patent EP1572962.
JD316873 - Sequence 297897 from Patent EP1572962.
JD095545 - Sequence 76569 from Patent EP1572962.
JD054009 - Sequence 35033 from Patent EP1572962.
JD185750 - Sequence 166774 from Patent EP1572962.
JD496363 - Sequence 477387 from Patent EP1572962.
JD081817 - Sequence 62841 from Patent EP1572962.
JD113286 - Sequence 94310 from Patent EP1572962.
JD078775 - Sequence 59799 from Patent EP1572962.
JD283150 - Sequence 264174 from Patent EP1572962.
JD395257 - Sequence 376281 from Patent EP1572962.
JD468120 - Sequence 449144 from Patent EP1572962.
JD039534 - Sequence 20558 from Patent EP1572962.
JD539331 - Sequence 520355 from Patent EP1572962.
JD090893 - Sequence 71917 from Patent EP1572962.
JD045667 - Sequence 26691 from Patent EP1572962.
JD566369 - Sequence 547393 from Patent EP1572962.
JD467900 - Sequence 448924 from Patent EP1572962.
JD133924 - Sequence 114948 from Patent EP1572962.
JD499938 - Sequence 480962 from Patent EP1572962.
JD541369 - Sequence 522393 from Patent EP1572962.
JD382702 - Sequence 363726 from Patent EP1572962.
JD488176 - Sequence 469200 from Patent EP1572962.
JD071906 - Sequence 52930 from Patent EP1572962.
JD352786 - Sequence 333810 from Patent EP1572962.
JC506945 - Sequence 313 from Patent EP2733220.
JC738057 - Sequence 313 from Patent WO2014075939.
JD542029 - Sequence 523053 from Patent EP1572962.
JD505968 - Sequence 486992 from Patent EP1572962.
JD067378 - Sequence 48402 from Patent EP1572962.
JD425861 - Sequence 406885 from Patent EP1572962.
JD255724 - Sequence 236748 from Patent EP1572962.
JD397897 - Sequence 378921 from Patent EP1572962.
JD070253 - Sequence 51277 from Patent EP1572962.
JD122634 - Sequence 103658 from Patent EP1572962.
JD372125 - Sequence 353149 from Patent EP1572962.
JD182565 - Sequence 163589 from Patent EP1572962.
JD373459 - Sequence 354483 from Patent EP1572962.
JD275170 - Sequence 256194 from Patent EP1572962.
JD541259 - Sequence 522283 from Patent EP1572962.
JD496778 - Sequence 477802 from Patent EP1572962.
JD384440 - Sequence 365464 from Patent EP1572962.
JD234232 - Sequence 215256 from Patent EP1572962.
JD221064 - Sequence 202088 from Patent EP1572962.
JD078186 - Sequence 59210 from Patent EP1572962.
JD373838 - Sequence 354862 from Patent EP1572962.
JD318496 - Sequence 299520 from Patent EP1572962.
JD438323 - Sequence 419347 from Patent EP1572962.
JD293538 - Sequence 274562 from Patent EP1572962.
JD293537 - Sequence 274561 from Patent EP1572962.
JD234231 - Sequence 215255 from Patent EP1572962.
JD270561 - Sequence 251585 from Patent EP1572962.
JD234230 - Sequence 215254 from Patent EP1572962.
JD550371 - Sequence 531395 from Patent EP1572962.
JD428396 - Sequence 409420 from Patent EP1572962.
JD210883 - Sequence 191907 from Patent EP1572962.
JD377188 - Sequence 358212 from Patent EP1572962.
JD147466 - Sequence 128490 from Patent EP1572962.
JD223417 - Sequence 204441 from Patent EP1572962.
JD086774 - Sequence 67798 from Patent EP1572962.
JD409753 - Sequence 390777 from Patent EP1572962.
JD509656 - Sequence 490680 from Patent EP1572962.
JD340619 - Sequence 321643 from Patent EP1572962.
JD488622 - Sequence 469646 from Patent EP1572962.
JD482337 - Sequence 463361 from Patent EP1572962.
JD391053 - Sequence 372077 from Patent EP1572962.
JD292742 - Sequence 273766 from Patent EP1572962.
JD181465 - Sequence 162489 from Patent EP1572962.
JD417912 - Sequence 398936 from Patent EP1572962.
JD078371 - Sequence 59395 from Patent EP1572962.
JD304079 - Sequence 285103 from Patent EP1572962.
JD049135 - Sequence 30159 from Patent EP1572962.
JD303265 - Sequence 284289 from Patent EP1572962.
AY262260 - Homo sapiens zinc finger protein (ZNF445) mRNA, complete cds.
BC101486 - Homo sapiens zinc finger protein 445, mRNA (cDNA clone MGC:126535 IMAGE:8068992), complete cds.
BC143439 - Homo sapiens cDNA clone MGC:176964 IMAGE:9051947, complete cds.
JD350061 - Sequence 331085 from Patent EP1572962.
AB385201 - Synthetic construct DNA, clone: pF1KB9288, Homo sapiens ZNF445 gene for zinc finger protein 445, complete cds, without stop codon, in Flexi system.
AF024702 - Homo sapiens clone B1-10 zinc finger protein mRNA, partial cds.
AF027137 - Homo sapiens clone B1-11 zinc finger protein mRNA, partial cds.
L32162 - Homo sapiens transcription factor mRNA, 5' end.
AY279350 - Homo sapiens truncated zinc finger protein 445 isoform (ZNF445) mRNA, complete cds.
JD136010 - Sequence 117034 from Patent EP1572962.
AK310588 - Homo sapiens cDNA, FLJ17630.
JD154781 - Sequence 135805 from Patent EP1572962.
JD226704 - Sequence 207728 from Patent EP1572962.
JD552416 - Sequence 533440 from Patent EP1572962.
JD297153 - Sequence 278177 from Patent EP1572962.
JD072059 - Sequence 53083 from Patent EP1572962.
JD072060 - Sequence 53084 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P59923 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000396077.1, ENST00000396077.2, ENST00000396077.3, ENST00000396077.4, ENST00000396077.5, ENST00000396077.6, ENST00000396077.7, NM_181489, P59923, Q3MJD1, uc318xzb.1, uc318xzb.2, ZFP445 , ZKSCAN15, ZN445_HUMAN, ZNF168, ZNF445
UCSC ID: ENST00000396077.8_7
RefSeq Accession: NM_181489.6
Protein: P59923 (aka ZN445_HUMAN or Z445_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.