Human Gene ZNF461 (ENST00000588268.6_10) from GENCODE V47lift37

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Description: zinc finger protein 461, transcript variant 1 (from RefSeq NM_153257.5)
Gencode Transcript: ENST00000588268.6_10
Gencode Gene: ENSG00000197808.14_17
Transcript (Including UTRs)
Position: hg19 chr19:37,127,520-37,157,739 Size: 30,220 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr19:37,129,555-37,155,608 Size: 26,054 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:37,127,520-37,157,739)			mRNA (may differ from genome)		Protein (563 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZN461_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 461; AltName: Full=Gonadotropin-inducible ovary transcription repressor 1; Short=GIOT-1; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 12 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D019327 Copper Sulfate D005576 Forskolin C030973 cupric oxide C016599 mono-(2-ethylhexyl)phthalate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.88 RPKM in Brain - Cerebellar Hemisphere Total median expression: 83.99 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-58.30	228	-0.256	Picture	PostScript	Text
3' UTR	-634.10	2035	-0.312	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q8TAF7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	JD160364 - Sequence 141388 from Patent EP1572962. JD178282 - Sequence 159306 from Patent EP1572962. BX649031 - Homo sapiens mRNA; cDNA DKFZp686F1298 (from clone DKFZp686F1298). AB021641 - Homo sapiens GIOT-1 mRNA for gonadotropin inducible transcription repressor-1, partial cds. JD374489 - Sequence 355513 from Patent EP1572962. JD388852 - Sequence 369876 from Patent EP1572962. JD388853 - Sequence 369877 from Patent EP1572962. JD321261 - Sequence 302285 from Patent EP1572962. JD321262 - Sequence 302286 from Patent EP1572962. JD388849 - Sequence 369873 from Patent EP1572962. JD388850 - Sequence 369874 from Patent EP1572962. JD321259 - Sequence 302283 from Patent EP1572962. JD492049 - Sequence 473073 from Patent EP1572962. JD513530 - Sequence 494554 from Patent EP1572962. JD365480 - Sequence 346504 from Patent EP1572962. JD513529 - Sequence 494553 from Patent EP1572962. AY329493 - Homo sapiens gonadotropin inducible transcription repressor-1 mRNA, complete cds. AK299370 - Homo sapiens cDNA FLJ54872 complete cds, highly similar to Zinc finger protein 461. AK292834 - Homo sapiens cDNA FLJ77241 complete cds, highly similar to Homo sapiens gonadotropin inducible transcription repressor 1 (GIOT-1), mRNA. AB209279 - Homo sapiens mRNA for gonadotropin inducible transcription repressor 1 variant protein. BC028631 - Homo sapiens zinc finger protein 461, mRNA (cDNA clone MGC:33911 IMAGE:5265256), complete cds. KJ903583 - Synthetic construct Homo sapiens clone ccsbBroadEn_12977 ZNF461 gene, encodes complete protein. DQ891185 - Synthetic construct clone IMAGE:100003815; FLH169961.01X; RZPDo839A0398D zinc finger protein 461 (ZNF461) gene, encodes complete protein. DQ894367 - Synthetic construct Homo sapiens clone IMAGE:100008827; FLH169957.01L; RZPDo839A0397D zinc finger protein 461 (ZNF461) gene, encodes complete protein. AB384904 - Synthetic construct DNA, clone: pF1KB4139, Homo sapiens ZNF461 gene for zinc finger protein 461, complete cds, without stop codon, in Flexi system. AY500360 - Homo sapiens zinc finger protein 28 (HZF28) mRNA, partial cds. JD025592 - Sequence 6616 from Patent EP1572962. JD032199 - Sequence 13223 from Patent EP1572962. JD316290 - Sequence 297314 from Patent EP1572962. JD314886 - Sequence 295910 from Patent EP1572962. JD314887 - Sequence 295911 from Patent EP1572962. JD246154 - Sequence 227178 from Patent EP1572962. JD314887 - Sequence 295911 from Patent EP1572962. JD314886 - Sequence 295910 from Patent EP1572962. JD023467 - Sequence 4491 from Patent EP1572962. JD035092 - Sequence 16116 from Patent EP1572962. JD031252 - Sequence 12276 from Patent EP1572962. JD314886 - Sequence 295910 from Patent EP1572962. JD314887 - Sequence 295911 from Patent EP1572962. JD047452 - Sequence 28476 from Patent EP1572962. CU688536 - Synthetic construct Homo sapiens gateway clone IMAGE:100019390 5' read ZNF461 mRNA. JD532317 - Sequence 513341 from Patent EP1572962. JD175099 - Sequence 156123 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q8TAF7 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: A8K9W9, ENST00000588268.1, ENST00000588268.2, ENST00000588268.3, ENST00000588268.4, ENST00000588268.5, GIOT1, NM_153257, Q6VSF7, Q8TAF7, Q9ULZ8, uc326sir.1, uc326sir.2, ZN461_HUMAN UCSC ID: ENST00000588268.6_10 RefSeq Accession: NM_153257.5 Protein: Q8TAF7 (aka ZN461_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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