Human Gene ZNF510 (ENST00000223428.9_8) from GENCODE V47lift37
  Description: zinc finger protein 510, transcript variant 2 (from RefSeq NM_014930.3)
Gencode Transcript: ENST00000223428.9_8
Gencode Gene: ENSG00000081386.13_10
Transcript (Including UTRs)
   Position: hg19 chr9:99,516,835-99,540,369 Size: 23,535 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr9:99,521,060-99,538,351 Size: 17,292 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:99,516,835-99,540,369)mRNA (may differ from genome)Protein (683 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN510_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 510;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 10 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAA76816.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.73 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 127.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.40230-0.323 Picture PostScript Text
3' UTR -1171.404225-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
82919 - Zn-finger domain of Sec23/24
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on Q9Y2H8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AB023189 - Homo sapiens KIAA0972 mRNA for KIAA0972 protein.
JD046278 - Sequence 27302 from Patent EP1572962.
DQ589510 - Homo sapiens piRNA piR-56622, complete sequence.
JD122829 - Sequence 103853 from Patent EP1572962.
JD301367 - Sequence 282391 from Patent EP1572962.
JD298324 - Sequence 279348 from Patent EP1572962.
JD049350 - Sequence 30374 from Patent EP1572962.
JD501841 - Sequence 482865 from Patent EP1572962.
JD549380 - Sequence 530404 from Patent EP1572962.
JD150568 - Sequence 131592 from Patent EP1572962.
JD210161 - Sequence 191185 from Patent EP1572962.
JD039200 - Sequence 20224 from Patent EP1572962.
JD467921 - Sequence 448945 from Patent EP1572962.
JD345915 - Sequence 326939 from Patent EP1572962.
JD296473 - Sequence 277497 from Patent EP1572962.
JD221219 - Sequence 202243 from Patent EP1572962.
JD322043 - Sequence 303067 from Patent EP1572962.
JD099560 - Sequence 80584 from Patent EP1572962.
JD060014 - Sequence 41038 from Patent EP1572962.
JD552070 - Sequence 533094 from Patent EP1572962.
JD201186 - Sequence 182210 from Patent EP1572962.
JD239839 - Sequence 220863 from Patent EP1572962.
JD358126 - Sequence 339150 from Patent EP1572962.
JD255307 - Sequence 236331 from Patent EP1572962.
JD271035 - Sequence 252059 from Patent EP1572962.
JD311313 - Sequence 292337 from Patent EP1572962.
JD128301 - Sequence 109325 from Patent EP1572962.
AK292600 - Homo sapiens cDNA FLJ75860 complete cds, highly similar to Homo sapiens zinc finger protein 510 (ZNF510), mRNA.
JD348450 - Sequence 329474 from Patent EP1572962.
JD504385 - Sequence 485409 from Patent EP1572962.
JD331207 - Sequence 312231 from Patent EP1572962.
JD447490 - Sequence 428514 from Patent EP1572962.
JD347400 - Sequence 328424 from Patent EP1572962.
JD307283 - Sequence 288307 from Patent EP1572962.
JD448957 - Sequence 429981 from Patent EP1572962.
JD440943 - Sequence 421967 from Patent EP1572962.
JD493626 - Sequence 474650 from Patent EP1572962.
JD079442 - Sequence 60466 from Patent EP1572962.
AB463368 - Synthetic construct DNA, clone: pF1KA0972, Homo sapiens ZNF510 gene for zinc finger protein 510, without stop codon, in Flexi system.
EU446778 - Synthetic construct Homo sapiens clone IMAGE:100070052; IMAGE:100011987; FLH258297.01L zinc finger protein 510 (ZNF510) gene, encodes complete protein.
BC036676 - Homo sapiens zinc finger protein 510, mRNA (cDNA clone MGC:33740 IMAGE:4792684), complete cds.
BC068587 - Homo sapiens zinc finger protein 510, mRNA (cDNA clone MGC:87593 IMAGE:4374918), complete cds.
JD314818 - Sequence 295842 from Patent EP1572962.
JD306488 - Sequence 287512 from Patent EP1572962.
BC058022 - Homo sapiens zinc finger protein 510, mRNA (cDNA clone IMAGE:4273747), partial cds.
JD332810 - Sequence 313834 from Patent EP1572962.
JD303503 - Sequence 284527 from Patent EP1572962.
JD077002 - Sequence 58026 from Patent EP1572962.
JD437935 - Sequence 418959 from Patent EP1572962.
JD260148 - Sequence 241172 from Patent EP1572962.
JD056063 - Sequence 37087 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y2H8 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000223428.1, ENST00000223428.2, ENST00000223428.3, ENST00000223428.4, ENST00000223428.5, ENST00000223428.6, ENST00000223428.7, ENST00000223428.8, KIAA0972, NM_014930, Q5SZP5, Q9Y2H8, uc317dhm.1, uc317dhm.2, ZN510_HUMAN
UCSC ID: ENST00000223428.9_8
RefSeq Accession: NM_014930.3
Protein: Q9Y2H8 (aka ZN510_HUMAN or Z510_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.