Human Gene ZNF512B (ENST00000369888.6_7) from GENCODE V47lift37
  Description: zinc finger protein 512B (from RefSeq NM_020713.3)
Gencode Transcript: ENST00000369888.6_7
Gencode Gene: ENSG00000196700.9_10
Transcript (Including UTRs)
   Position: hg19 chr20:62,588,057-62,601,283 Size: 13,227 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr20:62,591,241-62,599,303 Size: 8,063 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:62,588,057-62,601,283)mRNA (may differ from genome)Protein (892 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Z512B_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 512B;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 7 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF512B
Diseases sorted by gene-association score: amyotrophic lateral sclerosis 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.21 RPKM in Pituitary
Total median expression: 479.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.50119-0.534 Picture PostScript Text
3' UTR -1524.103184-0.479 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2GQJ - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q96KM6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AB033022 - Homo sapiens mRNA for KIAA1196 protein, partial cds.
AL834525 - Homo sapiens mRNA; cDNA DKFZp434N2010 (from clone DKFZp434N2010).
JD048593 - Sequence 29617 from Patent EP1572962.
JD129372 - Sequence 110396 from Patent EP1572962.
JD344558 - Sequence 325582 from Patent EP1572962.
JD226642 - Sequence 207666 from Patent EP1572962.
JD210215 - Sequence 191239 from Patent EP1572962.
JD385163 - Sequence 366187 from Patent EP1572962.
JD427245 - Sequence 408269 from Patent EP1572962.
JD495459 - Sequence 476483 from Patent EP1572962.
JD191142 - Sequence 172166 from Patent EP1572962.
JD257198 - Sequence 238222 from Patent EP1572962.
JD399577 - Sequence 380601 from Patent EP1572962.
JD283414 - Sequence 264438 from Patent EP1572962.
JD241873 - Sequence 222897 from Patent EP1572962.
JD110482 - Sequence 91506 from Patent EP1572962.
JD052111 - Sequence 33135 from Patent EP1572962.
JD248601 - Sequence 229625 from Patent EP1572962.
JD045704 - Sequence 26728 from Patent EP1572962.
JD392206 - Sequence 373230 from Patent EP1572962.
JD227244 - Sequence 208268 from Patent EP1572962.
JD317077 - Sequence 298101 from Patent EP1572962.
JD185890 - Sequence 166914 from Patent EP1572962.
JD445875 - Sequence 426899 from Patent EP1572962.
JD445876 - Sequence 426900 from Patent EP1572962.
JD474913 - Sequence 455937 from Patent EP1572962.
JD540775 - Sequence 521799 from Patent EP1572962.
JD287537 - Sequence 268561 from Patent EP1572962.
JD556044 - Sequence 537068 from Patent EP1572962.
JD540915 - Sequence 521939 from Patent EP1572962.
JD121988 - Sequence 103012 from Patent EP1572962.
JD370479 - Sequence 351503 from Patent EP1572962.
JD468018 - Sequence 449042 from Patent EP1572962.
JD548259 - Sequence 529283 from Patent EP1572962.
JD039817 - Sequence 20841 from Patent EP1572962.
JD233938 - Sequence 214962 from Patent EP1572962.
JD205456 - Sequence 186480 from Patent EP1572962.
JD225626 - Sequence 206650 from Patent EP1572962.
JD213906 - Sequence 194930 from Patent EP1572962.
JD265428 - Sequence 246452 from Patent EP1572962.
JD475343 - Sequence 456367 from Patent EP1572962.
JD076824 - Sequence 57848 from Patent EP1572962.
JD217190 - Sequence 198214 from Patent EP1572962.
JD278208 - Sequence 259232 from Patent EP1572962.
JD426659 - Sequence 407683 from Patent EP1572962.
JD525972 - Sequence 506996 from Patent EP1572962.
JD384448 - Sequence 365472 from Patent EP1572962.
JD518623 - Sequence 499647 from Patent EP1572962.
JD077566 - Sequence 58590 from Patent EP1572962.
JD066166 - Sequence 47190 from Patent EP1572962.
JD485766 - Sequence 466790 from Patent EP1572962.
JD519865 - Sequence 500889 from Patent EP1572962.
JD108499 - Sequence 89523 from Patent EP1572962.
JD515081 - Sequence 496105 from Patent EP1572962.
JD127362 - Sequence 108386 from Patent EP1572962.
JD291962 - Sequence 272986 from Patent EP1572962.
JD548333 - Sequence 529357 from Patent EP1572962.
JD497208 - Sequence 478232 from Patent EP1572962.
JD465396 - Sequence 446420 from Patent EP1572962.
JD425508 - Sequence 406532 from Patent EP1572962.
JD475880 - Sequence 456904 from Patent EP1572962.
JD540508 - Sequence 521532 from Patent EP1572962.
JD106192 - Sequence 87216 from Patent EP1572962.
JD233559 - Sequence 214583 from Patent EP1572962.
JD498715 - Sequence 479739 from Patent EP1572962.
JD121752 - Sequence 102776 from Patent EP1572962.
JD501421 - Sequence 482445 from Patent EP1572962.
JD291341 - Sequence 272365 from Patent EP1572962.
JD394244 - Sequence 375268 from Patent EP1572962.
JD487585 - Sequence 468609 from Patent EP1572962.
JD456123 - Sequence 437147 from Patent EP1572962.
JD264232 - Sequence 245256 from Patent EP1572962.
JD197021 - Sequence 178045 from Patent EP1572962.
JD382972 - Sequence 363996 from Patent EP1572962.
JD320267 - Sequence 301291 from Patent EP1572962.
JD255564 - Sequence 236588 from Patent EP1572962.
JD274906 - Sequence 255930 from Patent EP1572962.
JD495492 - Sequence 476516 from Patent EP1572962.
JD341590 - Sequence 322614 from Patent EP1572962.
JD407743 - Sequence 388767 from Patent EP1572962.
JD390621 - Sequence 371645 from Patent EP1572962.
BC125129 - Homo sapiens zinc finger protein 512B, mRNA (cDNA clone MGC:149846 IMAGE:40119053), complete cds.
BC125128 - Homo sapiens zinc finger protein 512B, mRNA (cDNA clone MGC:149845 IMAGE:40119047), complete cds.
JD344426 - Sequence 325450 from Patent EP1572962.
JD362426 - Sequence 343450 from Patent EP1572962.
JD498925 - Sequence 479949 from Patent EP1572962.
JD383308 - Sequence 364332 from Patent EP1572962.
JD389896 - Sequence 370920 from Patent EP1572962.
JD191004 - Sequence 172028 from Patent EP1572962.
JD193531 - Sequence 174555 from Patent EP1572962.
KJ899338 - Synthetic construct Homo sapiens clone ccsbBroadEn_08732 ZNF512B gene, encodes complete protein.
KJ899339 - Synthetic construct Homo sapiens clone ccsbBroadEn_08733 ZNF512B gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000369888.1, ENST00000369888.2, ENST00000369888.3, ENST00000369888.4, ENST00000369888.5, KIAA1196, NM_020713, Q08AK9, Q96KM6, Q9ULM4, uc318hxz.1, uc318hxz.2, Z512B_HUMAN
UCSC ID: ENST00000369888.6_7
RefSeq Accession: NM_020713.3
Protein: Q96KM6 (aka Z512B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.