Human Gene ZNF541 (ENST00000391901.8_9) from GENCODE V47lift37
  Description: zinc finger protein 541 (from RefSeq NM_001277075.3)
Gencode Transcript: ENST00000391901.8_9
Gencode Gene: ENSG00000118156.13_11
Transcript (Including UTRs)
   Position: hg19 chr19:48,023,947-48,076,405 Size: 52,459 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr19:48,024,481-48,059,113 Size: 34,633 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:48,023,947-48,076,405)mRNA (may differ from genome)Protein (1346 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN541_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 541;
FUNCTION: Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (By similarity).
SUBUNIT: Interacts with HDAC1 and HSPA2 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SIMILARITY: Contains 1 ELM2 domain.
SIMILARITY: Contains 1 SANT domain.
SEQUENCE CAUTION: Sequence=AAI01051.1; Type=Erroneous initiation; Sequence=AAI01052.1; Type=Erroneous initiation; Sequence=AAI01053.1; Type=Erroneous initiation; Sequence=AAI01054.1; Type=Erroneous initiation; Sequence=CAB66780.1; Type=Erroneous initiation; Sequence=CAD38720.2; Type=Frameshift; Positions=473;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.93 RPKM in Testis
Total median expression: 30.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.90311-0.379 Picture PostScript Text
3' UTR -187.70534-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000949 - ELM2_dom
IPR009057 - Homeodomain-like
IPR001005 - SANT/Myb
IPR017884 - SANT_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01448 - ELM2 domain
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
46689 - Homeodomain-like
57667 - beta-beta-alpha zinc fingers
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q9H0D2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0008134 transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation

Cellular Component:
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005667 transcription factor complex


-  Descriptions from all associated GenBank mRNAs
  AL136846 - Homo sapiens mRNA; cDNA DKFZp434I1930 (from clone DKFZp434I1930).
AL833862 - Homo sapiens mRNA; cDNA DKFZp434J1526 (from clone DKFZp434J1526).
JD434209 - Sequence 415233 from Patent EP1572962.
BC101050 - Homo sapiens zinc finger protein 541, mRNA (cDNA clone MGC:119518 IMAGE:40008070), complete cds.
BC101051 - Homo sapiens zinc finger protein 541, mRNA (cDNA clone MGC:119519 IMAGE:40008071), complete cds.
BC101052 - Homo sapiens zinc finger protein 541, mRNA (cDNA clone MGC:119520 IMAGE:40008072), complete cds.
BC101053 - Homo sapiens zinc finger protein 541, mRNA (cDNA clone MGC:119521 IMAGE:40008073), complete cds.
JD368564 - Sequence 349588 from Patent EP1572962.
JD402202 - Sequence 383226 from Patent EP1572962.
JD243424 - Sequence 224448 from Patent EP1572962.
JD110515 - Sequence 91539 from Patent EP1572962.
JD520730 - Sequence 501754 from Patent EP1572962.
JD188438 - Sequence 169462 from Patent EP1572962.
JD484791 - Sequence 465815 from Patent EP1572962.
AK314169 - Homo sapiens cDNA, FLJ94882.
JD176961 - Sequence 157985 from Patent EP1572962.
JD227519 - Sequence 208543 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000391901.1, ENST00000391901.2, ENST00000391901.3, ENST00000391901.4, ENST00000391901.5, ENST00000391901.6, ENST00000391901.7, NM_001277075, Q8NDK8, Q9H0D2, uc318urs.1, uc318urs.2, ZN541_HUMAN
UCSC ID: ENST00000391901.8_9
RefSeq Accession: NM_001277075.3
Protein: Q9H0D2 (aka ZN541_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.