Human Gene ZNF575 (ENST00000314228.10_3) from GENCODE V47lift37
  Description: zinc finger protein 575, transcript variant 1 (from RefSeq NM_174945.3)
Gencode Transcript: ENST00000314228.10_3
Gencode Gene: ENSG00000176472.11_8
Transcript (Including UTRs)
   Position: hg19 chr19:44,037,340-44,040,239 Size: 2,900 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr19:44,038,575-44,039,839 Size: 1,265 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:44,037,340-44,040,239)mRNA (may differ from genome)Protein (245 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN575_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 575;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 6 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.33 RPKM in Brain - Cerebellum
Total median expression: 86.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -233.30528-0.442 Picture PostScript Text
3' UTR -127.30400-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q86XF7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK057129 - Homo sapiens cDNA FLJ32567 fis, clone SPLEN2000072, highly similar to Zinc finger protein 575.
BC043611 - Homo sapiens zinc finger protein 575, mRNA (cDNA clone MGC:50892 IMAGE:6018699), complete cds.
AK301820 - Homo sapiens cDNA FLJ50905 complete cds, highly similar to Zinc finger protein 575.
JD399030 - Sequence 380054 from Patent EP1572962.
JD251723 - Sequence 232747 from Patent EP1572962.
JD337019 - Sequence 318043 from Patent EP1572962.
JD354935 - Sequence 335959 from Patent EP1572962.
JD417981 - Sequence 399005 from Patent EP1572962.
JD085972 - Sequence 66996 from Patent EP1572962.
KJ900565 - Synthetic construct Homo sapiens clone ccsbBroadEn_09959 ZNF575 gene, encodes complete protein.
JD540483 - Sequence 521507 from Patent EP1572962.
JD403322 - Sequence 384346 from Patent EP1572962.
JD226572 - Sequence 207596 from Patent EP1572962.
JD382729 - Sequence 363753 from Patent EP1572962.
JD436899 - Sequence 417923 from Patent EP1572962.
JD464391 - Sequence 445415 from Patent EP1572962.
JD263332 - Sequence 244356 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DX54, ENST00000314228.1, ENST00000314228.2, ENST00000314228.3, ENST00000314228.4, ENST00000314228.5, ENST00000314228.6, ENST00000314228.7, ENST00000314228.8, ENST00000314228.9, NM_174945, Q86XF7, uc317poo.1, uc317poo.2, ZN575_HUMAN
UCSC ID: ENST00000314228.10_3
RefSeq Accession: NM_174945.3
Protein: Q86XF7 (aka ZN575_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.