Human Gene ZNF600 (ENST00000338230.3_7) from GENCODE V47lift37
  Description: zinc finger protein 600, transcript variant 1 (from RefSeq NM_198457.5)
Gencode Transcript: ENST00000338230.3_7
Gencode Gene: ENSG00000189190.11_15
Transcript (Including UTRs)
   Position: hg19 chr19:53,267,448-53,290,016 Size: 22,569 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:53,268,840-53,271,008 Size: 2,169 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:53,267,448-53,290,016)mRNA (may differ from genome)Protein (722 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN600_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 600;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 20 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.45 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 130.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.00268-0.343 Picture PostScript Text
3' UTR -413.601392-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
82657 - BolA-like
57667 - beta-beta-alpha zinc fingers
82919 - Zn-finger domain of Sec23/24
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q6ZNG1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BX640933 - Homo sapiens mRNA; cDNA DKFZp686F06123 (from clone DKFZp686F06123).
JD417686 - Sequence 398710 from Patent EP1572962.
JD143475 - Sequence 124499 from Patent EP1572962.
JD243358 - Sequence 224382 from Patent EP1572962.
DQ596756 - Homo sapiens piRNA piR-34822, complete sequence.
JD340972 - Sequence 321996 from Patent EP1572962.
JD179309 - Sequence 160333 from Patent EP1572962.
JD179308 - Sequence 160332 from Patent EP1572962.
JD481211 - Sequence 462235 from Patent EP1572962.
JD490384 - Sequence 471408 from Patent EP1572962.
JD081994 - Sequence 63018 from Patent EP1572962.
JD266668 - Sequence 247692 from Patent EP1572962.
JD266669 - Sequence 247693 from Patent EP1572962.
JD247925 - Sequence 228949 from Patent EP1572962.
JD431470 - Sequence 412494 from Patent EP1572962.
JD083517 - Sequence 64541 from Patent EP1572962.
JD314870 - Sequence 295894 from Patent EP1572962.
AK075230 - Homo sapiens cDNA FLJ90749 fis, clone PLACE1011978, moderately similar to ZINC FINGER PROTEIN 91.
AK131231 - Homo sapiens cDNA FLJ16140 fis, clone BRAMY2035070, moderately similar to Homo sapiens zinc finger 1111 mRNA.
JD374750 - Sequence 355774 from Patent EP1572962.
JD039812 - Sequence 20836 from Patent EP1572962.
U52096 - Human zinc finger protein (kr-znf1) mRNA, partial cds.
JD516149 - Sequence 497173 from Patent EP1572962.
JD314888 - Sequence 295912 from Patent EP1572962.
JD330513 - Sequence 311537 from Patent EP1572962.
JD330514 - Sequence 311538 from Patent EP1572962.
JD330515 - Sequence 311539 from Patent EP1572962.
JD330516 - Sequence 311540 from Patent EP1572962.
JD314875 - Sequence 295899 from Patent EP1572962.
JD357708 - Sequence 338732 from Patent EP1572962.
JD314851 - Sequence 295875 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6ZNG1 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000338230.1, ENST00000338230.2, NM_198457, Q6MZR0, Q6ZNG1, uc317uyr.1, uc317uyr.2, ZN600_HUMAN
UCSC ID: ENST00000338230.3_7
RefSeq Accession: NM_198457.5
Protein: Q6ZNG1 (aka ZN600_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.