ID:ZN622_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 622; AltName: Full=Zinc finger-like protein 9; FUNCTION: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development. SUBUNIT: Homo- and heterodimer. Interacts with MELK and MYBL2. INTERACTION: Q99683:MAP3K5; NbExp=14; IntAct=EBI-2687480, EBI-476263; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney. PTM: Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus. SIMILARITY: Contains 2 U1-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969S3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0046872 metal ion binding
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0033674 positive regulation of kinase activity GO:0042273 ribosomal large subunit biogenesis GO:0043065 positive regulation of apoptotic process GO:0043410 positive regulation of MAPK cascade GO:0046330 positive regulation of JNK cascade
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
