Human Gene ZNF630 (ENST00000276054.9_6) from GENCODE V47lift37
  Description: zinc finger protein 630, transcript variant 4 (from RefSeq NM_001282202.3)
Gencode Transcript: ENST00000276054.9_6
Gencode Gene: ENSG00000221994.12_13
Transcript (Including UTRs)
   Position: hg19 chrX:47,916,905-47,931,007 Size: 14,103 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chrX:47,917,857-47,926,274 Size: 8,418 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:47,916,905-47,931,007)mRNA (may differ from genome)Protein (657 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN630_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 630;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.45 RPKM in Prostate
Total median expression: 60.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -188.20549-0.343 Picture PostScript Text
3' UTR -244.80952-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q2M218
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK308650 - Homo sapiens cDNA, FLJ98691.
AK000580 - Homo sapiens cDNA FLJ20573 fis, clone REC01089, highly similar to ZN84_HUMAN ZINC FINGER PROTEIN 84.
BC037316 - Homo sapiens zinc finger protein 630, mRNA (cDNA clone IMAGE:5259432).
JD358917 - Sequence 339941 from Patent EP1572962.
JD304598 - Sequence 285622 from Patent EP1572962.
JD363914 - Sequence 344938 from Patent EP1572962.
BC112139 - Homo sapiens zinc finger protein 630, mRNA (cDNA clone MGC:138344 IMAGE:8327607), complete cds.
EU446830 - Synthetic construct Homo sapiens clone IMAGE:100070045; IMAGE:100012039; FLH257171.01L zinc finger protein 630 (ZNF630) gene, encodes complete protein.
AK307979 - Homo sapiens cDNA, FLJ97927.
JD512391 - Sequence 493415 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD357505 - Sequence 338529 from Patent EP1572962.
JD314885 - Sequence 295909 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD215856 - Sequence 196880 from Patent EP1572962.
JD211422 - Sequence 192446 from Patent EP1572962.
JD166988 - Sequence 148012 from Patent EP1572962.
JD399415 - Sequence 380439 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000276054.1, ENST00000276054.2, ENST00000276054.3, ENST00000276054.4, ENST00000276054.5, ENST00000276054.6, ENST00000276054.7, ENST00000276054.8, F8WAG4, NM_001282202, Q2M218, Q5H8Z5, uc317jjd.1, uc317jjd.2, ZN630_HUMAN
UCSC ID: ENST00000276054.9_6
RefSeq Accession: NM_001282201.2
Protein: Q2M218 (aka ZN630_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.