Human Gene ZNF639 (ENST00000496856.6_4) from GENCODE V47lift37
  Description: zinc finger protein 639, transcript variant 7 (from RefSeq NM_001375804.1)
Gencode Transcript: ENST00000496856.6_4
Gencode Gene: ENSG00000121864.10_13
Transcript (Including UTRs)
   Position: hg19 chr3:179,040,819-179,056,371 Size: 15,553 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr3:179,046,082-179,052,210 Size: 6,129 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:179,040,819-179,056,371)mRNA (may differ from genome)Protein (485 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN639_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 639; AltName: Full=Zinc finger protein ANC_2H01; AltName: Full=Zinc finger protein ZASC1;
FUNCTION: Binds DNA and may function as a transcriptional repressor.
SUBUNIT: Interacts with CTNNA2.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 8 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.40 RPKM in Fallopian Tube
Total median expression: 350.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -169.90343-0.495 Picture PostScript Text
3' UTR -1391.704161-0.334 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on Q9UID6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0043621 protein self-association
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0030307 positive regulation of cell growth
GO:0043922 negative regulation by host of viral transcription
GO:0043923 positive regulation by host of viral transcription
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046718 viral entry into host cell

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  BC026181 - Homo sapiens zinc finger protein 639, mRNA (cDNA clone MGC:33027 IMAGE:4794621), complete cds.
AF003924 - Homo sapiens zinc finger protein ANC_2H01 mRNA, complete cds.
AB097862 - Homo sapiens ZASC1 mRNA for Kruppel-like zinc finger protein, complete cds.
AK122884 - Homo sapiens cDNA FLJ16532 fis, clone OCBBF2027481, highly similar to Homo sapiens zinc finger protein ANC_2H01 mRNA.
BC020500 - Homo sapiens zinc finger protein 639, mRNA (cDNA clone MGC:10232 IMAGE:3912907), complete cds.
CU676534 - Synthetic construct Homo sapiens gateway clone IMAGE:100019621 5' read ZNF639 mRNA.
EU446802 - Synthetic construct Homo sapiens clone IMAGE:100070197; IMAGE:100012011; FLH258736.01L zinc finger protein 639 (ZNF639) gene, encodes complete protein.
KJ898853 - Synthetic construct Homo sapiens clone ccsbBroadEn_08247 ZNF639 gene, encodes complete protein.
DQ323613 - Homo sapiens clone 22 zinc finger protein 639 mRNA, partial cds.
JD346472 - Sequence 327496 from Patent EP1572962.
JD318850 - Sequence 299874 from Patent EP1572962.
JD155384 - Sequence 136408 from Patent EP1572962.
JD073654 - Sequence 54678 from Patent EP1572962.
JD409816 - Sequence 390840 from Patent EP1572962.
JD500967 - Sequence 481991 from Patent EP1572962.
JD291318 - Sequence 272342 from Patent EP1572962.
JD528208 - Sequence 509232 from Patent EP1572962.
JD428550 - Sequence 409574 from Patent EP1572962.
JD428551 - Sequence 409575 from Patent EP1572962.
JD234929 - Sequence 215953 from Patent EP1572962.
JD118600 - Sequence 99624 from Patent EP1572962.
JD355282 - Sequence 336306 from Patent EP1572962.
JD541366 - Sequence 522390 from Patent EP1572962.
JD125858 - Sequence 106882 from Patent EP1572962.
JD396424 - Sequence 377448 from Patent EP1572962.
JD119211 - Sequence 100235 from Patent EP1572962.
JD415451 - Sequence 396475 from Patent EP1572962.
JD337295 - Sequence 318319 from Patent EP1572962.
JD203761 - Sequence 184785 from Patent EP1572962.
JD505510 - Sequence 486534 from Patent EP1572962.
JD505511 - Sequence 486535 from Patent EP1572962.
JD332690 - Sequence 313714 from Patent EP1572962.
JD088142 - Sequence 69166 from Patent EP1572962.
JD197523 - Sequence 178547 from Patent EP1572962.
JD234116 - Sequence 215140 from Patent EP1572962.
JD293173 - Sequence 274197 from Patent EP1572962.
JD270485 - Sequence 251509 from Patent EP1572962.
JD209621 - Sequence 190645 from Patent EP1572962.
JD228147 - Sequence 209171 from Patent EP1572962.
JD560822 - Sequence 541846 from Patent EP1572962.
JD288744 - Sequence 269768 from Patent EP1572962.
JD379859 - Sequence 360883 from Patent EP1572962.
JD094315 - Sequence 75339 from Patent EP1572962.
JD084314 - Sequence 65338 from Patent EP1572962.
JD491423 - Sequence 472447 from Patent EP1572962.
JD093298 - Sequence 74322 from Patent EP1572962.
JD318226 - Sequence 299250 from Patent EP1572962.
JD205226 - Sequence 186250 from Patent EP1572962.
JD087163 - Sequence 68187 from Patent EP1572962.
JD262175 - Sequence 243199 from Patent EP1572962.
JD165320 - Sequence 146344 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A9X3Z9, D3DNR3, ENST00000496856.1, ENST00000496856.2, ENST00000496856.3, ENST00000496856.4, ENST00000496856.5, NM_001375804, Q9UID6, uc322stx.1, uc322stx.2, ZASC1, ZN639_HUMAN
UCSC ID: ENST00000496856.6_4
RefSeq Accession: NM_001303426.2
Protein: Q9UID6 (aka ZN639_HUMAN or Z639_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.