Human Gene ZNF641 (ENST00000547026.6_7) from GENCODE V47lift37
  Description: zinc finger protein 641, transcript variant 6 (from RefSeq NM_001365805.1)
Gencode Transcript: ENST00000547026.6_7
Gencode Gene: ENSG00000167528.13_16
Transcript (Including UTRs)
   Position: hg19 chr12:48,730,963-48,744,702 Size: 13,740 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr12:48,736,756-48,741,873 Size: 5,118 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:48,730,963-48,744,702)mRNA (may differ from genome)Protein (424 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN641_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 641;
FUNCTION: Transcriptional activatior. Activates transcriptional activities of SRE and AP-1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle, moderate expression in heart, liver, and pancreas, lower expression in placenta, no expression seen in brain, lung, and kidney.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.38 RPKM in Adrenal Gland
Total median expression: 241.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.50159-0.550 Picture PostScript Text
3' UTR -1690.505793-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q96N77
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK054984 - Homo sapiens cDNA FLJ30422 fis, clone BRACE2008861.
AK127710 - Homo sapiens cDNA FLJ45810 fis, clone NT2RP7014420.
JD488020 - Sequence 469044 from Patent EP1572962.
AL713659 - Homo sapiens mRNA; cDNA DKFZp667D1012 (from clone DKFZp667D1012).
AY842285 - Homo sapiens zinc finger protein 641 (ZNF641) mRNA, complete cds.
JD020195 - Sequence 1219 from Patent EP1572962.
JD028752 - Sequence 9776 from Patent EP1572962.
JD032044 - Sequence 13068 from Patent EP1572962.
JD124313 - Sequence 105337 from Patent EP1572962.
AK055857 - Homo sapiens cDNA FLJ31295 fis, clone KIDNE2007811, weakly similar to ZINC FINGER PROTEIN 202.
AK092740 - Homo sapiens cDNA FLJ35421 fis, clone SMINT2001195, highly similar to Homo sapiens zinc finger protein 641 (ZNF641), mRNA.
AX747699 - Sequence 1224 from Patent EP1308459.
JD349796 - Sequence 330820 from Patent EP1572962.
JD113203 - Sequence 94227 from Patent EP1572962.
JD299398 - Sequence 280422 from Patent EP1572962.
JD374968 - Sequence 355992 from Patent EP1572962.
JD166143 - Sequence 147167 from Patent EP1572962.
AK298064 - Homo sapiens cDNA FLJ58030 complete cds, highly similar to Homo sapiens zinc finger protein 641 (ZNF641), mRNA.
JD239182 - Sequence 220206 from Patent EP1572962.
BC018090 - Homo sapiens zinc finger protein 641, mRNA (cDNA clone MGC:27116 IMAGE:4791876), complete cds.
JD205187 - Sequence 186211 from Patent EP1572962.
JD178163 - Sequence 159187 from Patent EP1572962.
JD051957 - Sequence 32981 from Patent EP1572962.
JD067402 - Sequence 48426 from Patent EP1572962.
AB528974 - Synthetic construct DNA, clone: pF1KE0768, Homo sapiens ZNF641 gene for zinc finger protein 641, without stop codon, in Flexi system.
KJ903686 - Synthetic construct Homo sapiens clone ccsbBroadEn_13080 ZNF641 gene, encodes complete protein.
CU676170 - Synthetic construct Homo sapiens gateway clone IMAGE:100018775 5' read ZNF641 mRNA.
AF086127 - Homo sapiens full length insert cDNA clone ZA79H03.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96N77 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B3KS43, B4DNU5, ENST00000547026.1, ENST00000547026.2, ENST00000547026.3, ENST00000547026.4, ENST00000547026.5, NM_001365805, Q8TCQ7, Q8WVE1, Q96N77, uc324xya.1, uc324xya.2, ZN641_HUMAN
UCSC ID: ENST00000547026.6_7
RefSeq Accession: NM_001172681.2
Protein: Q96N77 (aka ZN641_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.