Human Gene ZNF655 (ENST00000252713.9_11) from GENCODE V47lift37
  Description: zinc finger protein 655, transcript variant 1 (from RefSeq NM_138494.3)
Gencode Transcript: ENST00000252713.9_11
Gencode Gene: ENSG00000197343.11_19
Transcript (Including UTRs)
   Position: hg19 chr7:99,156,265-99,174,076 Size: 17,812 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr7:99,158,183-99,171,207 Size: 13,025 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:99,156,265-99,174,076)mRNA (may differ from genome)Protein (491 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN655_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 655; AltName: Full=Vav-interacting Krueppel-like protein;
FUNCTION: May be involved in transcriptional regulation.
SUBUNIT: Interacts with VAV1 and CDK4.
INTERACTION: P11802:CDK4; NbExp=3; IntAct=EBI-625509, EBI-295644; P15498:VAV1; NbExp=5; IntAct=EBI-625509, EBI-625518;
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 6 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF655
Diseases sorted by gene-association score: ichthyosis, congenital, autosomal recessive 11 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.30 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 720.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.90173-0.427 Picture PostScript Text
3' UTR -788.402869-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - beta-beta-alpha zinc fingers
57802 - Rubredoxin-like
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q8N720
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  KJ899514 - Synthetic construct Homo sapiens clone ccsbBroadEn_08908 ZNF655 gene, encodes complete protein.
BC063478 - Homo sapiens zinc finger protein 655, mRNA (cDNA clone IMAGE:5220152).
AK314593 - Homo sapiens cDNA, FLJ95428, Homo sapiens vav-1 interacting Kruppel-like protein (VIK),transcript variant 1, mRNA.
AY099353 - Homo sapiens vav-1 interacting Kruppel-like protein (VIK) mRNA, complete cds.
AK057245 - Homo sapiens cDNA FLJ32683 fis, clone TESTI2000120, weakly similar to Homo sapiens mRNA for zinc finger 3 (ZF3 gene).
JD408053 - Sequence 389077 from Patent EP1572962.
BC000823 - Homo sapiens zinc finger protein 655, mRNA (cDNA clone IMAGE:3454178), complete cds.
AK225976 - Homo sapiens mRNA for zinc finger protein 655 isoform d variant, clone: FCC112D01.
LF207009 - JP 2014500723-A/14512: Polycomb-Associated Non-Coding RNAs.
BC004288 - Homo sapiens zinc finger protein 655, mRNA (cDNA clone IMAGE:3618410), complete cds.
AK304785 - Homo sapiens cDNA FLJ58468 complete cds, highly similar to Zinc finger protein 655.
BC007378 - Homo sapiens zinc finger protein 655, mRNA (cDNA clone IMAGE:3640530), complete cds.
AK027114 - Homo sapiens cDNA: FLJ23461 fis, clone HSI07757.
AK316024 - Homo sapiens cDNA, FLJ78923 complete cds, highly similar to Zinc finger protein 655.
BC037407 - Homo sapiens zinc finger protein 655, mRNA (cDNA clone MGC:46031 IMAGE:5752559), complete cds.
JD081052 - Sequence 62076 from Patent EP1572962.
KJ906307 - Synthetic construct Homo sapiens clone ccsbBroadEn_15977 ZNF655 gene, encodes complete protein.
CU691494 - Synthetic construct Homo sapiens gateway clone IMAGE:100020707 5' read ZNF655 mRNA.
EU446524 - Synthetic construct Homo sapiens clone IMAGE:100070240; IMAGE:100011733; FLH257298.01L zinc finger protein 655 (ZNF655) gene, encodes complete protein.
AK128057 - Homo sapiens cDNA FLJ46177 fis, clone TESTI4003796, highly similar to Zinc finger protein 655.
CR749270 - Homo sapiens mRNA; cDNA DKFZp686M1631 (from clone DKFZp686M1631).
LF360154 - JP 2014500723-A/167657: Polycomb-Associated Non-Coding RNAs.
BC024770 - Homo sapiens zinc finger protein 655, mRNA (cDNA clone IMAGE:5123283), partial cds.
LF360155 - JP 2014500723-A/167658: Polycomb-Associated Non-Coding RNAs.
BC011816 - Homo sapiens zinc finger protein 655, mRNA (cDNA clone IMAGE:3346747), partial cds.
AK122929 - Homo sapiens cDNA FLJ16616 fis, clone TESTI4013597, highly similar to Zinc finger protein 655.
LF360157 - JP 2014500723-A/167660: Polycomb-Associated Non-Coding RNAs.
LF360158 - JP 2014500723-A/167661: Polycomb-Associated Non-Coding RNAs.
LF360159 - JP 2014500723-A/167662: Polycomb-Associated Non-Coding RNAs.
JD248623 - Sequence 229647 from Patent EP1572962.
JD284984 - Sequence 266008 from Patent EP1572962.
JD440944 - Sequence 421968 from Patent EP1572962.
JD357904 - Sequence 338928 from Patent EP1572962.
AK098231 - Homo sapiens cDNA FLJ40912 fis, clone UTERU2005354.
AK054750 - Homo sapiens cDNA FLJ30188 fis, clone BRACE2001267.
JD300684 - Sequence 281708 from Patent EP1572962.
JD168735 - Sequence 149759 from Patent EP1572962.
JD316911 - Sequence 297935 from Patent EP1572962.
JD295463 - Sequence 276487 from Patent EP1572962.
JD064528 - Sequence 45552 from Patent EP1572962.
JD224970 - Sequence 205994 from Patent EP1572962.
JD064527 - Sequence 45551 from Patent EP1572962.
JD355170 - Sequence 336194 from Patent EP1572962.
JD205315 - Sequence 186339 from Patent EP1572962.
JD159433 - Sequence 140457 from Patent EP1572962.
JD161379 - Sequence 142403 from Patent EP1572962.
JD500983 - Sequence 482007 from Patent EP1572962.
JD566715 - Sequence 547739 from Patent EP1572962.
JD040714 - Sequence 21738 from Patent EP1572962.
JD429523 - Sequence 410547 from Patent EP1572962.
JD092565 - Sequence 73589 from Patent EP1572962.
JD189025 - Sequence 170049 from Patent EP1572962.
JD432201 - Sequence 413225 from Patent EP1572962.
JD312865 - Sequence 293889 from Patent EP1572962.
JD559519 - Sequence 540543 from Patent EP1572962.
JD418574 - Sequence 399598 from Patent EP1572962.
JD299518 - Sequence 280542 from Patent EP1572962.
JD460529 - Sequence 441553 from Patent EP1572962.
JD432541 - Sequence 413565 from Patent EP1572962.
JD432542 - Sequence 413566 from Patent EP1572962.
JD143475 - Sequence 124499 from Patent EP1572962.
JD417686 - Sequence 398710 from Patent EP1572962.
JD411935 - Sequence 392959 from Patent EP1572962.
JD514910 - Sequence 495934 from Patent EP1572962.
JD421446 - Sequence 402470 from Patent EP1572962.
JD179064 - Sequence 160088 from Patent EP1572962.
JD517674 - Sequence 498698 from Patent EP1572962.
JD069080 - Sequence 50104 from Patent EP1572962.
JD549394 - Sequence 530418 from Patent EP1572962.
LF360160 - JP 2014500723-A/167663: Polycomb-Associated Non-Coding RNAs.
JD531070 - Sequence 512094 from Patent EP1572962.
JD375026 - Sequence 356050 from Patent EP1572962.
JD356749 - Sequence 337773 from Patent EP1572962.
JD044029 - Sequence 25053 from Patent EP1572962.
JD291667 - Sequence 272691 from Patent EP1572962.
JD156858 - Sequence 137882 from Patent EP1572962.
JD116766 - Sequence 97790 from Patent EP1572962.
AF086023 - Homo sapiens full length insert cDNA clone YW23E08.
MA442586 - JP 2018138019-A/14512: Polycomb-Associated Non-Coding RNAs.
MA595731 - JP 2018138019-A/167657: Polycomb-Associated Non-Coding RNAs.
MA595732 - JP 2018138019-A/167658: Polycomb-Associated Non-Coding RNAs.
MA595734 - JP 2018138019-A/167660: Polycomb-Associated Non-Coding RNAs.
MA595735 - JP 2018138019-A/167661: Polycomb-Associated Non-Coding RNAs.
MA595736 - JP 2018138019-A/167662: Polycomb-Associated Non-Coding RNAs.
MA595737 - JP 2018138019-A/167663: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N720 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A4D291, A6NGD3, B4E3M4, B7Z9Q9, D6W5T4, ENST00000252713.1, ENST00000252713.2, ENST00000252713.3, ENST00000252713.4, ENST00000252713.5, ENST00000252713.6, ENST00000252713.7, ENST00000252713.8, NM_138494, Q8IV00, Q8N720, Q8TA89, Q96EZ3, Q9BQ85, uc317fii.1, uc317fii.2, VIK, ZN655_HUMAN
UCSC ID: ENST00000252713.9_11
RefSeq Accession: NM_138494.3
Protein: Q8N720 (aka ZN655_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.