Human Gene ZNF670 (ENST00000366503.3_7) from GENCODE V47lift37
  Description: zinc finger protein 670, transcript variant 1 (from RefSeq NM_033213.5)
Gencode Transcript: ENST00000366503.3_7
Gencode Gene: ENSG00000277462.2_10
Transcript (Including UTRs)
   Position: hg19 chr1:247,197,939-247,242,113 Size: 44,175 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:247,200,751-247,241,898 Size: 41,148 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:247,197,939-247,242,113)mRNA (may differ from genome)Protein (389 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN670_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 670;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 9 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF670
Diseases sorted by gene-association score: vitreous disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.18 RPKM in Testis
Total median expression: 49.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.10215-0.484 Picture PostScript Text
3' UTR -701.302812-0.249 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q9BS34
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK126366 - Homo sapiens cDNA FLJ44402 fis, clone TUTER2000425, moderately similar to Zinc finger protein 695.
AK074774 - Homo sapiens cDNA FLJ90293 fis, clone NT2RP2000092, moderately similar to ZINC FINGER PROTEIN 136.
BC005360 - Homo sapiens zinc finger protein 670, mRNA (cDNA clone MGC:12466 IMAGE:3684736), complete cds.
KJ895209 - Synthetic construct Homo sapiens clone ccsbBroadEn_04603 ZNF670 gene, encodes complete protein.
EU446560 - Synthetic construct Homo sapiens clone IMAGE:100070030; IMAGE:100011769; FLH257383.01L zinc finger protein 670 (ZNF670) gene, encodes complete protein.
AB587529 - Synthetic construct DNA, clone: pF1KE0660, Homo sapiens ZNF670 gene for zinc finger protein 670, without stop codon, in Flexi system.
CU675141 - Synthetic construct Homo sapiens gateway clone IMAGE:100019203 5' read ZNF670 mRNA.
AK027325 - Homo sapiens cDNA FLJ14419 fis, clone HEMBA1005572.
JD212246 - Sequence 193270 from Patent EP1572962.
JD432392 - Sequence 413416 from Patent EP1572962.
JD197328 - Sequence 178352 from Patent EP1572962.
JD492570 - Sequence 473594 from Patent EP1572962.
JD546709 - Sequence 527733 from Patent EP1572962.
JD280086 - Sequence 261110 from Patent EP1572962.
JD442011 - Sequence 423035 from Patent EP1572962.
JD049252 - Sequence 30276 from Patent EP1572962.
JD301560 - Sequence 282584 from Patent EP1572962.
JD490517 - Sequence 471541 from Patent EP1572962.
JD032199 - Sequence 13223 from Patent EP1572962.
JD365462 - Sequence 346486 from Patent EP1572962.
JD226603 - Sequence 207627 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BS34 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000366503.1, ENST00000366503.2, NM_033213, Q9BS34, uc318fdb.1, uc318fdb.2, ZN670_HUMAN
UCSC ID: ENST00000366503.3_7
RefSeq Accession: NM_033213.5
Protein: Q9BS34 (aka ZN670_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.