Human Gene ZNF785 (ENST00000395216.3_9) from GENCODE V47lift37
  Description: zinc finger protein 785 (from RefSeq NM_152458.7)
Gencode Transcript: ENST00000395216.3_9
Gencode Gene: ENSG00000197162.10_13
Transcript (Including UTRs)
   Position: hg19 chr16:30,591,977-30,597,018 Size: 5,042 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr16:30,593,881-30,596,932 Size: 3,052 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:30,591,977-30,597,018)mRNA (may differ from genome)Protein (405 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN785_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 785;
FUNCTION: May be involved in transcriptional regulation (By similarity).
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 7 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.29 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 158.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.3086-0.294 Picture PostScript Text
3' UTR -775.201904-0.407 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on A8K8V0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK056692 - Homo sapiens cDNA FLJ32130 fis, clone PEBLM2000248, weakly similar to ZINC FINGER PROTEIN 157.
AK298848 - Homo sapiens cDNA FLJ51514 complete cds, highly similar to Zinc finger protein 688.
AK292465 - Homo sapiens cDNA FLJ75041 complete cds.
AK309511 - Homo sapiens cDNA, FLJ99552.
BC040642 - Homo sapiens zinc finger protein 785, mRNA (cDNA clone MGC:41915 IMAGE:4811661), complete cds.
JD220441 - Sequence 201465 from Patent EP1572962.
JD432490 - Sequence 413514 from Patent EP1572962.
JD247017 - Sequence 228041 from Patent EP1572962.
JD413445 - Sequence 394469 from Patent EP1572962.
JD198140 - Sequence 179164 from Patent EP1572962.
JD212745 - Sequence 193769 from Patent EP1572962.
JD089984 - Sequence 71008 from Patent EP1572962.
JD257147 - Sequence 238171 from Patent EP1572962.
JD408491 - Sequence 389515 from Patent EP1572962.
JD420411 - Sequence 401435 from Patent EP1572962.
JD074138 - Sequence 55162 from Patent EP1572962.
JD364332 - Sequence 345356 from Patent EP1572962.
JD318776 - Sequence 299800 from Patent EP1572962.
JD115463 - Sequence 96487 from Patent EP1572962.
JD276053 - Sequence 257077 from Patent EP1572962.
JD425994 - Sequence 407018 from Patent EP1572962.
JD293856 - Sequence 274880 from Patent EP1572962.
JD428448 - Sequence 409472 from Patent EP1572962.
JD234313 - Sequence 215337 from Patent EP1572962.
JD234312 - Sequence 215336 from Patent EP1572962.
JD550419 - Sequence 531443 from Patent EP1572962.
JD293855 - Sequence 274879 from Patent EP1572962.
JD294394 - Sequence 275418 from Patent EP1572962.
JD138786 - Sequence 119810 from Patent EP1572962.
JD361528 - Sequence 342552 from Patent EP1572962.
JD504427 - Sequence 485451 from Patent EP1572962.
JD313750 - Sequence 294774 from Patent EP1572962.
JD081644 - Sequence 62668 from Patent EP1572962.
JD222396 - Sequence 203420 from Patent EP1572962.
JD081645 - Sequence 62669 from Patent EP1572962.
JD211637 - Sequence 192661 from Patent EP1572962.
JD256701 - Sequence 237725 from Patent EP1572962.
JD071371 - Sequence 52395 from Patent EP1572962.
JD310105 - Sequence 291129 from Patent EP1572962.
JD531629 - Sequence 512653 from Patent EP1572962.
JD088889 - Sequence 69913 from Patent EP1572962.
JD214123 - Sequence 195147 from Patent EP1572962.
JD119985 - Sequence 101009 from Patent EP1572962.
JD122954 - Sequence 103978 from Patent EP1572962.
JD467383 - Sequence 448407 from Patent EP1572962.
JD451011 - Sequence 432035 from Patent EP1572962.
JD485415 - Sequence 466439 from Patent EP1572962.
JD157904 - Sequence 138928 from Patent EP1572962.
JD393065 - Sequence 374089 from Patent EP1572962.
KJ895597 - Synthetic construct Homo sapiens clone ccsbBroadEn_04991 ZNF785 gene, encodes complete protein.
EU446576 - Synthetic construct Homo sapiens clone IMAGE:100070277; IMAGE:100011785; FLH257255.01L zinc finger protein 785 (ZNF785) gene, encodes complete protein.
CU691912 - Synthetic construct Homo sapiens gateway clone IMAGE:100020923 5' read ZNF785 mRNA.
JD370834 - Sequence 351858 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein A8K8V0 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8V0, ENST00000395216.1, ENST00000395216.2, NM_152458, O75701, Q8IW91, Q8WV14, Q96MN0, uc318xgc.1, uc318xgc.2, ZN785_HUMAN
UCSC ID: ENST00000395216.3_9
RefSeq Accession: NM_152458.7
Protein: A8K8V0 (aka ZN785_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.