Human Gene ZNF835 (ENST00000537055.4_7) from GENCODE V47lift37
  Description: zinc finger protein 835 (from RefSeq NM_001005850.3)
Gencode Transcript: ENST00000537055.4_7
Gencode Gene: ENSG00000127903.14_10
Transcript (Including UTRs)
   Position: hg19 chr19:57,173,348-57,183,125 Size: 9,778 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr19:57,174,953-57,176,566 Size: 1,614 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:57,173,348-57,183,125)mRNA (may differ from genome)Protein (537 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN835_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 835;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 14 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAD23609.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.24 RPKM in Brain - Cerebellum
Total median expression: 50.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.00229-0.341 Picture PostScript Text
3' UTR -547.601605-0.341 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF04565 - RNA polymerase Rpb2, domain 3

SCOP Domains:
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
82919 - Zn-finger domain of Sec23/24
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q9Y2P0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LP896147 - Sequence 1011 from Patent EP3253886.
AK023017 - Homo sapiens cDNA FLJ12955 fis, clone NT2RP2005496, moderately similar to ZINC FINGER PROTEIN 135.
JD447448 - Sequence 428472 from Patent EP1572962.
JD120568 - Sequence 101592 from Patent EP1572962.
JD085760 - Sequence 66784 from Patent EP1572962.
JD311803 - Sequence 292827 from Patent EP1572962.
JD560468 - Sequence 541492 from Patent EP1572962.
JD503481 - Sequence 484505 from Patent EP1572962.
JD108133 - Sequence 89157 from Patent EP1572962.
JD242943 - Sequence 223967 from Patent EP1572962.
JD265538 - Sequence 246562 from Patent EP1572962.
JD254818 - Sequence 235842 from Patent EP1572962.
JD074139 - Sequence 55163 from Patent EP1572962.
JD065878 - Sequence 46902 from Patent EP1572962.
JD242951 - Sequence 223975 from Patent EP1572962.
JD242950 - Sequence 223974 from Patent EP1572962.
JD396188 - Sequence 377212 from Patent EP1572962.
JD519113 - Sequence 500137 from Patent EP1572962.
JD489196 - Sequence 470220 from Patent EP1572962.
JD409300 - Sequence 390324 from Patent EP1572962.
JD523044 - Sequence 504068 from Patent EP1572962.
JD306816 - Sequence 287840 from Patent EP1572962.
JD519097 - Sequence 500121 from Patent EP1572962.
JD212890 - Sequence 193914 from Patent EP1572962.
JD407502 - Sequence 388526 from Patent EP1572962.
JD152186 - Sequence 133210 from Patent EP1572962.
JD526239 - Sequence 507263 from Patent EP1572962.
JD352923 - Sequence 333947 from Patent EP1572962.
AK299565 - Homo sapiens cDNA FLJ54874 complete cds, moderately similar to Zinc finger protein 135.
JD513479 - Sequence 494503 from Patent EP1572962.
JD050597 - Sequence 31621 from Patent EP1572962.
JD097306 - Sequence 78330 from Patent EP1572962.
JD293829 - Sequence 274853 from Patent EP1572962.
JD076718 - Sequence 57742 from Patent EP1572962.
JD370327 - Sequence 351351 from Patent EP1572962.
JD265142 - Sequence 246166 from Patent EP1572962.
JD371477 - Sequence 352501 from Patent EP1572962.
JD210726 - Sequence 191750 from Patent EP1572962.
JD129355 - Sequence 110379 from Patent EP1572962.
JD458651 - Sequence 439675 from Patent EP1572962.
JD462139 - Sequence 443163 from Patent EP1572962.
JD336667 - Sequence 317691 from Patent EP1572962.
JD461218 - Sequence 442242 from Patent EP1572962.
JD382979 - Sequence 364003 from Patent EP1572962.
JD201092 - Sequence 182116 from Patent EP1572962.
JD382979 - Sequence 364003 from Patent EP1572962.
JD483953 - Sequence 464977 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B7Z5Y0, ENST00000537055.1, ENST00000537055.2, ENST00000537055.3, G3V1S0, NM_001005850, Q9Y2P0, uc324phk.1, uc324phk.2, ZN835_HUMAN
UCSC ID: ENST00000537055.4_7
RefSeq Accession: NM_001005850.3
Protein: Q9Y2P0 (aka ZN835_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.