Human Gene ZNHIT2 (ENST00000310597.6_6) from GENCODE V47lift37
  Description: zinc finger HIT-type containing 2 (from RefSeq NM_014205.4)
Gencode Transcript: ENST00000310597.6_6
Gencode Gene: ENSG00000174276.7_9
Transcript (Including UTRs)
   Position: hg19 chr11:64,883,875-64,885,173 Size: 1,299 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr11:64,883,914-64,885,125 Size: 1,212 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:64,883,875-64,885,173)mRNA (may differ from genome)Protein (403 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNHI2_HUMAN
DESCRIPTION: RecName: Full=Zinc finger HIT domain-containing protein 2; AltName: Full=Protein FON;
TISSUE SPECIFICITY: Low expression in most tissues; highly expressed in testis.
SIMILARITY: Contains 1 HIT-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNHIT2
Diseases sorted by gene-association score: triple-receptor negative breast cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 70.28 RPKM in Testis
Total median expression: 387.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.4048-0.300 Picture PostScript Text
3' UTR -8.7039-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007529 - Znf_HIT

Pfam Domains:
PF04438 - HIT zinc finger

SCOP Domains:
144232 - HIT/MYND zinc finger-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1X4S - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9UHR6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:0022008 neurogenesis


-  Descriptions from all associated GenBank mRNAs
  AK223333 - Homo sapiens mRNA for zinc finger, HIT domain containing 2 variant, clone: TST01476.
BC041076 - Homo sapiens zinc finger, HIT type 2, mRNA (cDNA clone IMAGE:5924405).
AK027081 - Homo sapiens cDNA: FLJ23428 fis, clone HRC06772, highly similar to AF119497 Homo sapiens C11orf5 (FON) mRNA.
AF119497 - Homo sapiens C11orf5 (FON) mRNA, complete cds.
BC052240 - Homo sapiens zinc finger, HIT type 2, mRNA (cDNA clone MGC:59789 IMAGE:6107352), complete cds.
AK223358 - Homo sapiens mRNA for zinc finger, HIT domain containing 2 variant, clone: TST08617.
BC057799 - Homo sapiens zinc finger, HIT type 2, mRNA (cDNA clone IMAGE:30339140), with apparent retained intron.
KJ896524 - Synthetic construct Homo sapiens clone ccsbBroadEn_05918 ZNHIT2 gene, encodes complete protein.
BC029825 - Homo sapiens zinc finger, HIT type 2, mRNA (cDNA clone IMAGE:5176182), partial cds.
BC038089 - Homo sapiens zinc finger, HIT type 2, mRNA (cDNA clone IMAGE:5220642), partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: C11orf5, ENST00000310597.1, ENST00000310597.2, ENST00000310597.3, ENST00000310597.4, ENST00000310597.5, NM_014205, Q3SY14, Q8IUV0, Q9UHR6, uc317ouh.1, uc317ouh.2, ZNHI2_HUMAN
UCSC ID: ENST00000310597.6_6
RefSeq Accession: NM_014205.4
Protein: Q9UHR6 (aka ZNHI2_HUMAN or ZNH2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.