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J Immunol 2005, PMID: 16116184

Galectin-9 induces maturation of human monocyte-derived dendritic cells.

Dai, Shu-Yan; Nakagawa, Ryusuke; Itoh, Aiko; Murakami, Hiromoto; Kashio, Yumiko; Abe, Hiroko; Katoh, Shigeki; Kontani, Keiichi; Kihara, Minoru; Zhang, Shu-Lan; Hata, Toshiyuki; Nakamura, Takanori; Yamauchi, Akira; Hirashima, Mitsuomi

Maturation of dendritic cells (DCs) is critical for initiation of immune responses and is regulated by various stimulatory signals. We assessed the role of galectin (Gal)-9 in DC maturation. Culture of immature DCs with exogenous Gal-9 markedly increased the surface expression of CD40, CD54, CD80, CD83, CD86, and HLA-DR in a dose-dependent manner, although Gal-9 had no or little effect on differentiation of human monocytes into immature DCs. Gal-9-treated DCs secreted IL-12 but not IL-10, and they elicited the production of Th1 cytokines (IFN-gamma and IL-2) but not that of the Th2 cytokines (IL-4 and IL-5) by allogeneic CD4+ T cells. These effects of Gal-9 on immature DCs were not essentially dependent on its lectin properties, given that they were inhibited only slightly by lactose. We further found that a Gal-9 mutant that lacks beta-galactoside binding activity reproduced the above activities and that an anti-Gal-9 mAb suppressed them. Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9-induced up-regulation of costimulatory molecule expression and IL-12 production. These findings suggest that Gal-9 plays a role not only in innate immunity but also in acquired immunity by inducing DC maturation and promoting Th1 immune responses.

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Text Mining Data

DCs — Gal-9: " These effects of Gal-9 on immature DCs were not essentially dependent on its lectin properties, given that they were inhibited only slightly by lactose "

costimulatory molecule ⊣ Gal-9: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

IL-12 ⊣ Gal-9: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

DCs → p38: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs , and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

DCs → Gal-9: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs , and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

costimulatory molecule → p38: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

ERK1/2 → p38: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

ERK1/2 → Gal-9: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

p38 → Gal-9: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

IL-12 → p38: " Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production "

Manually curated Databases

No curated data.