Gene interactions and pathways from curated databases and text-mining
Cell 2009, PMID: 19410545

HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.

Dunleavy, Elaine M; Roche, Danièle; Tagami, Hideaki; Lacoste, Nicolas; Ray-Gallet, Dominique; Nakamura, Yusuke; Daigo, Yataro; Nakatani, Yoshihiro; Almouzni-Pettinotti, Geneviève

The histone H3 variant CenH3, called CENP-A in humans, is central in centromeric chromatin to ensure proper chromosome segregation. In the absence of an underlying DNA sequence, it is still unclear how CENP-A deposition at centromeres is determined. Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified HJURP. HJURP was not detected in H3.1- or H3.3-containing complexes, indicating its specificity for CENP-A. HJURP centromeric localization is cell cycle regulated, and its transient appearance at the centromere coincides precisely with the proposed time window for new CENP-A deposition. Furthermore, HJURP downregulation leads to a major reduction in CENP-A at centromeres and impairs deposition of newly synthesized CENP-A, causing mitotic defects. We conclude that HJURP is a key factor for CENP-A deposition and maintenance at centromeres.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: CENPA — HJURP (direct interaction, pull down)
  • IRef Biogrid Interaction: CENPA — HJURP (physical association, affinity chromatography technology)
  • IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: CENPA — HJURP (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: CENPA — HJURP (physical association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: CENPA — HJURP (physical association, pull down)
  • IRef Intact Interaction: CENPA — HJURP (colocalization, confocal microscopy)
  • IRef Intact Interaction: Complex of RBBP4-HJURP-HJURP-RBBP4-NPM1-CENPA-NPM1-CENPA (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: Complex of HIRA-H3F3A-RBBP4 (association, anti tag coimmunoprecipitation)
  • Reactome Reaction: CENPI → RUVBL1 (reaction)
  • Reactome Reaction: RBBP7 → RUVBL1 (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPU (reaction)
  • Reactome Reaction: CENPA → CENPP (reaction)
  • Reactome Reaction: RUVBL1 → CENPN (reaction)
  • Reactome Reaction: RBBP7 → CASC5 (indirect_complex)
  • Reactome Reaction: CENPA → MIS18A (indirect_complex)
  • Reactome Reaction: CENPK → HJURP (reaction)
  • Reactome Reaction: OIP5 → RBBP4 (reaction)
  • Reactome Reaction: HJURP → HIST1H4A (indirect_complex)
  • Reactome Reaction: CENPU → HJURP (reaction)
  • Reactome Reaction: MIS18A → NPM1 (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPU (reaction)
  • Reactome Reaction: CENPN → HIST1H4A (reaction)
  • Reactome Reaction: RBBP4 → CENPU (indirect_complex)
  • Reactome Reaction: CENPU → HIST1H4A (reaction)
  • Reactome Reaction: HJURP → ITGB3BP (indirect_complex)
  • Reactome Reaction: MIS18BP1 → NPM1 (reaction)
  • Reactome Reaction: RUVBL1 → ITGB3BP (reaction)
  • Reactome Reaction: RBBP4 → ITGB3BP (reaction)
  • Reactome Reaction: RUVBL1 → CENPQ (indirect_complex)
  • Reactome Reaction: CASC5 → HIST1H4A (reaction)
  • Reactome Reaction: MIS18A → CENPQ (indirect_complex)
  • Reactome Reaction: OIP5 → CENPP (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPN (reaction)
  • Reactome Reaction: MIS18A → HJURP (indirect_complex)
  • Reactome Reaction: MIS18A → HJURP (reaction)
  • Reactome Reaction: CENPA → MIS18BP1 (indirect_complex)
  • Reactome Reaction: RUVBL1 → ITGB3BP (indirect_complex)
  • Reactome Reaction: RBBP4 → ITGB3BP (indirect_complex)
  • Reactome Reaction: CENPK → NPM1 (indirect_complex)
  • Reactome Reaction: CENPU → NPM1 (indirect_complex)
  • Reactome Reaction: CENPH → NPM1 (reaction)
  • Reactome Reaction: RBBP4 → CENPO (indirect_complex)
  • Reactome Reaction: CENPN → NPM1 (reaction)
  • Reactome Reaction: CASC5 → MIS18BP1 (indirect_complex)
  • Reactome Reaction: CENPQ → NPM1 (reaction)
  • Reactome Reaction: RBBP4 → NPM1 (reaction)
  • Reactome Reaction: RBBP4 → MIS18BP1 (reaction)
  • Reactome Reaction: CENPO → NPM1 (indirect_complex)
  • Reactome Reaction: CENPQ → MIS18BP1 (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPQ (reaction)
  • Reactome Reaction: RUVBL1 → CENPP (indirect_complex)
  • Reactome Reaction: CASC5 → NPM1 (reaction)
  • Reactome Reaction: CENPU → MIS18BP1 (indirect_complex)
  • Reactome Reaction: OIP5 → ITGB3BP (indirect_complex)
  • Reactome Reaction: CENPI → HJURP (indirect_complex)
  • Reactome Reaction: CENPI → MIS18BP1 (indirect_complex)
  • Reactome Reaction: CENPQ → HIST1H4A (reaction)
  • Reactome Reaction: CENPK → HIST1H4A (reaction)
  • Reactome Reaction: CENPO → HIST1H4A (reaction)
  • Reactome Reaction: OIP5 → CENPN (indirect_complex)
  • Reactome Reaction: CENPQ → HJURP (reaction)
  • Reactome Reaction: OIP5 → RUVBL1 (indirect_complex)
  • Reactome Reaction: MIS18A → RUVBL1 (reaction)
  • Reactome Reaction: RUVBL1 → CENPU (indirect_complex)
  • Reactome Reaction: HIST1H4A → ITGB3BP (indirect_complex)
  • Reactome Reaction: CENPA → CENPP (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPP (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPK (reaction)
  • Reactome Reaction: MIS18A → CENPN (indirect_complex)
  • Reactome Reaction: CENPN → NPM1 (indirect_complex)
  • Reactome Reaction: CENPA → RBBP4 (indirect_complex)
  • Reactome Reaction: MIS18A → RBBP4 (indirect_complex)
  • Reactome Reaction: RBBP7 → RUVBL1 (reaction)
  • Reactome Reaction: CASC5 → HIST1H4A (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPH (indirect_complex)
  • Reactome Reaction: CENPO → HJURP (reaction)
  • Reactome Reaction: OIP5 → NPM1 (indirect_complex)
  • Reactome Reaction: NPM1 → ITGB3BP (reaction)
  • Reactome Reaction: CENPI → HJURP (reaction)
  • Reactome Reaction: CENPI → RUVBL1 (indirect_complex)
  • Reactome Reaction: CASC5 → NPM1 (indirect_complex)
  • Reactome Reaction: RBBP4 → RBBP7 (reaction)
  • Reactome Reaction: CENPP → HJURP (reaction)
  • Reactome Reaction: CENPA → CENPN (indirect_complex)
  • Reactome Reaction: CENPI → RBBP7 (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPH (reaction)
  • Reactome Reaction: RBBP7 → CENPU (indirect_complex)
  • Reactome Reaction: CENPA → OIP5 (reaction)
  • Reactome Reaction: CENPK → MIS18BP1 (indirect_complex)
  • Reactome Reaction: CENPA → CASC5 (indirect_complex)
  • Reactome Reaction: CENPK → NPM1 (reaction)
  • Reactome Reaction: RUVBL1 → CASC5 (reaction)
  • Reactome Reaction: MIS18BP1 → HIST1H4A (indirect_complex)
  • Reactome Reaction: CENPP → HIST1H4A (reaction)
  • Reactome Reaction: CASC5 → HJURP (reaction)
  • Reactome Reaction: MIS18BP1 → NPM1 (indirect_complex)
  • Reactome Reaction: CENPN → HJURP (indirect_complex)
  • Reactome Reaction: CENPH → NPM1 (indirect_complex)
  • Reactome Reaction: CENPA → MIS18A (reaction)
  • Reactome Reaction: OIP5 → NPM1 (reaction)
  • Reactome Reaction: CENPO → MIS18BP1 (indirect_complex)
  • Reactome Reaction: CENPP → HIST1H4A (indirect_complex)
  • Reactome Reaction: CENPP → HJURP (indirect_complex)
  • Reactome Reaction: RBBP4 → RBBP4 (reaction)
  • Reactome Reaction: CENPO → NPM1 (reaction)
  • Reactome Reaction: RUVBL1 → CENPN (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPO (reaction)
  • Reactome Reaction: RBBP4 → HJURP (reaction)
  • Reactome Reaction: CENPK → HIST1H4A (indirect_complex)
  • Reactome Reaction: RBBP7 → CENPO (indirect_complex)
  • Reactome Reaction: OIP5 → CENPU (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPK (reaction)
  • Reactome Reaction: CENPI → NPM1 (reaction)
  • Reactome Reaction: CENPA → CENPU (reaction)
  • Reactome Reaction: CENPA → CENPN (reaction)
  • Reactome Reaction: RBBP7 → CENPN (indirect_complex)
  • Reactome Reaction: MIS18A → CENPH (indirect_complex)
  • Reactome Reaction: CENPA → OIP5 (indirect_complex)
  • Reactome Reaction: MIS18BP1 → ITGB3BP (indirect_complex)
  • Reactome Reaction: OIP5 → RBBP4 (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPO (reaction)
  • Reactome Reaction: CENPK → HJURP (indirect_complex)
  • Reactome Reaction: MIS18A → NPM1 (reaction)
  • Reactome Reaction: MIS18BP1 → HIST1H4A (reaction)
  • Reactome Reaction: RBBP7 → NPM1 (reaction)
  • Reactome Reaction: CENPA → CENPO (reaction)
  • Reactome Reaction: CENPI → HIST1H4A (reaction)
  • Reactome Reaction: OIP5 → HIST1H4A (reaction)
  • Reactome Reaction: RBBP7 → HJURP (reaction)
  • Reactome Reaction: RBBP7 → HIST1H4A (indirect_complex)
  • Reactome Reaction: RBBP4 → MIS18BP1 (indirect_complex)
  • Reactome Reaction: RUVBL1 → CASC5 (indirect_complex)
  • Reactome Reaction: CENPA → NPM1 (indirect_complex)
  • Reactome Reaction: CENPA → RBBP7 (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPK (indirect_complex)
  • Reactome Reaction: CENPA → ITGB3BP (indirect_complex)
  • Reactome Reaction: MIS18A → HIST1H4A (reaction)
  • Reactome Reaction: CENPP → NPM1 (reaction)
  • Reactome Reaction: CENPA → CENPI (reaction)
  • Reactome Reaction: CENPH → HJURP (indirect_complex)
  • Reactome Reaction: CENPU → NPM1 (reaction)
  • Reactome Reaction: CENPQ → HJURP (indirect_complex)
  • Reactome Reaction: MIS18BP1 → HJURP (indirect_complex)
  • Reactome Reaction: RBBP7 → CENPH (indirect_complex)
  • Reactome Reaction: RBBP4 → HJURP (indirect_complex)
  • Reactome Reaction: MIS18A → CENPP (indirect_complex)
  • Reactome Reaction: CENPA → RBBP7 (reaction)
  • Reactome Reaction: RBBP4 → CENPP (reaction)
  • Reactome Reaction: CENPO → HIST1H4A (indirect_complex)
  • Reactome Reaction: OIP5 → CENPO (indirect_complex)
  • Reactome Reaction: CENPA → CASC5 (reaction)
  • Reactome Reaction: CENPH → HJURP (reaction)
  • Reactome Reaction: RBBP4 → CENPQ (reaction)
  • Reactome Reaction: RUVBL1 → CENPP (reaction)
  • Reactome Reaction: RBBP7 → CENPQ (indirect_complex)
  • Reactome Reaction: RUVBL1 → HIST1H4A (indirect_complex)
  • Reactome Reaction: CENPP → NPM1 (indirect_complex)
  • Reactome Reaction: CENPI → HIST1H4A (indirect_complex)
  • Reactome Reaction: CENPN → HIST1H4A (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPN (indirect_complex)
  • Reactome Reaction: RBBP4 → CASC5 (reaction)
  • Reactome Reaction: CENPA → CENPK (reaction)
  • Reactome Reaction: RBBP7 → NPM1 (indirect_complex)
  • Reactome Reaction: CENPO → HJURP (indirect_complex)
  • Reactome Reaction: RBBP4 → HIST1H4A (reaction)
  • Reactome Reaction: RBBP4 → NPM1 (indirect_complex)
  • Reactome Reaction: CENPU → HIST1H4A (indirect_complex)
  • Reactome Reaction: RUVBL1 → MIS18BP1 (indirect_complex)
  • Reactome Reaction: CENPH → MIS18BP1 (indirect_complex)
  • Reactome Reaction: NPM1 → ITGB3BP (indirect_complex)
  • Reactome Reaction: CENPA → CENPH (indirect_complex)
  • Reactome Reaction: CENPA → CENPH (reaction)
  • Reactome Reaction: CENPA → CENPK (indirect_complex)
  • Reactome Reaction: CENPA → CENPO (indirect_complex)
  • Reactome Reaction: RBBP7 → ITGB3BP (indirect_complex)
  • Reactome Reaction: CENPA → ITGB3BP (reaction)
  • Reactome Reaction: CENPA → HJURP (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPO (indirect_complex)
  • Reactome Reaction: CENPN → MIS18BP1 (indirect_complex)
  • Reactome Reaction: CENPA → CENPU (indirect_complex)
  • Reactome Reaction: HIST1H4A → NPM1 (indirect_complex)
  • Reactome Reaction: CENPN → HJURP (reaction)
  • Reactome Reaction: CENPU → HJURP (indirect_complex)
  • Reactome Reaction: RBBP7 → HJURP (indirect_complex)
  • Reactome Reaction: RUVBL1 → MIS18BP1 (reaction)
  • Reactome Reaction: RBBP4 → CENPQ (indirect_complex)
  • Reactome Reaction: MIS18A → ITGB3BP (indirect_complex)
  • Reactome Reaction: CENPQ → NPM1 (indirect_complex)
  • Reactome Reaction: RBBP4 → RUVBL1 (indirect_complex)
  • Reactome Reaction: MIS18A → CENPK (indirect_complex)
  • Reactome Reaction: MIS18A → CASC5 (indirect_complex)
  • Reactome Reaction: CASC5 → HJURP (indirect_complex)
  • Reactome Reaction: CENPA → RUVBL1 (indirect_complex)
  • Reactome Reaction: RUVBL1 → CENPH (reaction)
  • Reactome Reaction: MIS18A → HIST1H4A (indirect_complex)
  • Reactome Reaction: RBBP4 → RUVBL1 (reaction)
  • Reactome Reaction: CENPI → RBBP4 (reaction)
  • Reactome Reaction: CENPA → CENPQ (reaction)
  • Reactome Reaction: RBBP7 → CENPK (indirect_complex)
  • Reactome Reaction: OIP5 → RUVBL1 (reaction)
  • Reactome Reaction: MIS18A → RUVBL1 (indirect_complex)
  • Reactome Reaction: CENPA → CENPI (indirect_complex)
  • Reactome Reaction: RBBP4 → CENPH (indirect_complex)
  • Reactome Reaction: CENPI → NPM1 (indirect_complex)
  • Reactome Reaction: OIP5 → CASC5 (indirect_complex)
  • Reactome Reaction: CENPP → MIS18BP1 (indirect_complex)
  • Reactome Reaction: CENPA → MIS18BP1 (reaction)
  • Reactome Reaction: RBBP4 → CENPK (indirect_complex)
  • Reactome Reaction: CENPQ → HIST1H4A (indirect_complex)
  • Reactome Reaction: HIST1H4A → ITGB3BP (reaction)
  • Reactome Reaction: OIP5 → HJURP (reaction)
  • Reactome Reaction: OIP5 → CENPK (indirect_complex)
  • Reactome Reaction: RBBP7 → CENPP (indirect_complex)
  • Reactome Reaction: MIS18A → CENPO (indirect_complex)
  • Reactome Reaction: RBBP7 → HIST1H4A (reaction)
  • Reactome Reaction: RBBP4 → CASC5 (indirect_complex)
  • Reactome Reaction: OIP5 → HJURP (indirect_complex)
  • Reactome Reaction: CENPI → RBBP4 (indirect_complex)
  • Reactome Reaction: CENPA → RBBP4 (reaction)
  • Reactome Reaction: RBBP4 → HIST1H4A (indirect_complex)
  • Reactome Reaction: HJURP → ITGB3BP (reaction)
  • Reactome Reaction: CENPI → OIP5 (indirect_complex)
  • Reactome Reaction: CENPA → CENPQ (indirect_complex)
  • Reactome Reaction: OIP5 → HIST1H4A (indirect_complex)
  • Reactome Reaction: RBBP4 → RBBP7 (indirect_complex)
  • Reactome Reaction: OIP5 → CENPH (indirect_complex)
  • Reactome Reaction: OIP5 → CENPQ (indirect_complex)
  • Reactome Reaction: MIS18A → CENPI (indirect_complex)
  • Reactome Reaction: CENPH → HIST1H4A (indirect_complex)
  • Reactome Reaction: MIS18A → CENPU (indirect_complex)
  • Reactome Reaction: MIS18BP1 → HJURP (reaction)
  • Reactome Reaction: CENPH → HIST1H4A (reaction)
  • Reactome Reaction: MIS18A → RBBP4 (reaction)
In total, 218 gene pairs are associated to this article in curated databases