Gene interactions and pathways from curated databases and text-mining
Genes Dev 2013, PMID: 23322298

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Davis, Michael A; Larimore, Elizabeth A; Fissel, Brian M; Swanger, Jherek; Taatjes, Dylan J; Clurman, Bruce E

The Mediator complex is an essential transcription regulator that bridges transcription factors with RNA polymerase II. This interaction is controlled by dynamic interactions between Mediator and the CDK8 module, but the mechanisms governing CDK8 module-Mediator association remain poorly understood. We show that Fbw7, a tumor suppressor and ubiquitin ligase, binds to CDK8-Mediator and targets MED13/13L for degradation. MED13/13L physically link the CDK8 module to Mediator, and Fbw7 loss increases CDK8 module-Mediator association. Our work reveals a novel mechanism regulating CDK8 module-Mediator association and suggests an expanded role for Fbw7 in transcriptional control and an unanticipated relationship with the CDK8 oncogene.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: CDK8 — MED24 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — CDK8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — MED13 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CDK8 — MED23 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CDK8 — CDK8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED21 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED9 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED13L — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED13L — FBXW7 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: MED31 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED27 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED22 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED10 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED23 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED12 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED17 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FBXW7 — MED24 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED29 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — MED13L (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED8 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED20 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED4 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED15 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FBXW7 — MED19 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED16 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED13 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED13 — FBXW7 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: CCNC — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED30 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED14 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED6 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED28 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FBXW7 — MED11 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED13 — CDK8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — MED1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CUL1 — FBXW7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CDK8 — MED12 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — MED12 (physical association, affinity chromatography technology)
In total, 37 gene pairs are associated to this article in curated databases